Interaction of midazolam and morphine in the spinal cord of the rat

A. Yanez, M. B. Sabbe, Craig Stevens, T. L. Yaksh

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

The antinociceptive properties, as measured by the tail-flick and hot-plate tests, and the motor effects of an intrathecally-administered benzodiazepine agonist midazolam, alone, and in combination with morphine, was examined in rats. Midazolam alone produced a weak but dose-dependent (20-60 μg) antinociceptive effect in addition to a clear motor dysfunction at larger doses (60-100 μg). An inactive dose of intrathecally-administered midazolam (20 μg) produced a leftward shift in the dose-response curve for intrathecally administered morphine, in the thermal antinociceptive tests. This supra-additive effect was antagonized by naloxone (1 mg/kg). The data suggest a synergistic interaction between μ- and GABAA-receptors in the spinal processing of thermally-evoked pain.

Original languageEnglish
Pages (from-to)359-364
Number of pages6
JournalNeuropharmacology
Volume29
Issue number4
DOIs
StatePublished - 1 Jan 1990

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Midazolam
Morphine
Spinal Cord
GABA-A Receptors
Naloxone
Benzodiazepines
Tail
Hot Temperature
Pain

Keywords

  • GABA receptor
  • midazolam
  • morphine
  • spinal analgesia

Cite this

Yanez, A. ; Sabbe, M. B. ; Stevens, Craig ; Yaksh, T. L. / Interaction of midazolam and morphine in the spinal cord of the rat. In: Neuropharmacology. 1990 ; Vol. 29, No. 4. pp. 359-364.
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Interaction of midazolam and morphine in the spinal cord of the rat. / Yanez, A.; Sabbe, M. B.; Stevens, Craig; Yaksh, T. L.

In: Neuropharmacology, Vol. 29, No. 4, 01.01.1990, p. 359-364.

Research output: Contribution to journalArticle

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