TY - JOUR
T1 - Evidence for a large-scale brain system supporting allostasis and interoception in humans
AU - Kleckner, Ian R.
AU - Zhang, Jiahe
AU - Touroutoglou, Alexandra
AU - Chanes, Lorena
AU - Xia, Chenjie
AU - Simmons, W. Kyle
AU - Quigley, Karen S.
AU - Dickerson, Bradford C.
AU - Feldman Barrett, Lisa
N1 - Publisher Copyright:
© 2017 Macmillan Publishers Limited, part of Spr nger Nature.
PY - 2017/4/10
Y1 - 2017/4/10
N2 - Large-scale intrinsic brain systems have been identified for exteroceptive senses (such as sight, hearing and touch). We introduce an analogous system for representing sensations from within the body, called interoception, and demonstrate its relation to regulating peripheral systems in the body, called allostasis. Employing the recently introduced Embodied Predictive Interoception Coding (EPIC) model, we used tract-tracing studies of macaque monkeys, followed by two intrinsic functional magnetic resonance imaging samples (N = 280 and N = 270) to evaluate the existence of an intrinsic allostatic-interoceptive system in the human brain. Another sample (N = 41) allowed us to evaluate the convergent validity of the hypothesized allostatic-interoceptive system by showing that individuals with stronger connectivity between system hubs performed better on an implicit index of interoceptive ability related to autonomic fluctuations. Implications include insights for the brain's functional architecture, dissolving the artificial boundary between mind and body, and unifying mental and physical illness.
AB - Large-scale intrinsic brain systems have been identified for exteroceptive senses (such as sight, hearing and touch). We introduce an analogous system for representing sensations from within the body, called interoception, and demonstrate its relation to regulating peripheral systems in the body, called allostasis. Employing the recently introduced Embodied Predictive Interoception Coding (EPIC) model, we used tract-tracing studies of macaque monkeys, followed by two intrinsic functional magnetic resonance imaging samples (N = 280 and N = 270) to evaluate the existence of an intrinsic allostatic-interoceptive system in the human brain. Another sample (N = 41) allowed us to evaluate the convergent validity of the hypothesized allostatic-interoceptive system by showing that individuals with stronger connectivity between system hubs performed better on an implicit index of interoceptive ability related to autonomic fluctuations. Implications include insights for the brain's functional architecture, dissolving the artificial boundary between mind and body, and unifying mental and physical illness.
UR - http://www.scopus.com/inward/record.url?scp=85018424307&partnerID=8YFLogxK
U2 - 10.1038/s41562-017-0069
DO - 10.1038/s41562-017-0069
M3 - Review article
AN - SCOPUS:85018424307
SN - 2397-3374
VL - 1
JO - Nature Human Behaviour
JF - Nature Human Behaviour
IS - 5
M1 - 0069
ER -