Glutaminase immunoreactive neurons in the rat dorsal root ganglion contain calcitonin gene-related peptide (CGRP)

Kenneth E. Miller, Vickie D. Douglas, Takeshi Kaneko

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The co-localization of glutaminase and calcitonin gene-related peptide (CGRP) was examined with immunohistochemistry in the rat dorsal root ganglion (DRG). The majority of the DRG neurons were immunoreactive for glutaminase and all DRG neurons that contained CGRP also contained glutaminase. These results indicate that some DRG neurons release glutamate and CGRP from the same axon terminals in the spinal cord. Co-release of glutamate and CGRP from primary afferents may have multiple effects including fast and slow neurotransmission of sensory information in the spinal cord.

Original languageEnglish
Pages (from-to)113-116
Number of pages4
JournalNeuroscience Letters
Volume160
Issue number1
DOIs
StatePublished - 17 Sep 1993

Keywords

  • Co-localization
  • Dorsal horn
  • Excitatory amino acid
  • Glutamate
  • Primary afferent

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