Marine toxins targeting ion channels

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

This introductory minireview points out the importance of ion channels for cell communication. The basic concepts on the structure and function of ion channels triggered by membrane voltage changes, the so-called voltage-gated ion channels (VGICs), as well as those activated by neurotransmitters, the so-called ligand-gated ion channel (LGICs), are introduced. Among the most important VGIC superfamiles, we can name the voltage-gated Na + (NaV), Ca2 + (CaV), and K + (KV) channels. Among the most important LGIC super families, we can include the Cys-loop or nicotinicoid, the glutamate-activated (GluR), and the ATP-activated (P2X nR) receptor superfamilies. Ion channels are transmembrane proteins that allow the passage of different ions in a specific or unspecific manner. For instance, the activation of Na V, Ca V, or K V channels opens a pore that is specific for Na +, Ca2 +, or K +, respectively. On the other hand, the activation of certain LGICs such as nicotinic acetylcholine receptors, GluRs, and P2X nRs allows the passage of cations (e.g., Na +, K +, and/or Ca 2+), whereas the activation of other LGICs such as type A γ-butyric acid and glycine receptors allows the passage of anions (e.g., Cl - and/or HCO 3.). In this regard, the activation of Na V and Ca V as well as ligand-gated cation channels produce membrane depolarization, which finally leads to stimulatory effects in the cell, whereas the activation of K V as well as ligand-gated anion channels induce membrane hyperpolarization that finally leads to inhibitory effects in the cell. The importance of these ion channel superfamilies is emphasized by considering their physiological functions throughout the body as well as their pathophysiological implicance in several neuronal diseases. In this regard, natural molecules, and especially marine toxins, can be potentially used as modulators (e.g., inhibitors or prolongers) of ion channel functions to treat or to alleviate a specific ion channel-linked disease (e.g., channelopaties).

Original languageEnglish
Pages (from-to)31-69
Number of pages39
JournalMarine Drugs
Volume4
Issue number3
StatePublished - 1 Apr 2006
Externally publishedYes

Fingerprint

Marine Toxins
Ligand-Gated Ion Channels
Ion Channels
Anions
Membranes
Cations
Glycine Receptors
Butyric Acid
Nicotinic Receptors
Cell Communication
Names
Neurotransmitter Agents
Glutamic Acid
Adenosine Triphosphate
Ions

Keywords

  • Ligand-gated ion channels
  • Marine toxins
  • Natural toxins
  • Voltage-gated ion channels

Cite this

Arias, Hugo R. / Marine toxins targeting ion channels. In: Marine Drugs. 2006 ; Vol. 4, No. 3. pp. 31-69.
@article{b6ba691da15c4b60a252fe97513573ec,
title = "Marine toxins targeting ion channels",
abstract = "This introductory minireview points out the importance of ion channels for cell communication. The basic concepts on the structure and function of ion channels triggered by membrane voltage changes, the so-called voltage-gated ion channels (VGICs), as well as those activated by neurotransmitters, the so-called ligand-gated ion channel (LGICs), are introduced. Among the most important VGIC superfamiles, we can name the voltage-gated Na + (NaV), Ca2 + (CaV), and K + (KV) channels. Among the most important LGIC super families, we can include the Cys-loop or nicotinicoid, the glutamate-activated (GluR), and the ATP-activated (P2X nR) receptor superfamilies. Ion channels are transmembrane proteins that allow the passage of different ions in a specific or unspecific manner. For instance, the activation of Na V, Ca V, or K V channels opens a pore that is specific for Na +, Ca2 +, or K +, respectively. On the other hand, the activation of certain LGICs such as nicotinic acetylcholine receptors, GluRs, and P2X nRs allows the passage of cations (e.g., Na +, K +, and/or Ca 2+), whereas the activation of other LGICs such as type A γ-butyric acid and glycine receptors allows the passage of anions (e.g., Cl - and/or HCO 3.). In this regard, the activation of Na V and Ca V as well as ligand-gated cation channels produce membrane depolarization, which finally leads to stimulatory effects in the cell, whereas the activation of K V as well as ligand-gated anion channels induce membrane hyperpolarization that finally leads to inhibitory effects in the cell. The importance of these ion channel superfamilies is emphasized by considering their physiological functions throughout the body as well as their pathophysiological implicance in several neuronal diseases. In this regard, natural molecules, and especially marine toxins, can be potentially used as modulators (e.g., inhibitors or prolongers) of ion channel functions to treat or to alleviate a specific ion channel-linked disease (e.g., channelopaties).",
keywords = "Ligand-gated ion channels, Marine toxins, Natural toxins, Voltage-gated ion channels",
author = "Arias, {Hugo R.}",
year = "2006",
month = "4",
day = "1",
language = "English",
volume = "4",
pages = "31--69",
journal = "Marine Drugs",
issn = "1660-3397",
number = "3",

}

Arias, HR 2006, 'Marine toxins targeting ion channels', Marine Drugs, vol. 4, no. 3, pp. 31-69.

Marine toxins targeting ion channels. / Arias, Hugo R.

In: Marine Drugs, Vol. 4, No. 3, 01.04.2006, p. 31-69.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Marine toxins targeting ion channels

AU - Arias, Hugo R.

PY - 2006/4/1

Y1 - 2006/4/1

N2 - This introductory minireview points out the importance of ion channels for cell communication. The basic concepts on the structure and function of ion channels triggered by membrane voltage changes, the so-called voltage-gated ion channels (VGICs), as well as those activated by neurotransmitters, the so-called ligand-gated ion channel (LGICs), are introduced. Among the most important VGIC superfamiles, we can name the voltage-gated Na + (NaV), Ca2 + (CaV), and K + (KV) channels. Among the most important LGIC super families, we can include the Cys-loop or nicotinicoid, the glutamate-activated (GluR), and the ATP-activated (P2X nR) receptor superfamilies. Ion channels are transmembrane proteins that allow the passage of different ions in a specific or unspecific manner. For instance, the activation of Na V, Ca V, or K V channels opens a pore that is specific for Na +, Ca2 +, or K +, respectively. On the other hand, the activation of certain LGICs such as nicotinic acetylcholine receptors, GluRs, and P2X nRs allows the passage of cations (e.g., Na +, K +, and/or Ca 2+), whereas the activation of other LGICs such as type A γ-butyric acid and glycine receptors allows the passage of anions (e.g., Cl - and/or HCO 3.). In this regard, the activation of Na V and Ca V as well as ligand-gated cation channels produce membrane depolarization, which finally leads to stimulatory effects in the cell, whereas the activation of K V as well as ligand-gated anion channels induce membrane hyperpolarization that finally leads to inhibitory effects in the cell. The importance of these ion channel superfamilies is emphasized by considering their physiological functions throughout the body as well as their pathophysiological implicance in several neuronal diseases. In this regard, natural molecules, and especially marine toxins, can be potentially used as modulators (e.g., inhibitors or prolongers) of ion channel functions to treat or to alleviate a specific ion channel-linked disease (e.g., channelopaties).

AB - This introductory minireview points out the importance of ion channels for cell communication. The basic concepts on the structure and function of ion channels triggered by membrane voltage changes, the so-called voltage-gated ion channels (VGICs), as well as those activated by neurotransmitters, the so-called ligand-gated ion channel (LGICs), are introduced. Among the most important VGIC superfamiles, we can name the voltage-gated Na + (NaV), Ca2 + (CaV), and K + (KV) channels. Among the most important LGIC super families, we can include the Cys-loop or nicotinicoid, the glutamate-activated (GluR), and the ATP-activated (P2X nR) receptor superfamilies. Ion channels are transmembrane proteins that allow the passage of different ions in a specific or unspecific manner. For instance, the activation of Na V, Ca V, or K V channels opens a pore that is specific for Na +, Ca2 +, or K +, respectively. On the other hand, the activation of certain LGICs such as nicotinic acetylcholine receptors, GluRs, and P2X nRs allows the passage of cations (e.g., Na +, K +, and/or Ca 2+), whereas the activation of other LGICs such as type A γ-butyric acid and glycine receptors allows the passage of anions (e.g., Cl - and/or HCO 3.). In this regard, the activation of Na V and Ca V as well as ligand-gated cation channels produce membrane depolarization, which finally leads to stimulatory effects in the cell, whereas the activation of K V as well as ligand-gated anion channels induce membrane hyperpolarization that finally leads to inhibitory effects in the cell. The importance of these ion channel superfamilies is emphasized by considering their physiological functions throughout the body as well as their pathophysiological implicance in several neuronal diseases. In this regard, natural molecules, and especially marine toxins, can be potentially used as modulators (e.g., inhibitors or prolongers) of ion channel functions to treat or to alleviate a specific ion channel-linked disease (e.g., channelopaties).

KW - Ligand-gated ion channels

KW - Marine toxins

KW - Natural toxins

KW - Voltage-gated ion channels

UR - http://www.scopus.com/inward/record.url?scp=33646772912&partnerID=8YFLogxK

M3 - Review article

AN - SCOPUS:33646772912

VL - 4

SP - 31

EP - 69

JO - Marine Drugs

JF - Marine Drugs

SN - 1660-3397

IS - 3

ER -