Candida auris: A Comprehensive Analysis of Clinical Trials

Rachel Wilkins, Sarah Wilkinson, Eugenio Hernandez, Benjamin Greiner, Micah Hartwell

Research output: Contribution to conferencePosterpeer-review

Abstract

Purpose: Candida auris (C. auris) was initially isolated in 2009 and has increased its prevalence globally. Many strains exhibit multidrug resistance to primary antifungal treatments, causing difficulty for healthcare professionals and poor outcomes for patients. The purpose of this study is to analyze clinical trials regarding treatment of C. auris infections due to increasing antimicrobial resistance.

Methods: An observational analysis was conducted of clinical trials from two databases. The National Library of Medicine’s Clinical Trials (Clinicaltrials.gov) was analyzed using ‘Candida auris’ and ‘Invasive candidiasis’ with ‘C. auris’ in the ‘other’ field. MEDLINE (PubMed.gov) was analyzed using ‘clinical trial,’ ‘phase,’ and ‘candida auris.’

Results: The search of CTG resulted in 7 unique trials with 1 additional trial found on PubMed. From these trials, 5 were interventional studies that used one of the following medications: fosmanogepix, oral ibrexafungerp (SCY-078), rezafungin, caspofungin, fluconazole, and intranasal 10% povidone-iodine. From these 5 trials, 2 have results with antifungal treatments NCT04148287 and NCT03667690.

Discussion/Conclusion: Publishing the results of clinical trials promptly is necessary to increase the amount of therapeutic research and continue the education of healthcare professionals and patients. It is necessary for the development of an effective and safe cure for C. auris infections.
Original languageAmerican English
Pages65
StatePublished - 13 Sep 2024
Event2024 Symposium on Tribal and Rural Innovations in Disparities and Equity for Health - Oklahoma State University College of Osteopathic Medicine at the Cherokee Nation, Tahlequah, United States
Duration: 13 Sep 202413 Sep 2024

Conference

Conference2024 Symposium on Tribal and Rural Innovations in Disparities and Equity for Health
Abbreviated titleSTRIDE 2024
Country/TerritoryUnited States
CityTahlequah
Period13/09/2413/09/24

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