Inactivation of the phospholipase B gene PLB5 in wild-type Candida albicans reduces cell-associated phospholipase A₂ activity and attenuates virulence

Keyphrases

• Virulence 100%
• Candida Albicans (C. albicans) 100%
• Phospholipase 100%
• Multigene Family 100%
• Phospholipase A2 Activity 100%
• Phospholipase B 100%
• Cell-Associated 100%
• Phospholipids 50%
• Opportunistic Fungal Pathogen 50%
• Physiologically Relevant 50%
• Filamentous Growth 50%
• Gene Activity 50%
• Environmental Conditions 50%
• Virulence Potential 50%
• Revertant 50%
• Secretory Proteins 50%
• Null mutant 50%
• Real-time RT-PCR 50%
• Virulence Determinants 50%
• Organ Colonization 50%
• Membrane Remodeling 50%
• Substrate Membrane 50%
• GPI-anchored Protein (GPI-AP) 50%
• Ester Bond 50%
• Attachment Site 50%
• Acyl Esters 50%
• Lipid Hydrolase 50%
• Gene Family Member 50%
• Hydrolytic Activity 50%
• Microbial Virulence 50%
• Transacylase 50%
• Gene Expression Analysis 50%
• Lysophospholipase 50%
• Substrate Specificity 50%
• Lysophospholipids 50%
• Lipid Substrate 50%

Biochemistry, Genetics and Molecular Biology

• Phospholipase A2 100%
• Candida Albicans 100%
• Wild Type 100%
• Multigene Family 100%
• Lysophospholipase 100%
• Phospholipase 66%
• Infectious Agent 33%
• Lipid 33%
• Gene Activity 33%
• Triacylglycerol Lipase 33%
• Pancreatic Lipase 33%
• Revertant 33%
• Secretory Protein 33%
• Quantitative Reverse Transcription Polymerase Chain Reaction 33%
• Enzyme Specificity 33%
• Acyltransferase 33%
• Gene Expression Profiling 33%
• Hydrolase 33%
• N-Acetyltransferase 33%
• Phospholipid 33%

Immunology and Microbiology

• Wild Type 100%
• Candida Albicans 100%
• Multigene Family 100%
• Infectious Agent 33%
• Revertant 33%
• Secretory Protein 33%
• Gene Activity 33%
• Quantitative Reverse Transcription Polymerase Chain Reaction 33%
• Enzyme Specificity 33%
• Gene Expression Assay 33%