Folding RNA with the minimal loss of entropy

Ariel Fernández, Hugo Arias, Diego Guerín

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The principle of sequential minimization of entropy loss (SMEL) is introduced and justified within the context of biopolymer folding in vitro. This principle implies that at each stage in the dominant folding pathway, the conformational entropy loss associated with loop closure, ΔSloop, is minimized while the number of effective contacts is maximized. The applicability of the SMEL principle is contingent upon a rigorous and reliable derivation of the contribution ΔSloop. This derivation is carried out in this work for RNA by taking into account the orientational restrictions associated with the self-energy of charged phosphate moieties within a loop. The predictive potential of the principle is revealed by showing that the theory reproduces the biologically competent secondary structures of specific catalytically competent RNA's.

Original languageEnglish
JournalPhysical Review E
Volume52
Issue number2
DOIs
StatePublished - 1 Jan 1995
Externally publishedYes

Fingerprint

Entropy Loss
Folding
folding
Entropy
entropy
Biopolymers
derivation
Secondary Structure
Phosphate
optimization
biopolymers
Pathway
Closure
Contact
closures
Restriction
Imply
constrictions
phosphates
Energy

Cite this

Fernández, Ariel ; Arias, Hugo ; Guerín, Diego. / Folding RNA with the minimal loss of entropy. In: Physical Review E. 1995 ; Vol. 52, No. 2.
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Folding RNA with the minimal loss of entropy. / Fernández, Ariel; Arias, Hugo; Guerín, Diego.

In: Physical Review E, Vol. 52, No. 2, 01.01.1995.

Research output: Contribution to journalArticle

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