Estradiol and osmolality: Behavioral responses and central pathways

Kathleen S. Curtis

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Regulation of appropriate osmolality of body fluid is critical for survival, yet there are sex differences in compensatory responses to osmotic challenges. Few studies have focused on the role of sex hormones such as estradiol in behavioral responses to increases or decreases in systemic osmolality, and even fewer studies have investigated whether central actions of estrogens contribute to these responses. This overview integrates findings from a series of ongoing and completed experiments conducted in my laboratory to assess estradiol effects on water and NaCl intake in response to osmotic challenges, and on activity in central pathways that mediate such responses.

Original languageEnglish
Pages (from-to)422-430
Number of pages9
JournalPhysiology and Behavior
StatePublished - 1 Dec 2015


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