Fos expression in non-catecholaminergic neurons in medullary and pontine nuclei after volume depletion induced by polyethylene glycol

Kathleen S. Curtis, Eric G. Krause, Robert J. Contreras

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Fos immunocytochemistry was combined with immunolabeling for dopamine-β-hydroxylase (DBH) to examine neuronal activation in the medulla and pons after administration of polyethelene glycol (PEG), which produces volume depletion without altering arterial blood pressure. Increased Fos immunoreactivity was observed in the area postrema, nucleus of the solitary tract, rostral ventrolateral medulla, lateral parabrachial nucleus, and the dorsomedial pons at the level of the locus coeruleus. Fos immunolabeling in the caudal nucleus of the solitary tract, rostral ventrolateral medulla, and the dorsomedial pons occurred primarily in neurons that did not contain DBH. Thus, PEG activates non-catecholaminergic neurons in medullary and pontine areas associated with cardiovascular and body fluid regulation.

Original languageEnglish
Pages (from-to)149-154
Number of pages6
JournalBrain Research
Volume948
Issue number1-2
DOIs
StatePublished - 6 Sep 2002

Keywords

  • Area postrema
  • Caudal ventrolateral medulla
  • Lateral parabrachial nucleus
  • Locus coeruleus
  • Nucleus tractus solitarius
  • Rostral ventrolateral medulla

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