Impaired osmoregulatory responses in rats with area postrema lesions

Kathleen Curtis, Wan Huang, Alan F. Sved, Joseph G. Verbalis, Edward M. Stricker

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Area postrema lesions (APX) in adult male rats produced a robust spontaneous intake of 0.5 M NaCl, as reported previously. The largest NaCl intakes (up to 108 ml/day) were observed when there was little incidental damage in the medial subnucleus of the nucleus of the solitary tract adjacent to the caudal and middle portions of the area postrema. Rats with discrete APX also drank substantial amounts of 0.5 M NaCl when access to saline was restricted to 7 h/day (up to 30 ml in 1 h, 48 ml in 7 h). Such large NaCl intakes stimulated considerable water ingestion and renal sodium excretion, but together these responses usually were insufficient for osmoregulation during the 7-h test period. After systemic administration of hypertonic NaCl solution, rats with APX excreted less Na+ in urine and secreted less vasopressin and oxytocin than control rats did. The prominent salt appetite, insufficient thirst and natriuresis in response to an ingested NaCl load, and blunted natriuresis and neurohypophysial hormone secretion in response to an injected NaCl load, all indicate that osmoregulatory responses are impaired in rats after APX.

Original languageEnglish
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume277
Issue number1 46-1
StatePublished - 1 Jul 1999

Fingerprint

Area Postrema
Natriuresis
Posterior Pituitary Hormones
Hypertonic Solutions
Osmoregulation
Thirst
Solitary Nucleus
Appetite
Oxytocin
Vasopressins
Salts
Eating
Sodium
Urine
Water

Keywords

  • Nucleus of the solitary tract
  • Oxytocin
  • Salt appetite
  • Thirst
  • Vasopressin

Cite this

Curtis, Kathleen ; Huang, Wan ; Sved, Alan F. ; Verbalis, Joseph G. ; Stricker, Edward M. / Impaired osmoregulatory responses in rats with area postrema lesions. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 1999 ; Vol. 277, No. 1 46-1.
@article{71a0b28ecc4a42f89c33d982e9c5e4d3,
title = "Impaired osmoregulatory responses in rats with area postrema lesions",
abstract = "Area postrema lesions (APX) in adult male rats produced a robust spontaneous intake of 0.5 M NaCl, as reported previously. The largest NaCl intakes (up to 108 ml/day) were observed when there was little incidental damage in the medial subnucleus of the nucleus of the solitary tract adjacent to the caudal and middle portions of the area postrema. Rats with discrete APX also drank substantial amounts of 0.5 M NaCl when access to saline was restricted to 7 h/day (up to 30 ml in 1 h, 48 ml in 7 h). Such large NaCl intakes stimulated considerable water ingestion and renal sodium excretion, but together these responses usually were insufficient for osmoregulation during the 7-h test period. After systemic administration of hypertonic NaCl solution, rats with APX excreted less Na+ in urine and secreted less vasopressin and oxytocin than control rats did. The prominent salt appetite, insufficient thirst and natriuresis in response to an ingested NaCl load, and blunted natriuresis and neurohypophysial hormone secretion in response to an injected NaCl load, all indicate that osmoregulatory responses are impaired in rats after APX.",
keywords = "Nucleus of the solitary tract, Oxytocin, Salt appetite, Thirst, Vasopressin",
author = "Kathleen Curtis and Wan Huang and Sved, {Alan F.} and Verbalis, {Joseph G.} and Stricker, {Edward M.}",
year = "1999",
month = "7",
day = "1",
language = "English",
volume = "277",
journal = "American Journal of Physiology - Regulatory Integrative and Comparative Physiology",
issn = "0002-9513",
publisher = "American Physiological Society",
number = "1 46-1",

}

Impaired osmoregulatory responses in rats with area postrema lesions. / Curtis, Kathleen; Huang, Wan; Sved, Alan F.; Verbalis, Joseph G.; Stricker, Edward M.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 277, No. 1 46-1, 01.07.1999.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impaired osmoregulatory responses in rats with area postrema lesions

AU - Curtis, Kathleen

AU - Huang, Wan

AU - Sved, Alan F.

AU - Verbalis, Joseph G.

AU - Stricker, Edward M.

PY - 1999/7/1

Y1 - 1999/7/1

N2 - Area postrema lesions (APX) in adult male rats produced a robust spontaneous intake of 0.5 M NaCl, as reported previously. The largest NaCl intakes (up to 108 ml/day) were observed when there was little incidental damage in the medial subnucleus of the nucleus of the solitary tract adjacent to the caudal and middle portions of the area postrema. Rats with discrete APX also drank substantial amounts of 0.5 M NaCl when access to saline was restricted to 7 h/day (up to 30 ml in 1 h, 48 ml in 7 h). Such large NaCl intakes stimulated considerable water ingestion and renal sodium excretion, but together these responses usually were insufficient for osmoregulation during the 7-h test period. After systemic administration of hypertonic NaCl solution, rats with APX excreted less Na+ in urine and secreted less vasopressin and oxytocin than control rats did. The prominent salt appetite, insufficient thirst and natriuresis in response to an ingested NaCl load, and blunted natriuresis and neurohypophysial hormone secretion in response to an injected NaCl load, all indicate that osmoregulatory responses are impaired in rats after APX.

AB - Area postrema lesions (APX) in adult male rats produced a robust spontaneous intake of 0.5 M NaCl, as reported previously. The largest NaCl intakes (up to 108 ml/day) were observed when there was little incidental damage in the medial subnucleus of the nucleus of the solitary tract adjacent to the caudal and middle portions of the area postrema. Rats with discrete APX also drank substantial amounts of 0.5 M NaCl when access to saline was restricted to 7 h/day (up to 30 ml in 1 h, 48 ml in 7 h). Such large NaCl intakes stimulated considerable water ingestion and renal sodium excretion, but together these responses usually were insufficient for osmoregulation during the 7-h test period. After systemic administration of hypertonic NaCl solution, rats with APX excreted less Na+ in urine and secreted less vasopressin and oxytocin than control rats did. The prominent salt appetite, insufficient thirst and natriuresis in response to an ingested NaCl load, and blunted natriuresis and neurohypophysial hormone secretion in response to an injected NaCl load, all indicate that osmoregulatory responses are impaired in rats after APX.

KW - Nucleus of the solitary tract

KW - Oxytocin

KW - Salt appetite

KW - Thirst

KW - Vasopressin

UR - http://www.scopus.com/inward/record.url?scp=0032767729&partnerID=8YFLogxK

M3 - Article

C2 - 10409275

AN - SCOPUS:0032767729

VL - 277

JO - American Journal of Physiology - Regulatory Integrative and Comparative Physiology

JF - American Journal of Physiology - Regulatory Integrative and Comparative Physiology

SN - 0002-9513

IS - 1 46-1

ER -