Influence of altitude and caffeine during rest and exercise on plasma levels of proenkephalin Peptide F

William J. Kraemer, Paul Rock, Charles S. Fulco, Scott E. Gordon, Jeff P. Bonner, Charles D. Cruthirds, Louis J. Marchitelli, Laurie Trad, Allen Cymerman

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The purpose of this study was to examine the resting and exercise response patterns of plasma Peptide F immunoreactivity (ir) to altitude exposure (4300 m) and caffeine ingestion (4 mg·kg b.w.-1). Nine healthy male subjects performed exercise tests to exhaustion (80-85% VO2max) at sea level (50 m), during an acute altitude exposure (1 hr, hypobaric chamber, 4300 m) and after a chronic (17-day sojourn, 4300 m) altitude exposure. Using a randomized, double-blind/placebo experimental design, a placebo or caffeine drink was ingested 1 hour prior to exercise. Exercise (without caffeine) significantly (p<0.05) increased plasma Peptide F ir values during exercise at chronic altitude only. Caffeine ingestion significantly increased plasma Peptide F ir concentrations during exercise and in the postexercise period at sea level. Conversely caffeine ingestion at altitude resulted in significant reductions in the postexercise plasma Peptide F ir values. The results of this study demonstrate that the exercise and recovery response patterns of plasma Peptide F ir may be significantly altered by altitude exposure and caffeine ingestion. These data support further study examining relationships between Peptide F (and other enkephalin-containing polypeptides) and epinephrine release in response to these types of physiological stresses.

Original languageEnglish
Pages (from-to)1115-1119
Number of pages5
JournalPeptides
Volume9
Issue number5
DOIs
StatePublished - 1 Jan 1988

Keywords

  • Altitude acclimatization
  • Caffeine
  • Cardiovascular
  • Endogenous opioid peptides
  • Endurance exercise
  • Lactate

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    Kraemer, W. J., Rock, P., Fulco, C. S., Gordon, S. E., Bonner, J. P., Cruthirds, C. D., Marchitelli, L. J., Trad, L., & Cymerman, A. (1988). Influence of altitude and caffeine during rest and exercise on plasma levels of proenkephalin Peptide F. Peptides, 9(5), 1115-1119. https://doi.org/10.1016/0196-9781(88)90098-8