Evolution of microbial pathogens

Joachim Morschhäuser, Gerwald Koehler, Wilma Ziebuhr, Gabriele Blum-Oehler, Ulrich Dobrindt, Jörg Hacker

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Various genetic mechanisms including point mutations, genetic rearrangements and lateral gene transfer processes contribute to the evolution of microbes. Long-term processes leading to the development of new species or subspecies are termed macroevolution, and short-term developments, which occur during days or weeks, are considered as microevolution. Both processes, macro- and microevolution need horizontal gene transfer, which is particularly important for the development of pathogenic microorganisms. Plasmids, bacteriophages and so-called pathogenicity islands (PAIs) play a crucial role in the evolution of pathogens. During microevolution, genome variability of pathogenic microbes leads to new phenotypes, which play an important role in the acute development of an infectious disease. Infections due to Staphylococcus epidermidis, Candida albicans and Escherichia coli will be described with special emphasis on processes of microevolution. In contrast, the development of PAIs is a process involved in macroevolution. PAIs are especially important in processes leading to new pathotypes or even species. In this review, particular attention will be given to the fact that the evolution of pathogenic microbes can be considered as a specific example for microbial evolution in general.

Original languageEnglish
Pages (from-to)695-704
Number of pages10
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume355
Issue number1397
DOIs
StatePublished - 29 May 2000

Fingerprint

Genomic Islands
Pathogens
pathogenicity islands
Gene transfer
Horizontal Gene Transfer
microorganisms
pathogens
Bacteriophages
Staphylococcus epidermidis
Candida
Candida albicans
Point Mutation
Microorganisms
Escherichia coli
Communicable Diseases
Macros
new subspecies
pathotypes
Plasmids
point mutation

Keywords

  • Biofilm
  • Codon usage
  • Evolution
  • Genomic island
  • Pathogenicity
  • Resistance

Cite this

Morschhäuser, J., Koehler, G., Ziebuhr, W., Blum-Oehler, G., Dobrindt, U., & Hacker, J. (2000). Evolution of microbial pathogens. Philosophical Transactions of the Royal Society B: Biological Sciences, 355(1397), 695-704. https://doi.org/10.1098/rstb.2000.0609
Morschhäuser, Joachim ; Koehler, Gerwald ; Ziebuhr, Wilma ; Blum-Oehler, Gabriele ; Dobrindt, Ulrich ; Hacker, Jörg. / Evolution of microbial pathogens. In: Philosophical Transactions of the Royal Society B: Biological Sciences. 2000 ; Vol. 355, No. 1397. pp. 695-704.
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Morschhäuser, J, Koehler, G, Ziebuhr, W, Blum-Oehler, G, Dobrindt, U & Hacker, J 2000, 'Evolution of microbial pathogens', Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 355, no. 1397, pp. 695-704. https://doi.org/10.1098/rstb.2000.0609

Evolution of microbial pathogens. / Morschhäuser, Joachim; Koehler, Gerwald; Ziebuhr, Wilma; Blum-Oehler, Gabriele; Dobrindt, Ulrich; Hacker, Jörg.

In: Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 355, No. 1397, 29.05.2000, p. 695-704.

Research output: Contribution to journalArticle

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