Glutaminase immunoreactive neurons in the rat dorsal root ganglion contain calcitonin gene-related peptide (CGRP)

Kenneth E. Miller; Vickie D. Douglas; Takeshi Kaneko

doi:10.1016/0304-3940(93)90926-C

Glutaminase immunoreactive neurons in the rat dorsal root ganglion contain calcitonin gene-related peptide (CGRP)

Kenneth E. Miller, Vickie D. Douglas, Takeshi Kaneko

Anatomy and Cell Biology

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The co-localization of glutaminase and calcitonin gene-related peptide (CGRP) was examined with immunohistochemistry in the rat dorsal root ganglion (DRG). The majority of the DRG neurons were immunoreactive for glutaminase and all DRG neurons that contained CGRP also contained glutaminase. These results indicate that some DRG neurons release glutamate and CGRP from the same axon terminals in the spinal cord. Co-release of glutamate and CGRP from primary afferents may have multiple effects including fast and slow neurotransmission of sensory information in the spinal cord.

Original language	English
Pages (from-to)	113-116
Number of pages	4
Journal	Neuroscience Letters
Volume	160
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(93)90926-C
State	Published - 17 Sep 1993

Keywords

Co-localization
Dorsal horn
Excitatory amino acid
Glutamate
Primary afferent

Access to Document

10.1016/0304-3940(93)90926-C

Cite this

@article{3b82cbb0ac6443abb5da606da5a85f0c,

title = "Glutaminase immunoreactive neurons in the rat dorsal root ganglion contain calcitonin gene-related peptide (CGRP)",

abstract = "The co-localization of glutaminase and calcitonin gene-related peptide (CGRP) was examined with immunohistochemistry in the rat dorsal root ganglion (DRG). The majority of the DRG neurons were immunoreactive for glutaminase and all DRG neurons that contained CGRP also contained glutaminase. These results indicate that some DRG neurons release glutamate and CGRP from the same axon terminals in the spinal cord. Co-release of glutamate and CGRP from primary afferents may have multiple effects including fast and slow neurotransmission of sensory information in the spinal cord.",

keywords = "Co-localization, Dorsal horn, Excitatory amino acid, Glutamate, Primary afferent",

author = "Miller, {Kenneth E.} and Douglas, {Vickie D.} and Takeshi Kaneko",

year = "1993",

month = sep,

day = "17",

doi = "10.1016/0304-3940(93)90926-C",

language = "English",

volume = "160",

pages = "113--116",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Glutaminase immunoreactive neurons in the rat dorsal root ganglion contain calcitonin gene-related peptide (CGRP)

AU - Miller, Kenneth E.

AU - Douglas, Vickie D.

AU - Kaneko, Takeshi

PY - 1993/9/17

Y1 - 1993/9/17

N2 - The co-localization of glutaminase and calcitonin gene-related peptide (CGRP) was examined with immunohistochemistry in the rat dorsal root ganglion (DRG). The majority of the DRG neurons were immunoreactive for glutaminase and all DRG neurons that contained CGRP also contained glutaminase. These results indicate that some DRG neurons release glutamate and CGRP from the same axon terminals in the spinal cord. Co-release of glutamate and CGRP from primary afferents may have multiple effects including fast and slow neurotransmission of sensory information in the spinal cord.

AB - The co-localization of glutaminase and calcitonin gene-related peptide (CGRP) was examined with immunohistochemistry in the rat dorsal root ganglion (DRG). The majority of the DRG neurons were immunoreactive for glutaminase and all DRG neurons that contained CGRP also contained glutaminase. These results indicate that some DRG neurons release glutamate and CGRP from the same axon terminals in the spinal cord. Co-release of glutamate and CGRP from primary afferents may have multiple effects including fast and slow neurotransmission of sensory information in the spinal cord.

KW - Co-localization

KW - Dorsal horn

KW - Excitatory amino acid

KW - Glutamate

KW - Primary afferent

UR - http://www.scopus.com/inward/record.url?scp=0027430283&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(93)90926-C

DO - 10.1016/0304-3940(93)90926-C

M3 - Article

C2 - 8247321

AN - SCOPUS:0027430283

SN - 0304-3940

VL - 160

SP - 113

EP - 116

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Glutaminase immunoreactive neurons in the rat dorsal root ganglion contain calcitonin gene-related peptide (CGRP)

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this