KCNQ2 and KCNQ3 potassium channel subunits: Molecular correlates of the M-channel

Hong Sheng Wang, Zongming Pan, Wenmei Shi, Barry S. Brown, Randy S. Wymore, Ira S. Cohen, Jane E. Dixon, David McKinnon

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Abstract

The M-current regulates the subthreshold electrical excitability of many neurons, determining their firing properties and responsiveness to synaptic input. To date, however, the genes that encode subunits of this important channel have not been identified. The biophysical properties, sensitivity to pharmacological blockade, and expression pattern of the KCNQ2 and KCNQ3 potassium channels were determined. It is concluded that both these subunits contribute to the native M-current.

Original languageEnglish
Pages (from-to)1890-1893
Number of pages4
JournalScience
Volume282
Issue number5395
DOIs
StatePublished - 4 Dec 1998

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Wang, H. S., Pan, Z., Shi, W., Brown, B. S., Wymore, R. S., Cohen, I. S., Dixon, J. E., & McKinnon, D. (1998). KCNQ2 and KCNQ3 potassium channel subunits: Molecular correlates of the M-channel. Science, 282(5395), 1890-1893. https://doi.org/10.1126/science.282.5395.1890