KCNQ2 and KCNQ3 potassium channel subunits: Molecular correlates of the M-channel

Hong Sheng Wang; Zongming Pan; Wenmei Shi; Barry S. Brown; Randy S. Wymore; Ira S. Cohen; Jane E. Dixon; David McKinnon

doi:10.1126/science.282.5395.1890

KCNQ2 and KCNQ3 potassium channel subunits: Molecular correlates of the M-channel

Hong Sheng Wang, Zongming Pan, Wenmei Shi, Barry S. Brown, Randy S. Wymore, Ira S. Cohen, Jane E. Dixon, David McKinnon

Pharmacology and Physiology

Research output: Contribution to journal › Article › peer-review

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Abstract

The M-current regulates the subthreshold electrical excitability of many neurons, determining their firing properties and responsiveness to synaptic input. To date, however, the genes that encode subunits of this important channel have not been identified. The biophysical properties, sensitivity to pharmacological blockade, and expression pattern of the KCNQ2 and KCNQ3 potassium channels were determined. It is concluded that both these subunits contribute to the native M-current.

Original language	English
Pages (from-to)	1890-1893
Number of pages	4
Journal	Science
Volume	282
Issue number	5395
DOIs	https://doi.org/10.1126/science.282.5395.1890
State	Published - 4 Dec 1998

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abstract = "The M-current regulates the subthreshold electrical excitability of many neurons, determining their firing properties and responsiveness to synaptic input. To date, however, the genes that encode subunits of this important channel have not been identified. The biophysical properties, sensitivity to pharmacological blockade, and expression pattern of the KCNQ2 and KCNQ3 potassium channels were determined. It is concluded that both these subunits contribute to the native M-current.",

author = "Wang, {Hong Sheng} and Zongming Pan and Wenmei Shi and Brown, {Barry S.} and Wymore, {Randy S.} and Cohen, {Ira S.} and Dixon, {Jane E.} and David McKinnon",

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AU - Wang, Hong Sheng

AU - Pan, Zongming

AU - Shi, Wenmei

AU - Brown, Barry S.

AU - Wymore, Randy S.

AU - Cohen, Ira S.

AU - Dixon, Jane E.

AU - McKinnon, David

PY - 1998/12/4

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AB - The M-current regulates the subthreshold electrical excitability of many neurons, determining their firing properties and responsiveness to synaptic input. To date, however, the genes that encode subunits of this important channel have not been identified. The biophysical properties, sensitivity to pharmacological blockade, and expression pattern of the KCNQ2 and KCNQ3 potassium channels were determined. It is concluded that both these subunits contribute to the native M-current.

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KCNQ2 and KCNQ3 potassium channel subunits: Molecular correlates of the M-channel

Abstract

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