Intestinal Microbiome and Metal Toxicity

Senait Assefa, Gerwald Köhler

Research output: Contribution to journalArticle

Abstract

The human gut microbiome is considered critical for establishing and maintaining intestinal function and homeostasis throughout life. Evidence for bidirectional communication with the immune and nervous systems has spawned interest in the microbiome as a key factor for human and animal health. Consequently, appreciation of the microbiome as a target of xenobiotics, including environmental pollutants such as heavy metals, has risen steadily because disruption of a healthy microbiome (dysbiosis) has been linked to unfavorable health outcomes. Thus, toxicology must consider toxicant effects on the host’s microbiome as an integral part of the holobiont. We discuss current findings on the impact of toxic metals on the composition, diversity, and function of the gut microbiome as well as the modulation of metal toxicity by the microbiome. Present limitations and future needs in elucidating microbiome-metal interactions and the potential of harnessing beneficial traits of the microbiota to counteract metal toxicity are also considered.
Original languageAmerican English
JournalCurrent Opinion in Toxicology
DOIs
StatePublished - 30 Sep 2019

Fingerprint

Microbiota
Metals
Dysbiosis
Environmental Pollutants
Gastrointestinal Microbiome
Poisons
Health
Xenobiotics
Heavy Metals
Toxicology
Nervous System
Immune System
Homeostasis
Communication

Keywords

  • Gut microbiome
  • microbiota
  • dysbiosis
  • heavy metal
  • toxicity
  • 16S rRNA
  • metagenomics
  • arsenic
  • cadmium
  • chromium
  • mercury
  • lead

Cite this

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abstract = "The human gut microbiome is considered critical for establishing and maintaining intestinal function and homeostasis throughout life. Evidence for bidirectional communication with the immune and nervous systems has spawned interest in the microbiome as a key factor for human and animal health. Consequently, appreciation of the microbiome as a target of xenobiotics, including environmental pollutants such as heavy metals, has risen steadily because disruption of a healthy microbiome (dysbiosis) has been linked to unfavorable health outcomes. Thus, toxicology must consider toxicant effects on the host’s microbiome as an integral part of the holobiont. We discuss current findings on the impact of toxic metals on the composition, diversity, and function of the gut microbiome as well as the modulation of metal toxicity by the microbiome. Present limitations and future needs in elucidating microbiome-metal interactions and the potential of harnessing beneficial traits of the microbiota to counteract metal toxicity are also considered.",
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Intestinal Microbiome and Metal Toxicity. / Assefa, Senait; Köhler, Gerwald.

In: Current Opinion in Toxicology, 30.09.2019.

Research output: Contribution to journalArticle

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