Higher Fasting Glucose Is Associated With Poorer Cognition Among Healthy Young Adults

Misty A.W. Hawkins, John Gunstad, Dayana Calvo, Mary Beth Spitznagel

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: Obesity is associated with cognitive deficits; however, the mechanisms are unclear, especially among otherwise healthy adults. Our objectives were to examine (a) whether obesity is linked to elevations in fasting glucose and (b) whether these elevations are associated with cognitive impairment among otherwise healthy young adults. Method: Participants were 35 normal weight adults and 35 young adults with obesity who completed a task from the Automated Neuropsychological Assessment Metrics-4 (ANAM-4). Measured body mass index (BMI) and fasting blood glucose levels (mg/dL) were examined. Results: Persons with obesity had higher fasting glucose levels than normal weight persons (p =.03). After applying Bonferroni correction for multiple tests, higher fasting glucose predicted less accurate performance on tests of inhibitory control: Go/No-Go Commission Errors (β =.33, p =.004). No effects were observed for sustained attention or working memory (ps ≥.049). Persons with glucose levels in the prediabetes range had nearly twice as many errors as those with normal glucose, a large effect that was independent of BMI. Conclusions: Young adults who were obese but otherwise healthy had higher fasting glucose levels compared with normal weight peers. Higher glucose levels were associated with poorer cognitive performance on tests of inhibitory control, especially among individuals with prediabetes levels. Thus, subclinical elevations in blood glucose may contribute to cognitive impairment and, ultimately, greater impulsivity- well in advance of the development of chronic disease states (e.g., insulin resistance or Type 2 diabetes) and independently of excess adiposity-though prospective studies are needed to determine directionality of this relationship.

Original languageEnglish
Pages (from-to)199-202
Number of pages4
JournalHealth Psychology
Volume35
Issue number2
DOIs
StatePublished - 1 Feb 2016
Externally publishedYes

Fingerprint

Cognition
Young Adult
Fasting
Glucose
Obesity
Prediabetic State
Weights and Measures
Blood Glucose
Body Mass Index
Impulsive Behavior
Adiposity
Short-Term Memory
Type 2 Diabetes Mellitus
Insulin Resistance
Chronic Disease
Prospective Studies

Keywords

  • Cognitive function
  • Fasting glucose
  • Glucoregulation
  • Inhibitory control
  • Obesity

Cite this

Hawkins, Misty A.W. ; Gunstad, John ; Calvo, Dayana ; Spitznagel, Mary Beth. / Higher Fasting Glucose Is Associated With Poorer Cognition Among Healthy Young Adults. In: Health Psychology. 2016 ; Vol. 35, No. 2. pp. 199-202.
@article{99a1f496ba554aa4a1b64558798bb934,
title = "Higher Fasting Glucose Is Associated With Poorer Cognition Among Healthy Young Adults",
abstract = "Objective: Obesity is associated with cognitive deficits; however, the mechanisms are unclear, especially among otherwise healthy adults. Our objectives were to examine (a) whether obesity is linked to elevations in fasting glucose and (b) whether these elevations are associated with cognitive impairment among otherwise healthy young adults. Method: Participants were 35 normal weight adults and 35 young adults with obesity who completed a task from the Automated Neuropsychological Assessment Metrics-4 (ANAM-4). Measured body mass index (BMI) and fasting blood glucose levels (mg/dL) were examined. Results: Persons with obesity had higher fasting glucose levels than normal weight persons (p =.03). After applying Bonferroni correction for multiple tests, higher fasting glucose predicted less accurate performance on tests of inhibitory control: Go/No-Go Commission Errors (β =.33, p =.004). No effects were observed for sustained attention or working memory (ps ≥.049). Persons with glucose levels in the prediabetes range had nearly twice as many errors as those with normal glucose, a large effect that was independent of BMI. Conclusions: Young adults who were obese but otherwise healthy had higher fasting glucose levels compared with normal weight peers. Higher glucose levels were associated with poorer cognitive performance on tests of inhibitory control, especially among individuals with prediabetes levels. Thus, subclinical elevations in blood glucose may contribute to cognitive impairment and, ultimately, greater impulsivity- well in advance of the development of chronic disease states (e.g., insulin resistance or Type 2 diabetes) and independently of excess adiposity-though prospective studies are needed to determine directionality of this relationship.",
keywords = "Cognitive function, Fasting glucose, Glucoregulation, Inhibitory control, Obesity",
author = "Hawkins, {Misty A.W.} and John Gunstad and Dayana Calvo and Spitznagel, {Mary Beth}",
year = "2016",
month = "2",
day = "1",
doi = "10.1037/hea0000248",
language = "English",
volume = "35",
pages = "199--202",
journal = "Health Psychology",
issn = "0278-6133",
publisher = "American Psychological Association Inc.",
number = "2",

}

Higher Fasting Glucose Is Associated With Poorer Cognition Among Healthy Young Adults. / Hawkins, Misty A.W.; Gunstad, John; Calvo, Dayana; Spitznagel, Mary Beth.

In: Health Psychology, Vol. 35, No. 2, 01.02.2016, p. 199-202.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Higher Fasting Glucose Is Associated With Poorer Cognition Among Healthy Young Adults

AU - Hawkins, Misty A.W.

AU - Gunstad, John

AU - Calvo, Dayana

AU - Spitznagel, Mary Beth

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Objective: Obesity is associated with cognitive deficits; however, the mechanisms are unclear, especially among otherwise healthy adults. Our objectives were to examine (a) whether obesity is linked to elevations in fasting glucose and (b) whether these elevations are associated with cognitive impairment among otherwise healthy young adults. Method: Participants were 35 normal weight adults and 35 young adults with obesity who completed a task from the Automated Neuropsychological Assessment Metrics-4 (ANAM-4). Measured body mass index (BMI) and fasting blood glucose levels (mg/dL) were examined. Results: Persons with obesity had higher fasting glucose levels than normal weight persons (p =.03). After applying Bonferroni correction for multiple tests, higher fasting glucose predicted less accurate performance on tests of inhibitory control: Go/No-Go Commission Errors (β =.33, p =.004). No effects were observed for sustained attention or working memory (ps ≥.049). Persons with glucose levels in the prediabetes range had nearly twice as many errors as those with normal glucose, a large effect that was independent of BMI. Conclusions: Young adults who were obese but otherwise healthy had higher fasting glucose levels compared with normal weight peers. Higher glucose levels were associated with poorer cognitive performance on tests of inhibitory control, especially among individuals with prediabetes levels. Thus, subclinical elevations in blood glucose may contribute to cognitive impairment and, ultimately, greater impulsivity- well in advance of the development of chronic disease states (e.g., insulin resistance or Type 2 diabetes) and independently of excess adiposity-though prospective studies are needed to determine directionality of this relationship.

AB - Objective: Obesity is associated with cognitive deficits; however, the mechanisms are unclear, especially among otherwise healthy adults. Our objectives were to examine (a) whether obesity is linked to elevations in fasting glucose and (b) whether these elevations are associated with cognitive impairment among otherwise healthy young adults. Method: Participants were 35 normal weight adults and 35 young adults with obesity who completed a task from the Automated Neuropsychological Assessment Metrics-4 (ANAM-4). Measured body mass index (BMI) and fasting blood glucose levels (mg/dL) were examined. Results: Persons with obesity had higher fasting glucose levels than normal weight persons (p =.03). After applying Bonferroni correction for multiple tests, higher fasting glucose predicted less accurate performance on tests of inhibitory control: Go/No-Go Commission Errors (β =.33, p =.004). No effects were observed for sustained attention or working memory (ps ≥.049). Persons with glucose levels in the prediabetes range had nearly twice as many errors as those with normal glucose, a large effect that was independent of BMI. Conclusions: Young adults who were obese but otherwise healthy had higher fasting glucose levels compared with normal weight peers. Higher glucose levels were associated with poorer cognitive performance on tests of inhibitory control, especially among individuals with prediabetes levels. Thus, subclinical elevations in blood glucose may contribute to cognitive impairment and, ultimately, greater impulsivity- well in advance of the development of chronic disease states (e.g., insulin resistance or Type 2 diabetes) and independently of excess adiposity-though prospective studies are needed to determine directionality of this relationship.

KW - Cognitive function

KW - Fasting glucose

KW - Glucoregulation

KW - Inhibitory control

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=84955367253&partnerID=8YFLogxK

U2 - 10.1037/hea0000248

DO - 10.1037/hea0000248

M3 - Article

C2 - 26523354

AN - SCOPUS:84955367253

VL - 35

SP - 199

EP - 202

JO - Health Psychology

JF - Health Psychology

SN - 0278-6133

IS - 2

ER -