Investigating Recruitment and Retention Strategies in Clinical Trials of Historically Marginalized Patients with Major Depressive Disorder: A Cross-Sectional Analysis

Research output: Contribution to conferencePosterpeer-review

Abstract

Purpose: The purpose of this study was to examine recruitment and retention strategies put forth by researchers and determine whether there are socioeconomic obstacles and identify solutions to expand inclusion strategies.

Design Methods: This cross-sectional analysis examined recruitment and retention strategies for disinvested populations in clinical trials focused on MDD, following PRISMA guidelines. We screened MEDLINE (PubMed) and Embase (Elsevier) for trials from January 1, 2021, to December 31, 2023.. Eligible US-based trials underwent data extraction. Statistical analyses were completed with Stata18 SE.

Results: Of the 2,051 records identified, 49 articles were ultimately included for data extraction. Recruitment strategies were notably absent in 91.8% of studies, with 89.8% of the studies lacking a planned diversity goal. Retention strategies were also lacking in 85.7% of studies. Among the challenges noted, 26.5% of studies discussed limitations related to recruitment and population diversity.

Discussion: Our study identified significant deficiencies in MDD clinical trial strategies for recruiting and retaining historically marginalized groups in the United States, revealing that less than 10% of studies included diversity goals and less than 5% addressed ethical considerations for diverse participant recruitment. These findings compromise the validity and applicability of research outcomes and exacerbates health inequities. To address these gaps, future research should focus on implementing novel recruitment methodologies and policy reforms to enhance inclusivity and improve healthcare decision-making for diverse populations affected by MDD.
Original languageAmerican English
Pages63
StatePublished - 13 Sep 2024
Event2024 Symposium on Tribal and Rural Innovations in Disparities and Equity for Health - Oklahoma State University College of Osteopathic Medicine at the Cherokee Nation, Tahlequah, United States
Duration: 13 Sep 202413 Sep 2024

Conference

Conference2024 Symposium on Tribal and Rural Innovations in Disparities and Equity for Health
Abbreviated titleSTRIDE 2024
Country/TerritoryUnited States
CityTahlequah
Period13/09/2413/09/24

Fingerprint

Dive into the research topics of 'Investigating Recruitment and Retention Strategies in Clinical Trials of Historically Marginalized Patients with Major Depressive Disorder: A Cross-Sectional Analysis'. Together they form a unique fingerprint.

Cite this