Erythropoiesis in women during 11 days at 4,300 m is not affected by menstrual cycle phase

John T. Reeves, Stacy Zamudio, Thomas E. Dahms, Ingrid Asmus, Barry Braun, Gail E. Butterfield, Rosann G. McCullough, Stephen R. Muza, Paul B. Rock, Lorna G. Moore

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Abstract

Because the ovarian steroid hormones, progesterone and estrogen, have higher blood levels in the luteal (L) than in the follicular (F) phase of the menstrual cycle, and because of their known effects on ventilation and hematopoiesis, we hypothesized that less hypoxemia and less erythropoiesis would occur in the L than the F phase of the cycle after arrival at altitude. We examined erythropoiesis with menstrual cycle phase in 16 women (age 22.6 ± 0.6 yr). At sea level, 11 of 16 women were studied during both menstrual cycle phases, and, where comparison within women was available, cycle phase did not alter erythropoietin (n = 5), reticulocyte count (n = 10), and red cell volume (n = 9). When all 16 women were taken for 11 days to 4,300-m altitude (barometric pressure = 462 mmHg), paired comparisons within women showed no differences in ovarian hormone concentrations at sea level vs. altitude on menstrual cycle day 3 or 10 for either the F (n = 11) or the L (n = 5) phase groups. Arterial oxygen saturation did not differ between the F and L groups at altitude. There were no differences by cycle phase on day 11 at 4,300 m for erythropoietin [22.9 ± 4.7 (L) vs. 18.8 ± 3.4 mU/ml (F)], percent reticulocytes [1.9 ± 0.1 (L) vs. 2.1 ± 0.3% (F)], hemoglobin [13.5 ± 0.3 (L) vs. 13.7 ± 0.3 g/100 ml (F)], percent hematocrit [40.6 ± 1.4 (L) vs. 40.7 ± 1.0% (F)], red cell volume [31.1 ± 3.6 (L) vs. 33.0 ± 1.6 ml/kg (F)], and blood ferritin [8.9 ± 1.7 (L) vs. 10.2 ± 0.9 μg/l (F)]. Blood level of erythropoietin was related (r = 0.77) to arterial oxygen saturation but not to the levels of progesterone or estradiol. We conclude that erythropoiesis was not altered by menstrual cycle phase during the first days at 4,300-m altitude.

Original languageEnglish
Pages (from-to)2579-2586
Number of pages8
JournalJournal of Applied Physiology
Volume91
Issue number6
StatePublished - 13 Dec 2001

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Erythropoiesis
Menstrual Cycle
Erythropoietin
Cell Size
Oceans and Seas
Progesterone
Hormones
Oxygen
Reticulocyte Count
Matched-Pair Analysis
Fetal Hemoglobin
Follicular Phase
Reticulocytes
Corpus Luteum
Hematopoiesis
Ferritins
Hematocrit
Ventilation
Estradiol
Estrogens

Keywords

  • Erythropoietin
  • Ferritin
  • Red cell volume
  • Reticulocytes

Cite this

Reeves, J. T., Zamudio, S., Dahms, T. E., Asmus, I., Braun, B., Butterfield, G. E., ... Moore, L. G. (2001). Erythropoiesis in women during 11 days at 4,300 m is not affected by menstrual cycle phase. Journal of Applied Physiology, 91(6), 2579-2586.
Reeves, John T. ; Zamudio, Stacy ; Dahms, Thomas E. ; Asmus, Ingrid ; Braun, Barry ; Butterfield, Gail E. ; McCullough, Rosann G. ; Muza, Stephen R. ; Rock, Paul B. ; Moore, Lorna G. / Erythropoiesis in women during 11 days at 4,300 m is not affected by menstrual cycle phase. In: Journal of Applied Physiology. 2001 ; Vol. 91, No. 6. pp. 2579-2586.
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abstract = "Because the ovarian steroid hormones, progesterone and estrogen, have higher blood levels in the luteal (L) than in the follicular (F) phase of the menstrual cycle, and because of their known effects on ventilation and hematopoiesis, we hypothesized that less hypoxemia and less erythropoiesis would occur in the L than the F phase of the cycle after arrival at altitude. We examined erythropoiesis with menstrual cycle phase in 16 women (age 22.6 ± 0.6 yr). At sea level, 11 of 16 women were studied during both menstrual cycle phases, and, where comparison within women was available, cycle phase did not alter erythropoietin (n = 5), reticulocyte count (n = 10), and red cell volume (n = 9). When all 16 women were taken for 11 days to 4,300-m altitude (barometric pressure = 462 mmHg), paired comparisons within women showed no differences in ovarian hormone concentrations at sea level vs. altitude on menstrual cycle day 3 or 10 for either the F (n = 11) or the L (n = 5) phase groups. Arterial oxygen saturation did not differ between the F and L groups at altitude. There were no differences by cycle phase on day 11 at 4,300 m for erythropoietin [22.9 ± 4.7 (L) vs. 18.8 ± 3.4 mU/ml (F)], percent reticulocytes [1.9 ± 0.1 (L) vs. 2.1 ± 0.3{\%} (F)], hemoglobin [13.5 ± 0.3 (L) vs. 13.7 ± 0.3 g/100 ml (F)], percent hematocrit [40.6 ± 1.4 (L) vs. 40.7 ± 1.0{\%} (F)], red cell volume [31.1 ± 3.6 (L) vs. 33.0 ± 1.6 ml/kg (F)], and blood ferritin [8.9 ± 1.7 (L) vs. 10.2 ± 0.9 μg/l (F)]. Blood level of erythropoietin was related (r = 0.77) to arterial oxygen saturation but not to the levels of progesterone or estradiol. We conclude that erythropoiesis was not altered by menstrual cycle phase during the first days at 4,300-m altitude.",
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Reeves, JT, Zamudio, S, Dahms, TE, Asmus, I, Braun, B, Butterfield, GE, McCullough, RG, Muza, SR, Rock, PB & Moore, LG 2001, 'Erythropoiesis in women during 11 days at 4,300 m is not affected by menstrual cycle phase', Journal of Applied Physiology, vol. 91, no. 6, pp. 2579-2586.

Erythropoiesis in women during 11 days at 4,300 m is not affected by menstrual cycle phase. / Reeves, John T.; Zamudio, Stacy; Dahms, Thomas E.; Asmus, Ingrid; Braun, Barry; Butterfield, Gail E.; McCullough, Rosann G.; Muza, Stephen R.; Rock, Paul B.; Moore, Lorna G.

In: Journal of Applied Physiology, Vol. 91, No. 6, 13.12.2001, p. 2579-2586.

Research output: Contribution to journalArticle

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T1 - Erythropoiesis in women during 11 days at 4,300 m is not affected by menstrual cycle phase

AU - Reeves, John T.

AU - Zamudio, Stacy

AU - Dahms, Thomas E.

AU - Asmus, Ingrid

AU - Braun, Barry

AU - Butterfield, Gail E.

AU - McCullough, Rosann G.

AU - Muza, Stephen R.

AU - Rock, Paul B.

AU - Moore, Lorna G.

PY - 2001/12/13

Y1 - 2001/12/13

N2 - Because the ovarian steroid hormones, progesterone and estrogen, have higher blood levels in the luteal (L) than in the follicular (F) phase of the menstrual cycle, and because of their known effects on ventilation and hematopoiesis, we hypothesized that less hypoxemia and less erythropoiesis would occur in the L than the F phase of the cycle after arrival at altitude. We examined erythropoiesis with menstrual cycle phase in 16 women (age 22.6 ± 0.6 yr). At sea level, 11 of 16 women were studied during both menstrual cycle phases, and, where comparison within women was available, cycle phase did not alter erythropoietin (n = 5), reticulocyte count (n = 10), and red cell volume (n = 9). When all 16 women were taken for 11 days to 4,300-m altitude (barometric pressure = 462 mmHg), paired comparisons within women showed no differences in ovarian hormone concentrations at sea level vs. altitude on menstrual cycle day 3 or 10 for either the F (n = 11) or the L (n = 5) phase groups. Arterial oxygen saturation did not differ between the F and L groups at altitude. There were no differences by cycle phase on day 11 at 4,300 m for erythropoietin [22.9 ± 4.7 (L) vs. 18.8 ± 3.4 mU/ml (F)], percent reticulocytes [1.9 ± 0.1 (L) vs. 2.1 ± 0.3% (F)], hemoglobin [13.5 ± 0.3 (L) vs. 13.7 ± 0.3 g/100 ml (F)], percent hematocrit [40.6 ± 1.4 (L) vs. 40.7 ± 1.0% (F)], red cell volume [31.1 ± 3.6 (L) vs. 33.0 ± 1.6 ml/kg (F)], and blood ferritin [8.9 ± 1.7 (L) vs. 10.2 ± 0.9 μg/l (F)]. Blood level of erythropoietin was related (r = 0.77) to arterial oxygen saturation but not to the levels of progesterone or estradiol. We conclude that erythropoiesis was not altered by menstrual cycle phase during the first days at 4,300-m altitude.

AB - Because the ovarian steroid hormones, progesterone and estrogen, have higher blood levels in the luteal (L) than in the follicular (F) phase of the menstrual cycle, and because of their known effects on ventilation and hematopoiesis, we hypothesized that less hypoxemia and less erythropoiesis would occur in the L than the F phase of the cycle after arrival at altitude. We examined erythropoiesis with menstrual cycle phase in 16 women (age 22.6 ± 0.6 yr). At sea level, 11 of 16 women were studied during both menstrual cycle phases, and, where comparison within women was available, cycle phase did not alter erythropoietin (n = 5), reticulocyte count (n = 10), and red cell volume (n = 9). When all 16 women were taken for 11 days to 4,300-m altitude (barometric pressure = 462 mmHg), paired comparisons within women showed no differences in ovarian hormone concentrations at sea level vs. altitude on menstrual cycle day 3 or 10 for either the F (n = 11) or the L (n = 5) phase groups. Arterial oxygen saturation did not differ between the F and L groups at altitude. There were no differences by cycle phase on day 11 at 4,300 m for erythropoietin [22.9 ± 4.7 (L) vs. 18.8 ± 3.4 mU/ml (F)], percent reticulocytes [1.9 ± 0.1 (L) vs. 2.1 ± 0.3% (F)], hemoglobin [13.5 ± 0.3 (L) vs. 13.7 ± 0.3 g/100 ml (F)], percent hematocrit [40.6 ± 1.4 (L) vs. 40.7 ± 1.0% (F)], red cell volume [31.1 ± 3.6 (L) vs. 33.0 ± 1.6 ml/kg (F)], and blood ferritin [8.9 ± 1.7 (L) vs. 10.2 ± 0.9 μg/l (F)]. Blood level of erythropoietin was related (r = 0.77) to arterial oxygen saturation but not to the levels of progesterone or estradiol. We conclude that erythropoiesis was not altered by menstrual cycle phase during the first days at 4,300-m altitude.

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Reeves JT, Zamudio S, Dahms TE, Asmus I, Braun B, Butterfield GE et al. Erythropoiesis in women during 11 days at 4,300 m is not affected by menstrual cycle phase. Journal of Applied Physiology. 2001 Dec 13;91(6):2579-2586.