Genetic relationships among multidrug-resistant salmonella enterica serovar typhimurium strains from humans and animals

Yu Ping Hong, You Wun Wang, I. Hsiu Huang, Yu Chieh Liao, Hung Chih Kuo, Yen Yi Liu, Yueh Hua Tu, Bo Han Chen, Ying Shu Liao, Chien Shun Chiou

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

We identified 20 to 22 resistance genes, carried in four incompatibility groups of plasmids, in each of five genetically closely related Salmonella enterica serovar Typhimurium strains recovered from humans, pigs, and chickens. The genes conferred resistance to aminoglycosides, chloramphenicol, sulfonamides, trimethoprim, tetracycline, fluoroquinolones, extended-spectrum cephalosporins and cefoxitin, and azithromycin. This study demonstrates the transmission of multidrug-resistant Salmonella strains among humans and food animals and may be the first identification of mphA in azithromycin-resistant Salmonella strains in Taiwan.

Original languageEnglish
Article numbere00213
JournalAntimicrobial Agents and Chemotherapy
Volume62
Issue number5
DOIs
StatePublished - May 2018
Externally publishedYes

    Fingerprint

Keywords

  • Antimicrobial resistance
  • Mechanisms of resistance
  • Plasmids
  • Salmonella
  • Salmonella enterica serovar Typhimurium
  • Whole-genome sequencing

Cite this

Hong, Y. P., Wang, Y. W., Huang, I. H., Liao, Y. C., Kuo, H. C., Liu, Y. Y., Tu, Y. H., Chen, B. H., Liao, Y. S., & Chiou, C. S. (2018). Genetic relationships among multidrug-resistant salmonella enterica serovar typhimurium strains from humans and animals. Antimicrobial Agents and Chemotherapy, 62(5), [e00213]. https://doi.org/10.1128/AAC.00213-18