Intrathecal dynorphins suppress hindlimb electromyographic activity in rats

Craig W. Stevens, Matthew B. Weinger, Tony L. Yaksh

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Intrathecal administration of dynorphin A-(1-17) produced suppression of hindlimb electromyographic activity in rats. This effect was seen also with the [D-Ala2]dynorphin (A-(1-17) analog. Intrathecal saline or the prototypical κ opiate agonist, U50488, did not produce any change in electromyographic activity. These results, along with others, suggest that dynorphin or degradation fragment(s) of dynorphin, induces inhibition of ventral horn output and may possibly have toxic effects on ventral horn cells of the spinal cord.

Original languageEnglish
Pages (from-to)299-302
Number of pages4
JournalEuropean Journal of Pharmacology
Volume138
Issue number2
DOIs
StatePublished - 19 Jun 1987

Keywords

  • (Intrathecal administration)
  • Dynorphin A-(1-17)
  • Motor dysfunction
  • U50488
  • κ Opiates

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