Recent research in this laboratory has documented progressively developing hypoglycemia in canine endotoxin shock. The purpose of the present study was to test these findings in a subhuman primate. Experiments were conducted on fasted baboons, anesthetized with sodium pentobarbital and infused with live Escherichia coli organisms (1010 organisms/kg). Six of seven baboons died within 26 hours with a mean survival time of 15 hours. Mean systemic pressures declined gradually after onset of organism infusion. An initial variable period of hyperglycemia was observed in six animals followed by 4 to 15 hours of progessively developing hypoglycemia in all nonsurviving animals. Insulin values in arterial blood decreased markedly within 4 hours after E. coli infusion and remained low (10 to 20% of control) in all nonsurviving animals. Arterial blood lactate and serum potassium rose progressively in animals demonstrating the greatest degree of systemic hypotension, whereas pH remained relatively constant until preterminal periods.
|Number of pages
|Published - 1 Jan 1975