TY - JOUR
T1 - Erratum
T2 - Behavioral activation therapy for depression is associated with a reduction in the concentration of circulating quinolinic acid (Psychological Medicine (2020) (1–10) DOI: 10.1017/S0033291720004389)
AU - Savitz, Jonathan
AU - Ford, Bart N.
AU - Yeh, Hung Wen
AU - Akeman, Elisabeth
AU - Cosgrove, Kelly
AU - Clausen, Ashley N.
AU - Martell, Christopher
AU - Kirlic, Namik
AU - Santiago, Jessica
AU - Teague, T. Kent
AU - Irwin, Michael R.
AU - Paulus, Martin P.
AU - Aupperle, Robin L.
N1 - Publisher Copyright:
© 2021 Cambridge University Press. All rights reserved.
PY - 2021
Y1 - 2021
N2 - The authors of the Psychological Medicine article “Behavioral activation therapy for depression is associated with a reduction in the concentration of circulating quinolinic acid” (Savitz et al., 2020) have identified an error in one of the analyses and associated results reported. The error specifically related to Hypothesis 3, that the magnitude of change in blood biomarkers from pre- to post-therapy would be associated with improvements in depressive symptoms. The original manuscript reports that the increase in the kynurenic acid (KynA) to quinolinic acid (QuinA) was associated with the decrease in PROMIS-Depression scores (F11,218 = 1.7, p = 0.074, Cohen’s f2 = 0.054), and that the decrease in IL-1RA was marginally associated with the decrease in PROMIS-Depression scores (F11,218 = 1.8, uncorrected p = 0.057, Cohen’s f2 = 0.082) but did not survive FDR correction. An error was found in the code that calculated the percent change in the biomarkers from pre- to post-therapy (using the post-treatment values as the denominator rather than the pre-treatment values). Correcting this calculation results in minor changes to the values for percent change and once corrected, the association between the change in KynA/QuinA and PROMIS-Depression scores was no longer significant (F11,218 = 0.9, p = 0.504, Cohen’s f2 = 0.034), and the association between the change in IL-1RA and PROMIS-Depression scores was strengthened (F11,218 = 2.6, uncorrected p = 0.004, Cohen’s f2 = 0.084) but still did not survive FDR correction (Benjamini-Hochberg adjusted p = 0.141). This correction does not affect any of the other results reported in this study, nor does it alter our overall interpretation of the results.
AB - The authors of the Psychological Medicine article “Behavioral activation therapy for depression is associated with a reduction in the concentration of circulating quinolinic acid” (Savitz et al., 2020) have identified an error in one of the analyses and associated results reported. The error specifically related to Hypothesis 3, that the magnitude of change in blood biomarkers from pre- to post-therapy would be associated with improvements in depressive symptoms. The original manuscript reports that the increase in the kynurenic acid (KynA) to quinolinic acid (QuinA) was associated with the decrease in PROMIS-Depression scores (F11,218 = 1.7, p = 0.074, Cohen’s f2 = 0.054), and that the decrease in IL-1RA was marginally associated with the decrease in PROMIS-Depression scores (F11,218 = 1.8, uncorrected p = 0.057, Cohen’s f2 = 0.082) but did not survive FDR correction. An error was found in the code that calculated the percent change in the biomarkers from pre- to post-therapy (using the post-treatment values as the denominator rather than the pre-treatment values). Correcting this calculation results in minor changes to the values for percent change and once corrected, the association between the change in KynA/QuinA and PROMIS-Depression scores was no longer significant (F11,218 = 0.9, p = 0.504, Cohen’s f2 = 0.034), and the association between the change in IL-1RA and PROMIS-Depression scores was strengthened (F11,218 = 2.6, uncorrected p = 0.004, Cohen’s f2 = 0.084) but still did not survive FDR correction (Benjamini-Hochberg adjusted p = 0.141). This correction does not affect any of the other results reported in this study, nor does it alter our overall interpretation of the results.
UR - http://www.scopus.com/inward/record.url?scp=85110457511&partnerID=8YFLogxK
U2 - 10.1017/S0033291721002683
DO - 10.1017/S0033291721002683
M3 - Comment/debate
AN - SCOPUS:85110457511
SN - 0033-2917
VL - 52
SP - 2846
JO - Psychological Medicine
JF - Psychological Medicine
IS - 13
ER -