Glutaminase immunoreactive neurons in the rat dorsal root ganglion contain calcitonin gene-related peptide (CGRP)

Kenneth E. Miller, Vickie D. Douglas, Takeshi Kaneko

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The co-localization of glutaminase and calcitonin gene-related peptide (CGRP) was examined with immunohistochemistry in the rat dorsal root ganglion (DRG). The majority of the DRG neurons were immunoreactive for glutaminase and all DRG neurons that contained CGRP also contained glutaminase. These results indicate that some DRG neurons release glutamate and CGRP from the same axon terminals in the spinal cord. Co-release of glutamate and CGRP from primary afferents may have multiple effects including fast and slow neurotransmission of sensory information in the spinal cord.

Original languageEnglish
Pages (from-to)113-116
Number of pages4
JournalNeuroscience Letters
Volume160
Issue number1
DOIs
StatePublished - 17 Sep 1993

Fingerprint

Glutaminase
Calcitonin Gene-Related Peptide
Spinal Ganglia
Neurons
Glutamic Acid
Spinal Cord
Presynaptic Terminals
Synaptic Transmission
Immunohistochemistry

Keywords

  • Co-localization
  • Dorsal horn
  • Excitatory amino acid
  • Glutamate
  • Primary afferent

Cite this

@article{3b82cbb0ac6443abb5da606da5a85f0c,
title = "Glutaminase immunoreactive neurons in the rat dorsal root ganglion contain calcitonin gene-related peptide (CGRP)",
abstract = "The co-localization of glutaminase and calcitonin gene-related peptide (CGRP) was examined with immunohistochemistry in the rat dorsal root ganglion (DRG). The majority of the DRG neurons were immunoreactive for glutaminase and all DRG neurons that contained CGRP also contained glutaminase. These results indicate that some DRG neurons release glutamate and CGRP from the same axon terminals in the spinal cord. Co-release of glutamate and CGRP from primary afferents may have multiple effects including fast and slow neurotransmission of sensory information in the spinal cord.",
keywords = "Co-localization, Dorsal horn, Excitatory amino acid, Glutamate, Primary afferent",
author = "Miller, {Kenneth E.} and Douglas, {Vickie D.} and Takeshi Kaneko",
year = "1993",
month = "9",
day = "17",
doi = "10.1016/0304-3940(93)90926-C",
language = "English",
volume = "160",
pages = "113--116",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

Glutaminase immunoreactive neurons in the rat dorsal root ganglion contain calcitonin gene-related peptide (CGRP). / Miller, Kenneth E.; Douglas, Vickie D.; Kaneko, Takeshi.

In: Neuroscience Letters, Vol. 160, No. 1, 17.09.1993, p. 113-116.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Glutaminase immunoreactive neurons in the rat dorsal root ganglion contain calcitonin gene-related peptide (CGRP)

AU - Miller, Kenneth E.

AU - Douglas, Vickie D.

AU - Kaneko, Takeshi

PY - 1993/9/17

Y1 - 1993/9/17

N2 - The co-localization of glutaminase and calcitonin gene-related peptide (CGRP) was examined with immunohistochemistry in the rat dorsal root ganglion (DRG). The majority of the DRG neurons were immunoreactive for glutaminase and all DRG neurons that contained CGRP also contained glutaminase. These results indicate that some DRG neurons release glutamate and CGRP from the same axon terminals in the spinal cord. Co-release of glutamate and CGRP from primary afferents may have multiple effects including fast and slow neurotransmission of sensory information in the spinal cord.

AB - The co-localization of glutaminase and calcitonin gene-related peptide (CGRP) was examined with immunohistochemistry in the rat dorsal root ganglion (DRG). The majority of the DRG neurons were immunoreactive for glutaminase and all DRG neurons that contained CGRP also contained glutaminase. These results indicate that some DRG neurons release glutamate and CGRP from the same axon terminals in the spinal cord. Co-release of glutamate and CGRP from primary afferents may have multiple effects including fast and slow neurotransmission of sensory information in the spinal cord.

KW - Co-localization

KW - Dorsal horn

KW - Excitatory amino acid

KW - Glutamate

KW - Primary afferent

UR - http://www.scopus.com/inward/record.url?scp=0027430283&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(93)90926-C

DO - 10.1016/0304-3940(93)90926-C

M3 - Article

C2 - 8247321

AN - SCOPUS:0027430283

VL - 160

SP - 113

EP - 116

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1

ER -