IL1A rs1800587 associates with chronic noncrisis pain in sickle cell disease

Xiaoyu Hu, Ellie H. Jhun, Yingwei Yao, Ying He, Robert E. Molokie, DIana J. Wilkie, Zaijie J. Wang

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Aim: Pain is prevalent in sickle cell disease (SCD) patients who display great heterogeneity in pain severity and frequency. Hypothesizing that inflammatory factors are involved in the pathogenesis of SCD pain, we focused on the IL1A C/T polymorphism rs1800587 that is an SNP located in a cis-transcriptional regulatory region. Methods: We genotyped IL1A rs1800587 and performed association studies with phenotype data obtained by a multidimensional pain assessment tool using the PAINReportIt® Questionnaire. Results: Each T allele was associated with a 3.9 increase in composite pain index score (p = 0.04) as determined by multiple linear regression. Conclusion: IL1A rs1800587 may influence chronic pain in SCD.

Original languageEnglish
Pages (from-to)1999-2006
Number of pages8
JournalPharmacogenomics
Volume17
Issue number18
DOIs
StatePublished - Dec 2016
Externally publishedYes

Keywords

  • chronic
  • inflammation
  • interleukin
  • pain
  • pain crisis
  • polymorphism
  • promoter
  • sickle cell
  • transcription

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