Hypoglycemia in lethal septic shock in subhuman primates

L. B. Hinshaw, Bruce Benjamin, J. J. Coalson

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Recent research in this laboratory has documented progressively developing hypoglycemia in canine endotoxin shock. The purpose of the present study was to test these findings in a subhuman primate. Experiments were conducted on fasted baboons, anesthetized with sodium pentobarbital and infused with live Escherichia coli organisms (1010 organisms/kg). Six of seven baboons died within 26 hours with a mean survival time of 15 hours. Mean systemic pressures declined gradually after onset of organism infusion. An initial variable period of hyperglycemia was observed in six animals followed by 4 to 15 hours of progessively developing hypoglycemia in all nonsurviving animals. Insulin values in arterial blood decreased markedly within 4 hours after E. coli infusion and remained low (10 to 20% of control) in all nonsurviving animals. Arterial blood lactate and serum potassium rose progressively in animals demonstrating the greatest degree of systemic hypotension, whereas pH remained relatively constant until preterminal periods.

Original languageEnglish
Pages (from-to)197-208
Number of pages12
JournalCirculatory Shock
Volume2
Issue number3
StatePublished - 1 Jan 1975

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Septic Shock
Hypoglycemia
Primates
Papio
Escherichia coli
Pentobarbital
Endotoxins
Hyperglycemia
Hypotension
Canidae
Shock
Lactic Acid
Potassium
Insulin
Pressure
Serum
Research

Cite this

Hinshaw, L. B., Benjamin, B., & Coalson, J. J. (1975). Hypoglycemia in lethal septic shock in subhuman primates. Circulatory Shock, 2(3), 197-208.
Hinshaw, L. B. ; Benjamin, Bruce ; Coalson, J. J. / Hypoglycemia in lethal septic shock in subhuman primates. In: Circulatory Shock. 1975 ; Vol. 2, No. 3. pp. 197-208.
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Hinshaw, LB, Benjamin, B & Coalson, JJ 1975, 'Hypoglycemia in lethal septic shock in subhuman primates', Circulatory Shock, vol. 2, no. 3, pp. 197-208.

Hypoglycemia in lethal septic shock in subhuman primates. / Hinshaw, L. B.; Benjamin, Bruce; Coalson, J. J.

In: Circulatory Shock, Vol. 2, No. 3, 01.01.1975, p. 197-208.

Research output: Contribution to journalArticle

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