Intestinal microbiome and metal toxicity

Senait Assefa, Gerwald Köhler

Research output: Contribution to journalReview article

Abstract

The human gut microbiome is considered critical for establishing and maintaining intestinal function and homeostasis throughout life. Evidence for bidirectional communication with the immune and nervous systems has spawned interest in the microbiome as a key factor for human and animal health. Consequently, appreciation of the microbiome as a target of xenobiotics, including environmental pollutants such as heavy metals, has risen steadily because disruption of a healthy microbiome (dysbiosis) has been linked to unfavorable health outcomes. Thus, toxicology must consider toxicant effects on the host's microbiome as an integral part of the holobiont. We discuss current findings on the impact of toxic metals on the composition, diversity, and function of the gut microbiome as well as the modulation of metal toxicity by the microbiome. Present limitations and future needs in elucidating microbiome-metal interactions and the potential of harnessing beneficial traits of the microbiota to counteract metal toxicity are also considered.

Original languageEnglish
Pages (from-to)21-27
Number of pages7
JournalCurrent Opinion in Toxicology
Volume19
DOIs
StatePublished - Feb 2020

Fingerprint

Microbiota
Toxicity
Metals
Health
Environmental Pollutants
Immune system
Poisons
Neurology
Xenobiotics
Heavy Metals
Animals
Dysbiosis
Modulation
Gastrointestinal Microbiome
Communication
Chemical analysis
Toxicology
Nervous System
Immune System
Homeostasis

Keywords

  • Arsenic
  • Cadmium
  • Lead
  • Mercury
  • Microbiome
  • Microbiota

Cite this

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abstract = "The human gut microbiome is considered critical for establishing and maintaining intestinal function and homeostasis throughout life. Evidence for bidirectional communication with the immune and nervous systems has spawned interest in the microbiome as a key factor for human and animal health. Consequently, appreciation of the microbiome as a target of xenobiotics, including environmental pollutants such as heavy metals, has risen steadily because disruption of a healthy microbiome (dysbiosis) has been linked to unfavorable health outcomes. Thus, toxicology must consider toxicant effects on the host's microbiome as an integral part of the holobiont. We discuss current findings on the impact of toxic metals on the composition, diversity, and function of the gut microbiome as well as the modulation of metal toxicity by the microbiome. Present limitations and future needs in elucidating microbiome-metal interactions and the potential of harnessing beneficial traits of the microbiota to counteract metal toxicity are also considered.",
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Intestinal microbiome and metal toxicity. / Assefa, Senait; Köhler, Gerwald.

In: Current Opinion in Toxicology, Vol. 19, 02.2020, p. 21-27.

Research output: Contribution to journalReview article

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T1 - Intestinal microbiome and metal toxicity

AU - Assefa, Senait

AU - Köhler, Gerwald

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