Fos expression in non-catecholaminergic neurons in medullary and pontine nuclei after volume depletion induced by polyethylene glycol

Kathleen Curtis, Eric G. Krause, Robert J. Contreras

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Fos immunocytochemistry was combined with immunolabeling for dopamine-β-hydroxylase (DBH) to examine neuronal activation in the medulla and pons after administration of polyethelene glycol (PEG), which produces volume depletion without altering arterial blood pressure. Increased Fos immunoreactivity was observed in the area postrema, nucleus of the solitary tract, rostral ventrolateral medulla, lateral parabrachial nucleus, and the dorsomedial pons at the level of the locus coeruleus. Fos immunolabeling in the caudal nucleus of the solitary tract, rostral ventrolateral medulla, and the dorsomedial pons occurred primarily in neurons that did not contain DBH. Thus, PEG activates non-catecholaminergic neurons in medullary and pontine areas associated with cardiovascular and body fluid regulation.

Original languageEnglish
Pages (from-to)149-154
Number of pages6
JournalBrain Research
Volume948
Issue number1-2
DOIs
StatePublished - 6 Sep 2002

Fingerprint

Pons
Glycols
Solitary Nucleus
Neurons
Area Postrema
Locus Coeruleus
Body Fluids
Mixed Function Oxygenases
Dopamine
Arterial Pressure
Immunohistochemistry

Keywords

  • Area postrema
  • Caudal ventrolateral medulla
  • Lateral parabrachial nucleus
  • Locus coeruleus
  • Nucleus tractus solitarius
  • Rostral ventrolateral medulla

Cite this

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abstract = "Fos immunocytochemistry was combined with immunolabeling for dopamine-β-hydroxylase (DBH) to examine neuronal activation in the medulla and pons after administration of polyethelene glycol (PEG), which produces volume depletion without altering arterial blood pressure. Increased Fos immunoreactivity was observed in the area postrema, nucleus of the solitary tract, rostral ventrolateral medulla, lateral parabrachial nucleus, and the dorsomedial pons at the level of the locus coeruleus. Fos immunolabeling in the caudal nucleus of the solitary tract, rostral ventrolateral medulla, and the dorsomedial pons occurred primarily in neurons that did not contain DBH. Thus, PEG activates non-catecholaminergic neurons in medullary and pontine areas associated with cardiovascular and body fluid regulation.",
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Fos expression in non-catecholaminergic neurons in medullary and pontine nuclei after volume depletion induced by polyethylene glycol. / Curtis, Kathleen; Krause, Eric G.; Contreras, Robert J.

In: Brain Research, Vol. 948, No. 1-2, 06.09.2002, p. 149-154.

Research output: Contribution to journalArticle

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AU - Krause, Eric G.

AU - Contreras, Robert J.

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