IL1A rs1800587 associates with chronic noncrisis pain in sickle cell disease

Xiaoyu Hu; Ellie H. Jhun; Yingwei Yao; Ying He; Robert E. Molokie; DIana J. Wilkie; Zaijie J. Wang

doi:10.2217/pgs-2016-0085

IL1A rs1800587 associates with chronic noncrisis pain in sickle cell disease

Xiaoyu Hu, Ellie H. Jhun, Yingwei Yao, Ying He, Robert E. Molokie, DIana J. Wilkie, Zaijie J. Wang

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Aim: Pain is prevalent in sickle cell disease (SCD) patients who display great heterogeneity in pain severity and frequency. Hypothesizing that inflammatory factors are involved in the pathogenesis of SCD pain, we focused on the IL1A C/T polymorphism rs1800587 that is an SNP located in a cis-transcriptional regulatory region. Methods: We genotyped IL1A rs1800587 and performed association studies with phenotype data obtained by a multidimensional pain assessment tool using the PAINReportIt^® Questionnaire. Results: Each T allele was associated with a 3.9 increase in composite pain index score (p = 0.04) as determined by multiple linear regression. Conclusion: IL1A rs1800587 may influence chronic pain in SCD.

Original language	English
Pages (from-to)	1999-2006
Number of pages	8
Journal	Pharmacogenomics
Volume	17
Issue number	18
DOIs	https://doi.org/10.2217/pgs-2016-0085
State	Published - Dec 2016
Externally published	Yes

Keywords

chronic
inflammation
interleukin
pain
pain crisis
polymorphism
promoter
sickle cell
transcription

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title = "IL1A rs1800587 associates with chronic noncrisis pain in sickle cell disease",

abstract = "Aim: Pain is prevalent in sickle cell disease (SCD) patients who display great heterogeneity in pain severity and frequency. Hypothesizing that inflammatory factors are involved in the pathogenesis of SCD pain, we focused on the IL1A C/T polymorphism rs1800587 that is an SNP located in a cis-transcriptional regulatory region. Methods: We genotyped IL1A rs1800587 and performed association studies with phenotype data obtained by a multidimensional pain assessment tool using the PAINReportIt{\textregistered} Questionnaire. Results: Each T allele was associated with a 3.9 increase in composite pain index score (p = 0.04) as determined by multiple linear regression. Conclusion: IL1A rs1800587 may influence chronic pain in SCD.",

keywords = "chronic, inflammation, interleukin, pain, pain crisis, polymorphism, promoter, sickle cell, transcription",

author = "Xiaoyu Hu and Jhun, {Ellie H.} and Yingwei Yao and Ying He and Molokie, {Robert E.} and Wilkie, {DIana J.} and Wang, {Zaijie J.}",

note = "Publisher Copyright: {\textcopyright} 2016 Future Medicine Ltd.",

year = "2016",

month = dec,

doi = "10.2217/pgs-2016-0085",

language = "English",

volume = "17",

pages = "1999--2006",

journal = "Pharmacogenomics",

issn = "1462-2416",

publisher = "Future Medicine Ltd.",

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TY - JOUR

T1 - IL1A rs1800587 associates with chronic noncrisis pain in sickle cell disease

AU - Hu, Xiaoyu

AU - Jhun, Ellie H.

AU - Yao, Yingwei

AU - He, Ying

AU - Molokie, Robert E.

AU - Wilkie, DIana J.

AU - Wang, Zaijie J.

PY - 2016/12

Y1 - 2016/12

N2 - Aim: Pain is prevalent in sickle cell disease (SCD) patients who display great heterogeneity in pain severity and frequency. Hypothesizing that inflammatory factors are involved in the pathogenesis of SCD pain, we focused on the IL1A C/T polymorphism rs1800587 that is an SNP located in a cis-transcriptional regulatory region. Methods: We genotyped IL1A rs1800587 and performed association studies with phenotype data obtained by a multidimensional pain assessment tool using the PAINReportIt® Questionnaire. Results: Each T allele was associated with a 3.9 increase in composite pain index score (p = 0.04) as determined by multiple linear regression. Conclusion: IL1A rs1800587 may influence chronic pain in SCD.

AB - Aim: Pain is prevalent in sickle cell disease (SCD) patients who display great heterogeneity in pain severity and frequency. Hypothesizing that inflammatory factors are involved in the pathogenesis of SCD pain, we focused on the IL1A C/T polymorphism rs1800587 that is an SNP located in a cis-transcriptional regulatory region. Methods: We genotyped IL1A rs1800587 and performed association studies with phenotype data obtained by a multidimensional pain assessment tool using the PAINReportIt® Questionnaire. Results: Each T allele was associated with a 3.9 increase in composite pain index score (p = 0.04) as determined by multiple linear regression. Conclusion: IL1A rs1800587 may influence chronic pain in SCD.

KW - chronic

KW - inflammation

KW - interleukin

KW - pain

KW - pain crisis

KW - polymorphism

KW - promoter

KW - sickle cell

KW - transcription

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U2 - 10.2217/pgs-2016-0085

DO - 10.2217/pgs-2016-0085

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SN - 1462-2416

VL - 17

SP - 1999

EP - 2006

JO - Pharmacogenomics

JF - Pharmacogenomics

IS - 18

ER -

IL1A rs1800587 associates with chronic noncrisis pain in sickle cell disease

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Keywords

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