Abstract
Purpose: This study aims to investigate recruitment and retention strategies in Atopic Dermatitis (AD) clinical trials.
Design Methods: We conducted a cross-sectional analysis following PRISMA guidelines to assess recruitment and retention strategies in AD clinical trials. The relevant clinical trials were acquired in a comprehensive search of MEDLINE (PubMed) and Embase (Elsevier) on May 28, 2024. Data were extracted from trials published between January 1, 2013 and December 31, 2023. For statistical analysis, Stata 18 SE (StataCorpStataCorp LLC, College Station, TX) was used to determine the frequencies of recruitment and retention strategies.
Results: Of the 32 trials analyzed, only 4/32 (12.5%) integrated recruitment strategies to include underrepresented populations and only 4/32 (12.5%) had planned diversity goals to improve recruitment. Three out of the 32 (9.4%) studies reported challenges with recruitment.
Conclusion: Our study highlights the need for inclusive recruitment and retention strategies in AD clinical trials. The lack of diverse representation in clinical trials can contribute to obstacles in medical research and can eventually prevent advancements in treatment outcomes. It is essential to address these gaps to ensure the external validity of research findings and to improve treatment outcomes.
Design Methods: We conducted a cross-sectional analysis following PRISMA guidelines to assess recruitment and retention strategies in AD clinical trials. The relevant clinical trials were acquired in a comprehensive search of MEDLINE (PubMed) and Embase (Elsevier) on May 28, 2024. Data were extracted from trials published between January 1, 2013 and December 31, 2023. For statistical analysis, Stata 18 SE (StataCorpStataCorp LLC, College Station, TX) was used to determine the frequencies of recruitment and retention strategies.
Results: Of the 32 trials analyzed, only 4/32 (12.5%) integrated recruitment strategies to include underrepresented populations and only 4/32 (12.5%) had planned diversity goals to improve recruitment. Three out of the 32 (9.4%) studies reported challenges with recruitment.
Conclusion: Our study highlights the need for inclusive recruitment and retention strategies in AD clinical trials. The lack of diverse representation in clinical trials can contribute to obstacles in medical research and can eventually prevent advancements in treatment outcomes. It is essential to address these gaps to ensure the external validity of research findings and to improve treatment outcomes.
Original language | American English |
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Pages | 46 |
State | Published - 13 Sep 2024 |
Event | 2024 Symposium on Tribal and Rural Innovations in Disparities and Equity for Health - Oklahoma State University College of Osteopathic Medicine at the Cherokee Nation, Tahlequah, United States Duration: 13 Sep 2024 → 13 Sep 2024 |
Conference
Conference | 2024 Symposium on Tribal and Rural Innovations in Disparities and Equity for Health |
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Abbreviated title | STRIDE 2024 |
Country/Territory | United States |
City | Tahlequah |
Period | 13/09/24 → 13/09/24 |