Limbic networks and associative learning: II. Entorhinal contributions to spontaneous alternation, passive avoidance, and taste aversion learning

Kevin S. Seybold, Kathleen Curtis, Patricia W. Parsons, Chikako Inoue, Richard L. Port

Research output: Contribution to journalArticle

Abstract

The hippocampus plays an important role in learning and memory, but the precise nature of that involvement remains uncertain. Transection of the perforant path, a primary input pathway to the hippocampus, has been shown to produce changes in reaction to novelty and acquisition of active avoidance; the nature and magnitude of these changes vary with lateral or medial perforant path damage. In a series of experiments on adult rats, the role of these pathways in spontaneous alternation, exploration, acquisition and extinction of conditioned responses, passive avoidance, and conditioned taste aversion was investigated. Lateral transection reduced exploration while medial transection facilitated acquisition of an active avoidance response; no effects were observed on any other measure. Results are discussed in terms of what perforant path damage might reveal regarding the interactions of the hippocampus with other brain regions.

Original languageEnglish
Pages (from-to)283-295
Number of pages13
JournalCurrent Psychology
Volume12
Issue number4
DOIs
StatePublished - 1 Dec 1993

Fingerprint

Perforant Pathway
Hippocampus
Learning
Brain

Cite this

Seybold, Kevin S. ; Curtis, Kathleen ; Parsons, Patricia W. ; Inoue, Chikako ; Port, Richard L. / Limbic networks and associative learning : II. Entorhinal contributions to spontaneous alternation, passive avoidance, and taste aversion learning. In: Current Psychology. 1993 ; Vol. 12, No. 4. pp. 283-295.
@article{9efa6b247b7e46c9af767c0468e3f874,
title = "Limbic networks and associative learning: II. Entorhinal contributions to spontaneous alternation, passive avoidance, and taste aversion learning",
abstract = "The hippocampus plays an important role in learning and memory, but the precise nature of that involvement remains uncertain. Transection of the perforant path, a primary input pathway to the hippocampus, has been shown to produce changes in reaction to novelty and acquisition of active avoidance; the nature and magnitude of these changes vary with lateral or medial perforant path damage. In a series of experiments on adult rats, the role of these pathways in spontaneous alternation, exploration, acquisition and extinction of conditioned responses, passive avoidance, and conditioned taste aversion was investigated. Lateral transection reduced exploration while medial transection facilitated acquisition of an active avoidance response; no effects were observed on any other measure. Results are discussed in terms of what perforant path damage might reveal regarding the interactions of the hippocampus with other brain regions.",
author = "Seybold, {Kevin S.} and Kathleen Curtis and Parsons, {Patricia W.} and Chikako Inoue and Port, {Richard L.}",
year = "1993",
month = "12",
day = "1",
doi = "10.1007/BF02686810",
language = "English",
volume = "12",
pages = "283--295",
journal = "Current Psychology",
issn = "0737-8262",
publisher = "Springer New York",
number = "4",

}

Limbic networks and associative learning : II. Entorhinal contributions to spontaneous alternation, passive avoidance, and taste aversion learning. / Seybold, Kevin S.; Curtis, Kathleen; Parsons, Patricia W.; Inoue, Chikako; Port, Richard L.

In: Current Psychology, Vol. 12, No. 4, 01.12.1993, p. 283-295.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Limbic networks and associative learning

T2 - II. Entorhinal contributions to spontaneous alternation, passive avoidance, and taste aversion learning

AU - Seybold, Kevin S.

AU - Curtis, Kathleen

AU - Parsons, Patricia W.

AU - Inoue, Chikako

AU - Port, Richard L.

PY - 1993/12/1

Y1 - 1993/12/1

N2 - The hippocampus plays an important role in learning and memory, but the precise nature of that involvement remains uncertain. Transection of the perforant path, a primary input pathway to the hippocampus, has been shown to produce changes in reaction to novelty and acquisition of active avoidance; the nature and magnitude of these changes vary with lateral or medial perforant path damage. In a series of experiments on adult rats, the role of these pathways in spontaneous alternation, exploration, acquisition and extinction of conditioned responses, passive avoidance, and conditioned taste aversion was investigated. Lateral transection reduced exploration while medial transection facilitated acquisition of an active avoidance response; no effects were observed on any other measure. Results are discussed in terms of what perforant path damage might reveal regarding the interactions of the hippocampus with other brain regions.

AB - The hippocampus plays an important role in learning and memory, but the precise nature of that involvement remains uncertain. Transection of the perforant path, a primary input pathway to the hippocampus, has been shown to produce changes in reaction to novelty and acquisition of active avoidance; the nature and magnitude of these changes vary with lateral or medial perforant path damage. In a series of experiments on adult rats, the role of these pathways in spontaneous alternation, exploration, acquisition and extinction of conditioned responses, passive avoidance, and conditioned taste aversion was investigated. Lateral transection reduced exploration while medial transection facilitated acquisition of an active avoidance response; no effects were observed on any other measure. Results are discussed in terms of what perforant path damage might reveal regarding the interactions of the hippocampus with other brain regions.

UR - http://www.scopus.com/inward/record.url?scp=51649136610&partnerID=8YFLogxK

U2 - 10.1007/BF02686810

DO - 10.1007/BF02686810

M3 - Article

AN - SCOPUS:51649136610

VL - 12

SP - 283

EP - 295

JO - Current Psychology

JF - Current Psychology

SN - 0737-8262

IS - 4

ER -