Fibronexus in a case of malignant fibrous histiocytoma

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    A 78-year-old man presented with a subcutaneous supraorbital tumor measuring approximately 4.0 × 3.0 × 1.8 cm. It was removed in several irregular portions, and histologic sections were taken from each portion. The lesion was diagnosed as a grade 3 malignant fibrous histiocytoma. Further characterization of the tumor necessitated the use of transmission electron microscopy. This appears to be the first report of fibronexus in malignant fibrous histiocytoma. This structure linked the myofibroblast with the extracellular matrix; specifically, microfilaments were linked to fibronectin fibrils. Interaction between collagen and fibronectin was noted within the extracellular matrix.

    Original languageEnglish
    Pages (from-to)365-370
    Number of pages6
    JournalUltrastructural Pathology
    Volume18
    Issue number3
    DOIs
    StatePublished - 1 Jan 1994

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    Malignant Fibrous Histiocytoma
    Fibronectins
    Extracellular Matrix
    Tumors
    tumors
    Myofibroblasts
    collagens
    matrices
    Transmission Electron Microscopy
    Actin Cytoskeleton
    Collagen
    lesions
    grade
    Neoplasms
    Transmission electron microscopy
    transmission electron microscopy
    interactions

    Keywords

    • Electron microscopy
    • Fibronexus
    • MFH
    • Microfilaments
    • Myofibroblast

    Cite this

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    title = "Fibronexus in a case of malignant fibrous histiocytoma",
    abstract = "A 78-year-old man presented with a subcutaneous supraorbital tumor measuring approximately 4.0 × 3.0 × 1.8 cm. It was removed in several irregular portions, and histologic sections were taken from each portion. The lesion was diagnosed as a grade 3 malignant fibrous histiocytoma. Further characterization of the tumor necessitated the use of transmission electron microscopy. This appears to be the first report of fibronexus in malignant fibrous histiocytoma. This structure linked the myofibroblast with the extracellular matrix; specifically, microfilaments were linked to fibronectin fibrils. Interaction between collagen and fibronectin was noted within the extracellular matrix.",
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    Fibronexus in a case of malignant fibrous histiocytoma. / Meek, William D.

    In: Ultrastructural Pathology, Vol. 18, No. 3, 01.01.1994, p. 365-370.

    Research output: Contribution to journalArticle

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