Lithium chloride-induced anorexia, but not conditioned taste aversions, in rats with area postrema lesions

Kathleen Curtis, Alan F. Sved, Joseph G. Verbalis, Edward M. Stricker

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Area postrema (AP) lesions were produced by vacuum aspiration in adult male Sprague-Dawley rats. Consistent with previous findings, when water-deprived rats were allowed to drink novel flavored fluids immediately before treatment with LiCl (3 mEq/kg, i.p.), sham-operated and non-operated control rats demonstrated a pronounced aversion to the fluids whereas rats with AP lesions did not decrease fluid consumption significantly. However, in a 30-min test period after overnight food deprivation, rats with AP lesions reduced food intake significantly and to an equivalent degree as control animals when pretreated with LiCl (3 mEq/kg, i.p. or i.v.). These and other results are consistent with the traditional view that AP mediates the sensation of nausea produced by LiCl treatment (hence the loss of conditioned taste aversions after AP lesions), but suggest that neither nausea nor AP is necessary for the marked disinclination to eat that is induced in rats by acute administration of LiCl.

Original languageEnglish
Pages (from-to)30-37
Number of pages8
JournalBrain Research
Volume663
Issue number1
DOIs
StatePublished - 7 Nov 1994

Fingerprint

Area Postrema
Lithium Chloride
Anorexia
Nausea
Food Deprivation
Vacuum
Sprague Dawley Rats
Eating
Water
Therapeutics

Keywords

  • Hypothalamic paraventricular nucleus
  • Nausea
  • Oxytocin

Cite this

Curtis, Kathleen ; Sved, Alan F. ; Verbalis, Joseph G. ; Stricker, Edward M. / Lithium chloride-induced anorexia, but not conditioned taste aversions, in rats with area postrema lesions. In: Brain Research. 1994 ; Vol. 663, No. 1. pp. 30-37.
@article{2a0aa22a3d9946cfbbc3ac9a62f30d8d,
title = "Lithium chloride-induced anorexia, but not conditioned taste aversions, in rats with area postrema lesions",
abstract = "Area postrema (AP) lesions were produced by vacuum aspiration in adult male Sprague-Dawley rats. Consistent with previous findings, when water-deprived rats were allowed to drink novel flavored fluids immediately before treatment with LiCl (3 mEq/kg, i.p.), sham-operated and non-operated control rats demonstrated a pronounced aversion to the fluids whereas rats with AP lesions did not decrease fluid consumption significantly. However, in a 30-min test period after overnight food deprivation, rats with AP lesions reduced food intake significantly and to an equivalent degree as control animals when pretreated with LiCl (3 mEq/kg, i.p. or i.v.). These and other results are consistent with the traditional view that AP mediates the sensation of nausea produced by LiCl treatment (hence the loss of conditioned taste aversions after AP lesions), but suggest that neither nausea nor AP is necessary for the marked disinclination to eat that is induced in rats by acute administration of LiCl.",
keywords = "Hypothalamic paraventricular nucleus, Nausea, Oxytocin",
author = "Kathleen Curtis and Sved, {Alan F.} and Verbalis, {Joseph G.} and Stricker, {Edward M.}",
year = "1994",
month = "11",
day = "7",
doi = "10.1016/0006-8993(94)90459-6",
language = "English",
volume = "663",
pages = "30--37",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",

}

Lithium chloride-induced anorexia, but not conditioned taste aversions, in rats with area postrema lesions. / Curtis, Kathleen; Sved, Alan F.; Verbalis, Joseph G.; Stricker, Edward M.

In: Brain Research, Vol. 663, No. 1, 07.11.1994, p. 30-37.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Lithium chloride-induced anorexia, but not conditioned taste aversions, in rats with area postrema lesions

AU - Curtis, Kathleen

AU - Sved, Alan F.

AU - Verbalis, Joseph G.

AU - Stricker, Edward M.

PY - 1994/11/7

Y1 - 1994/11/7

N2 - Area postrema (AP) lesions were produced by vacuum aspiration in adult male Sprague-Dawley rats. Consistent with previous findings, when water-deprived rats were allowed to drink novel flavored fluids immediately before treatment with LiCl (3 mEq/kg, i.p.), sham-operated and non-operated control rats demonstrated a pronounced aversion to the fluids whereas rats with AP lesions did not decrease fluid consumption significantly. However, in a 30-min test period after overnight food deprivation, rats with AP lesions reduced food intake significantly and to an equivalent degree as control animals when pretreated with LiCl (3 mEq/kg, i.p. or i.v.). These and other results are consistent with the traditional view that AP mediates the sensation of nausea produced by LiCl treatment (hence the loss of conditioned taste aversions after AP lesions), but suggest that neither nausea nor AP is necessary for the marked disinclination to eat that is induced in rats by acute administration of LiCl.

AB - Area postrema (AP) lesions were produced by vacuum aspiration in adult male Sprague-Dawley rats. Consistent with previous findings, when water-deprived rats were allowed to drink novel flavored fluids immediately before treatment with LiCl (3 mEq/kg, i.p.), sham-operated and non-operated control rats demonstrated a pronounced aversion to the fluids whereas rats with AP lesions did not decrease fluid consumption significantly. However, in a 30-min test period after overnight food deprivation, rats with AP lesions reduced food intake significantly and to an equivalent degree as control animals when pretreated with LiCl (3 mEq/kg, i.p. or i.v.). These and other results are consistent with the traditional view that AP mediates the sensation of nausea produced by LiCl treatment (hence the loss of conditioned taste aversions after AP lesions), but suggest that neither nausea nor AP is necessary for the marked disinclination to eat that is induced in rats by acute administration of LiCl.

KW - Hypothalamic paraventricular nucleus

KW - Nausea

KW - Oxytocin

UR - http://www.scopus.com/inward/record.url?scp=0028091907&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(94)90459-6

DO - 10.1016/0006-8993(94)90459-6

M3 - Article

C2 - 7850468

AN - SCOPUS:0028091907

VL - 663

SP - 30

EP - 37

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -