@article{e63b2cd3d12e4e96a97b304cb2ac6ad7,
title = "Glucocorticoid receptor single nucleotide polymorphisms are associated with acute crisis pain in sickle cell disease",
abstract = "Aim: Pain in sickle cell disease patients is heterogeneous and genetic polymorphisms may predispose an individual to varied vulnerability to painful events. We studied the association of SNPs in the glucocorticoid receptor gene (NR3C1) with pain in sickle cell disease. Method: Acute pain was scored as the number of utilizations due to crisis pain in a 12-month period. Chronic pain was calculated as the Composite Pain Index score. Results & conclusion: Rs33389 T allele (IRR = 1.53, p = 0.014 additive; IRR = 1.64, p = 0.011 recessive), rs2963155 G allele (IRR = 1.80, p < 0.001 additive; IRR = 2.25, p = 0.021 dominant; IRR = 2.07, p < 0.001 recessive) and rs9324918 C allele (IRR = 1.43, p = 0.021 additive) were associated with higher utilization rates, indicating the potential contribution of NR3C1 polymorphisms to acute pain heterogeneity in sickle cell disease.",
keywords = "glucocorticoid receptor, NR3C1, pain, polymorphism, sickle cell crisis, sickle cell disease, SNP, utilizations",
author = "Jhun, {Ellie H.} and Nilanjana Sadhu and Yingwei Yao and Ying He and Molokie, {Robert E.} and Wilkie, {Diana J.} and Wang, {Zaijie Jim}",
note = "Funding Information: The study was supported in part by funds from the Illinois Department of Public Health (IDPH) and grants HL078536, HL140031 and HL124945 from the National Heart, Lung, and Blood Institute (NHLBI), NIH. E Jhun was supported by a predoctoral fellowship from NIDCR (DE018381). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the IDPH, NIH, NHLBI, NIDCR or Veteran{\textquoteright}s Administration. The final peer-reviewed manuscript is subject to the NIH Public Access Policy. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of thismanuscript. Publisher Copyright: {\textcopyright} 2018 Future Medicine Ltd.",
year = "2018",
doi = "10.2217/pgs-2018-0064",
language = "English",
volume = "19",
pages = "1003--1011",
journal = "Pharmacogenomics",
issn = "1462-2416",
publisher = "Future Medicine Ltd.",
number = "13",
}