Intrathecal dynorphins suppress hindlimb electromyographic activity in rats

Craig W. Stevens; Matthew B. Weinger; Tony L. Yaksh

doi:10.1016/0014-2999(87)90449-3

Intrathecal dynorphins suppress hindlimb electromyographic activity in rats

Craig W. Stevens, Matthew B. Weinger, Tony L. Yaksh

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Intrathecal administration of dynorphin A-(1-17) produced suppression of hindlimb electromyographic activity in rats. This effect was seen also with the [D-Ala²]dynorphin (A-(1-17) analog. Intrathecal saline or the prototypical κ opiate agonist, U50488, did not produce any change in electromyographic activity. These results, along with others, suggest that dynorphin or degradation fragment(s) of dynorphin, induces inhibition of ventral horn output and may possibly have toxic effects on ventral horn cells of the spinal cord.

Original language	English
Pages (from-to)	299-302
Number of pages	4
Journal	European Journal of Pharmacology
Volume	138
Issue number	2
DOIs	https://doi.org/10.1016/0014-2999(87)90449-3
State	Published - 19 Jun 1987

Keywords

(Intrathecal administration)
Dynorphin A-(1-17)
Motor dysfunction
U50488
κ Opiates

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10.1016/0014-2999(87)90449-3

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title = "Intrathecal dynorphins suppress hindlimb electromyographic activity in rats",

abstract = "Intrathecal administration of dynorphin A-(1-17) produced suppression of hindlimb electromyographic activity in rats. This effect was seen also with the [D-Ala2]dynorphin (A-(1-17) analog. Intrathecal saline or the prototypical κ opiate agonist, U50488, did not produce any change in electromyographic activity. These results, along with others, suggest that dynorphin or degradation fragment(s) of dynorphin, induces inhibition of ventral horn output and may possibly have toxic effects on ventral horn cells of the spinal cord.",

keywords = "(Intrathecal administration), Dynorphin A-(1-17), Motor dysfunction, U50488, κ Opiates",

author = "Stevens, {Craig W.} and Weinger, {Matthew B.} and Yaksh, {Tony L.}",

note = "Funding Information: The authors thank Ms. Ann RockafeUow for manuscript preparanon and Ms. Vivmn Mancini for careful proofreading. This work was supported by NIH Grant DA-02110 and the Mayo Foundation.",

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T1 - Intrathecal dynorphins suppress hindlimb electromyographic activity in rats

AU - Stevens, Craig W.

AU - Weinger, Matthew B.

AU - Yaksh, Tony L.

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PY - 1987/6/19

Y1 - 1987/6/19

N2 - Intrathecal administration of dynorphin A-(1-17) produced suppression of hindlimb electromyographic activity in rats. This effect was seen also with the [D-Ala2]dynorphin (A-(1-17) analog. Intrathecal saline or the prototypical κ opiate agonist, U50488, did not produce any change in electromyographic activity. These results, along with others, suggest that dynorphin or degradation fragment(s) of dynorphin, induces inhibition of ventral horn output and may possibly have toxic effects on ventral horn cells of the spinal cord.

AB - Intrathecal administration of dynorphin A-(1-17) produced suppression of hindlimb electromyographic activity in rats. This effect was seen also with the [D-Ala2]dynorphin (A-(1-17) analog. Intrathecal saline or the prototypical κ opiate agonist, U50488, did not produce any change in electromyographic activity. These results, along with others, suggest that dynorphin or degradation fragment(s) of dynorphin, induces inhibition of ventral horn output and may possibly have toxic effects on ventral horn cells of the spinal cord.

KW - (Intrathecal administration)

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KW - Motor dysfunction

KW - U50488

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Intrathecal dynorphins suppress hindlimb electromyographic activity in rats

Abstract

Keywords

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