Isolation of cytomegalovirus and foamy virus from the drill monkey (Mandrillus leucophaeus) and prevalence of antibodies to these viruses amongst wild-born and captive-bred individuals

E. L. Blewett, J. Lewis, E. L. Gadsby, S. R. Neubauer, R. Eberle

Research output: Contribution to journalShort survey

18 Citations (Scopus)

Abstract

Drill monkeys (Mandrillus leucophaeus) are an endangered species whose indigenous viral flora is largely unknown. We report here the isolation and characterization of both a cytomegalovirus (DrCMV) and a foamy virus (SFV-dr1) from drill monkeys. Phylogenetic analysis of DNA sequence data placed the DrCMV within a primate CMV clade, and showed that SFV-dr1 was closely related to baboon foamy viruses. ELISA analysis demonstrated that DrCMV shared common epitopes with other primate CMVs but was distinct from human and baboon CMVs. ELISA testing of sera from wild-born and captive-bred drills indicated that the prevalence of antibodies reactive with these two viruses was 93.2% for DrCMV and 20.3% for SFV-dr1.

Original languageEnglish
Pages (from-to)423-433
Number of pages11
JournalArchives of Virology
Volume148
Issue number3
DOIs
StatePublished - 1 Mar 2003

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Spumavirus
Mandrillus
Cytomegalovirus
Haplorhini
Viruses
Antibodies
Papio
Primates
Enzyme-Linked Immunosorbent Assay
Endangered Species
DNA Sequence Analysis
Epitopes
Serum

Cite this

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title = "Isolation of cytomegalovirus and foamy virus from the drill monkey (Mandrillus leucophaeus) and prevalence of antibodies to these viruses amongst wild-born and captive-bred individuals",
abstract = "Drill monkeys (Mandrillus leucophaeus) are an endangered species whose indigenous viral flora is largely unknown. We report here the isolation and characterization of both a cytomegalovirus (DrCMV) and a foamy virus (SFV-dr1) from drill monkeys. Phylogenetic analysis of DNA sequence data placed the DrCMV within a primate CMV clade, and showed that SFV-dr1 was closely related to baboon foamy viruses. ELISA analysis demonstrated that DrCMV shared common epitopes with other primate CMVs but was distinct from human and baboon CMVs. ELISA testing of sera from wild-born and captive-bred drills indicated that the prevalence of antibodies reactive with these two viruses was 93.2{\%} for DrCMV and 20.3{\%} for SFV-dr1.",
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Isolation of cytomegalovirus and foamy virus from the drill monkey (Mandrillus leucophaeus) and prevalence of antibodies to these viruses amongst wild-born and captive-bred individuals. / Blewett, E. L.; Lewis, J.; Gadsby, E. L.; Neubauer, S. R.; Eberle, R.

In: Archives of Virology, Vol. 148, No. 3, 01.03.2003, p. 423-433.

Research output: Contribution to journalShort survey

TY - JOUR

T1 - Isolation of cytomegalovirus and foamy virus from the drill monkey (Mandrillus leucophaeus) and prevalence of antibodies to these viruses amongst wild-born and captive-bred individuals

AU - Blewett, E. L.

AU - Lewis, J.

AU - Gadsby, E. L.

AU - Neubauer, S. R.

AU - Eberle, R.

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AB - Drill monkeys (Mandrillus leucophaeus) are an endangered species whose indigenous viral flora is largely unknown. We report here the isolation and characterization of both a cytomegalovirus (DrCMV) and a foamy virus (SFV-dr1) from drill monkeys. Phylogenetic analysis of DNA sequence data placed the DrCMV within a primate CMV clade, and showed that SFV-dr1 was closely related to baboon foamy viruses. ELISA analysis demonstrated that DrCMV shared common epitopes with other primate CMVs but was distinct from human and baboon CMVs. ELISA testing of sera from wild-born and captive-bred drills indicated that the prevalence of antibodies reactive with these two viruses was 93.2% for DrCMV and 20.3% for SFV-dr1.

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