Glutaminase immunoreactive neurons in the rat dorsal root ganglion contain calcitonin gene-related peptide (CGRP)

Kenneth E. Miller, Vickie D. Douglas, Takeshi Kaneko

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The co-localization of glutaminase and calcitonin gene-related peptide (CGRP) was examined with immunohistochemistry in the rat dorsal root ganglion (DRG). The majority of the DRG neurons were immunoreactive for glutaminase and all DRG neurons that contained CGRP also contained glutaminase. These results indicate that some DRG neurons release glutamate and CGRP from the same axon terminals in the spinal cord. Co-release of glutamate and CGRP from primary afferents may have multiple effects including fast and slow neurotransmission of sensory information in the spinal cord.

Original languageEnglish
Pages (from-to)113-116
Number of pages4
JournalNeuroscience Letters
Issue number1
StatePublished - 17 Sep 1993



  • Co-localization
  • Dorsal horn
  • Excitatory amino acid
  • Glutamate
  • Primary afferent

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