Identification of two nervous system-specific members of the erg potassium channel gene family

Wenmei Shi, Randy S. Wymore, Hong Sheng Wang, Zongming Pan, Ira S. Cohen, David McKinnon, Jane E. Dixon

Research output: Contribution to journalArticle

167 Scopus citations

Abstract

Two new potassium channel genes, erg2 and erg3, that are expressed in the nervous system of the rat were identified. These two genes form a small gene family with the previously described erg1 (HERG) gene. The erg2 and erg3 genes are expressed exclusively in the nervous system, in marked contrast to erg1, which is expressed in both neural and non-neural tissues. All three genes are expressed in peripheral sympathetic ganglia. The erg3 channel produces a current that has a large transient component at positive potentials, whereas the other two channels are slowly activating delayed rectifiers. Expression of the erg1 gene in the sympathetic nervous system has potential implications for the etiology of the LQT2 form of the human genetic disease long QT syndrome.

Original languageEnglish
Pages (from-to)9423-9432
Number of pages10
JournalJournal of Neuroscience
Volume17
Issue number24
DOIs
StatePublished - 1997

Keywords

  • Delayed rectifier
  • Erg
  • Gene
  • Long QT syndrome
  • Potassium channel
  • Sympathetic neuron

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