Genetic relationships among multidrug-resistant salmonella enterica serovar typhimurium strains from humans and animals

Yu Ping Hong; You Wun Wang; I. Hsiu Huang; Yu Chieh Liao; Hung Chih Kuo; Yen Yi Liu; Yueh Hua Tu; Bo Han Chen; Ying Shu Liao; Chien Shun Chiou

doi:10.1128/AAC.00213-18

Genetic relationships among multidrug-resistant salmonella enterica serovar typhimurium strains from humans and animals

Yu Ping Hong, You Wun Wang, I. Hsiu Huang, Yu Chieh Liao, Hung Chih Kuo, Yen Yi Liu, Yueh Hua Tu, Bo Han Chen, Ying Shu Liao, Chien Shun Chiou

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

We identified 20 to 22 resistance genes, carried in four incompatibility groups of plasmids, in each of five genetically closely related Salmonella enterica serovar Typhimurium strains recovered from humans, pigs, and chickens. The genes conferred resistance to aminoglycosides, chloramphenicol, sulfonamides, trimethoprim, tetracycline, fluoroquinolones, extended-spectrum cephalosporins and cefoxitin, and azithromycin. This study demonstrates the transmission of multidrug-resistant Salmonella strains among humans and food animals and may be the first identification of mphA in azithromycin-resistant Salmonella strains in Taiwan.

Original language	English
Article number	e00213
Journal	Antimicrobial Agents and Chemotherapy
Volume	62
Issue number	5
DOIs	https://doi.org/10.1128/AAC.00213-18
State	Published - May 2018
Externally published	Yes

Keywords

Antimicrobial resistance
Mechanisms of resistance
Plasmids
Salmonella
Salmonella enterica serovar Typhimurium
Whole-genome sequencing

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10.1128/AAC.00213-18

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title = "Genetic relationships among multidrug-resistant salmonella enterica serovar typhimurium strains from humans and animals",

abstract = "We identified 20 to 22 resistance genes, carried in four incompatibility groups of plasmids, in each of five genetically closely related Salmonella enterica serovar Typhimurium strains recovered from humans, pigs, and chickens. The genes conferred resistance to aminoglycosides, chloramphenicol, sulfonamides, trimethoprim, tetracycline, fluoroquinolones, extended-spectrum cephalosporins and cefoxitin, and azithromycin. This study demonstrates the transmission of multidrug-resistant Salmonella strains among humans and food animals and may be the first identification of mphA in azithromycin-resistant Salmonella strains in Taiwan.",

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AU - Hong, Yu Ping

AU - Wang, You Wun

AU - Huang, I. Hsiu

AU - Liao, Yu Chieh

AU - Kuo, Hung Chih

AU - Liu, Yen Yi

AU - Tu, Yueh Hua

AU - Chen, Bo Han

AU - Liao, Ying Shu

AU - Chiou, Chien Shun

PY - 2018/5

Y1 - 2018/5

N2 - We identified 20 to 22 resistance genes, carried in four incompatibility groups of plasmids, in each of five genetically closely related Salmonella enterica serovar Typhimurium strains recovered from humans, pigs, and chickens. The genes conferred resistance to aminoglycosides, chloramphenicol, sulfonamides, trimethoprim, tetracycline, fluoroquinolones, extended-spectrum cephalosporins and cefoxitin, and azithromycin. This study demonstrates the transmission of multidrug-resistant Salmonella strains among humans and food animals and may be the first identification of mphA in azithromycin-resistant Salmonella strains in Taiwan.

AB - We identified 20 to 22 resistance genes, carried in four incompatibility groups of plasmids, in each of five genetically closely related Salmonella enterica serovar Typhimurium strains recovered from humans, pigs, and chickens. The genes conferred resistance to aminoglycosides, chloramphenicol, sulfonamides, trimethoprim, tetracycline, fluoroquinolones, extended-spectrum cephalosporins and cefoxitin, and azithromycin. This study demonstrates the transmission of multidrug-resistant Salmonella strains among humans and food animals and may be the first identification of mphA in azithromycin-resistant Salmonella strains in Taiwan.

KW - Antimicrobial resistance

KW - Mechanisms of resistance

KW - Plasmids

KW - Salmonella

KW - Salmonella enterica serovar Typhimurium

KW - Whole-genome sequencing

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ER -

Genetic relationships among multidrug-resistant salmonella enterica serovar typhimurium strains from humans and animals

Abstract

Keywords

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