Impact of social defeat on NF-KB p-65 activation in liver: A study in C57BL/6J male mice

Nadesh Vaithianathan, Kelly McCracken, B. Daniel, Randall Davis

Research output: Contribution to conferencePoster

Abstract

An increase in mood and anxiety disorders causes a demand to invent new medications and treatment strategies to reduce neuroinflammation in the brain and liver. The drug of interest, β-funaltrexamine (β-FNA) has shown to reduce jauntiness behavior in mice from a previous experiment. We currently are determining if Social Stress increases when a different strain or the same strain of mouse is introduced into the community of mice. This project, Repeated Social Defeat (RSD) has 2 test groups, Single Bout of Social Defeat and RSD to analyze different stress levels through NF-κB p65 Activation levels. This activation level was determined by using Western Blot Analysis. The Results of this experiment showed that the community of mice had increased stress levels regardless of the strain of mice. This experiment will be a footstep for the upcoming implementation of β-FNA as a therapeutic drug.
Original languageAmerican English
StatePublished - 4 Sep 2020
EventOklahoma State University Center for Health Sciences Research Day 2020 - Oklahoma State University Center for Health Sciences College of Osteopathic Medicine, Tulsa, United States
Duration: 27 Feb 202028 Feb 2020

Conference

ConferenceOklahoma State University Center for Health Sciences Research Day 2020
CountryUnited States
CityTulsa
Period27/02/2028/02/20

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    Vaithianathan, N., McCracken, K., Daniel, B., & Davis, R. (2020). Impact of social defeat on NF-KB p-65 activation in liver: A study in C57BL/6J male mice. Poster session presented at Oklahoma State University Center for Health Sciences Research Day 2020, Tulsa, United States. https://shareok.org/handle/11244/324259