Influence of altitude and caffeine during rest and exercise on plasma levels of proenkephalin Peptide F

William J. Kraemer, Paul Rock, Charles S. Fulco, Scott E. Gordon, Jeff P. Bonner, Charles D. Cruthirds, Louis J. Marchitelli, Laurie Trad, Allen Cymerman

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The purpose of this study was to examine the resting and exercise response patterns of plasma Peptide F immunoreactivity (ir) to altitude exposure (4300 m) and caffeine ingestion (4 mg·kg b.w.-1). Nine healthy male subjects performed exercise tests to exhaustion (80-85% VO2max) at sea level (50 m), during an acute altitude exposure (1 hr, hypobaric chamber, 4300 m) and after a chronic (17-day sojourn, 4300 m) altitude exposure. Using a randomized, double-blind/placebo experimental design, a placebo or caffeine drink was ingested 1 hour prior to exercise. Exercise (without caffeine) significantly (p<0.05) increased plasma Peptide F ir values during exercise at chronic altitude only. Caffeine ingestion significantly increased plasma Peptide F ir concentrations during exercise and in the postexercise period at sea level. Conversely caffeine ingestion at altitude resulted in significant reductions in the postexercise plasma Peptide F ir values. The results of this study demonstrate that the exercise and recovery response patterns of plasma Peptide F ir may be significantly altered by altitude exposure and caffeine ingestion. These data support further study examining relationships between Peptide F (and other enkephalin-containing polypeptides) and epinephrine release in response to these types of physiological stresses.

Original languageEnglish
Pages (from-to)1115-1119
Number of pages5
JournalPeptides
Volume9
Issue number5
DOIs
StatePublished - 1 Jan 1988

Fingerprint

Caffeine
Exercise
Plasmas
Eating
Sea level
Oceans and Seas
Placebos
Physiological Stress
Enkephalins
Exercise Test
Design of experiments
Epinephrine
peptide F
Healthy Volunteers
Research Design
Recovery
Peptides

Keywords

  • Altitude acclimatization
  • Caffeine
  • Cardiovascular
  • Endogenous opioid peptides
  • Endurance exercise
  • Lactate

Cite this

Kraemer, W. J., Rock, P., Fulco, C. S., Gordon, S. E., Bonner, J. P., Cruthirds, C. D., ... Cymerman, A. (1988). Influence of altitude and caffeine during rest and exercise on plasma levels of proenkephalin Peptide F. Peptides, 9(5), 1115-1119. https://doi.org/10.1016/0196-9781(88)90098-8
Kraemer, William J. ; Rock, Paul ; Fulco, Charles S. ; Gordon, Scott E. ; Bonner, Jeff P. ; Cruthirds, Charles D. ; Marchitelli, Louis J. ; Trad, Laurie ; Cymerman, Allen. / Influence of altitude and caffeine during rest and exercise on plasma levels of proenkephalin Peptide F. In: Peptides. 1988 ; Vol. 9, No. 5. pp. 1115-1119.
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abstract = "The purpose of this study was to examine the resting and exercise response patterns of plasma Peptide F immunoreactivity (ir) to altitude exposure (4300 m) and caffeine ingestion (4 mg·kg b.w.-1). Nine healthy male subjects performed exercise tests to exhaustion (80-85{\%} VO2max) at sea level (50 m), during an acute altitude exposure (1 hr, hypobaric chamber, 4300 m) and after a chronic (17-day sojourn, 4300 m) altitude exposure. Using a randomized, double-blind/placebo experimental design, a placebo or caffeine drink was ingested 1 hour prior to exercise. Exercise (without caffeine) significantly (p<0.05) increased plasma Peptide F ir values during exercise at chronic altitude only. Caffeine ingestion significantly increased plasma Peptide F ir concentrations during exercise and in the postexercise period at sea level. Conversely caffeine ingestion at altitude resulted in significant reductions in the postexercise plasma Peptide F ir values. The results of this study demonstrate that the exercise and recovery response patterns of plasma Peptide F ir may be significantly altered by altitude exposure and caffeine ingestion. These data support further study examining relationships between Peptide F (and other enkephalin-containing polypeptides) and epinephrine release in response to these types of physiological stresses.",
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Kraemer, WJ, Rock, P, Fulco, CS, Gordon, SE, Bonner, JP, Cruthirds, CD, Marchitelli, LJ, Trad, L & Cymerman, A 1988, 'Influence of altitude and caffeine during rest and exercise on plasma levels of proenkephalin Peptide F', Peptides, vol. 9, no. 5, pp. 1115-1119. https://doi.org/10.1016/0196-9781(88)90098-8

Influence of altitude and caffeine during rest and exercise on plasma levels of proenkephalin Peptide F. / Kraemer, William J.; Rock, Paul; Fulco, Charles S.; Gordon, Scott E.; Bonner, Jeff P.; Cruthirds, Charles D.; Marchitelli, Louis J.; Trad, Laurie; Cymerman, Allen.

In: Peptides, Vol. 9, No. 5, 01.01.1988, p. 1115-1119.

Research output: Contribution to journalArticle

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T1 - Influence of altitude and caffeine during rest and exercise on plasma levels of proenkephalin Peptide F

AU - Kraemer, William J.

AU - Rock, Paul

AU - Fulco, Charles S.

AU - Gordon, Scott E.

AU - Bonner, Jeff P.

AU - Cruthirds, Charles D.

AU - Marchitelli, Louis J.

AU - Trad, Laurie

AU - Cymerman, Allen

PY - 1988/1/1

Y1 - 1988/1/1

N2 - The purpose of this study was to examine the resting and exercise response patterns of plasma Peptide F immunoreactivity (ir) to altitude exposure (4300 m) and caffeine ingestion (4 mg·kg b.w.-1). Nine healthy male subjects performed exercise tests to exhaustion (80-85% VO2max) at sea level (50 m), during an acute altitude exposure (1 hr, hypobaric chamber, 4300 m) and after a chronic (17-day sojourn, 4300 m) altitude exposure. Using a randomized, double-blind/placebo experimental design, a placebo or caffeine drink was ingested 1 hour prior to exercise. Exercise (without caffeine) significantly (p<0.05) increased plasma Peptide F ir values during exercise at chronic altitude only. Caffeine ingestion significantly increased plasma Peptide F ir concentrations during exercise and in the postexercise period at sea level. Conversely caffeine ingestion at altitude resulted in significant reductions in the postexercise plasma Peptide F ir values. The results of this study demonstrate that the exercise and recovery response patterns of plasma Peptide F ir may be significantly altered by altitude exposure and caffeine ingestion. These data support further study examining relationships between Peptide F (and other enkephalin-containing polypeptides) and epinephrine release in response to these types of physiological stresses.

AB - The purpose of this study was to examine the resting and exercise response patterns of plasma Peptide F immunoreactivity (ir) to altitude exposure (4300 m) and caffeine ingestion (4 mg·kg b.w.-1). Nine healthy male subjects performed exercise tests to exhaustion (80-85% VO2max) at sea level (50 m), during an acute altitude exposure (1 hr, hypobaric chamber, 4300 m) and after a chronic (17-day sojourn, 4300 m) altitude exposure. Using a randomized, double-blind/placebo experimental design, a placebo or caffeine drink was ingested 1 hour prior to exercise. Exercise (without caffeine) significantly (p<0.05) increased plasma Peptide F ir values during exercise at chronic altitude only. Caffeine ingestion significantly increased plasma Peptide F ir concentrations during exercise and in the postexercise period at sea level. Conversely caffeine ingestion at altitude resulted in significant reductions in the postexercise plasma Peptide F ir values. The results of this study demonstrate that the exercise and recovery response patterns of plasma Peptide F ir may be significantly altered by altitude exposure and caffeine ingestion. These data support further study examining relationships between Peptide F (and other enkephalin-containing polypeptides) and epinephrine release in response to these types of physiological stresses.

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KW - Caffeine

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KW - Endogenous opioid peptides

KW - Endurance exercise

KW - Lactate

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