Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies

Vladimir R. Djordjevic, David Wallace, Amie Schweitzer, Novica Boricic, Djordje Knezevic, Slavko Matic, Nikola Grubor, Mirko Kerkez, Dejan Radenkovic, Zorica Bulat, Biljana Antonijevic, Vesna Matovic, Aleksandra Buha

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Although profoundly studied, etiology of pancreatic cancer (PC)is still rather scarce. Some of established risk factors of PC are connected to an increased cadmium (Cd)body burden. Hence, the aim of this study was to investigate the role of this environmental pollutant in PC development by conducting human observational, experimental and in vitro studies. The case-control study included 31 patients with a histologically based diagnosis of exocrine PC subjected to radical surgical intervention as cases and 29 accidental fatalities or subjects who died of a nonmalignant illness as controls. Animal study included two treated groups of Wistar rats (15 and 30 mg Cd/kg b.w)and untreated control group, sacrificed 24 h after single oral exposure. In in vitro study pancreas hTERT-HPNE and AsPC-1 cells were exposed to different Cd concentrations corresponding to levels measured in human cancerous pancreatic tissue. Cd content in cancer tissue significantly differed from the content in healthy controls. Odds ratio levels for PC development were 2.79 (95% CI 0.91–8.50)and 3.44 (95% CI 1.19–9.95)in the third and fourth quartiles of Cd distribution, respectively. Animal study confirmed Cd deposition in pancreatic tissue. In vitro studies revealed that Cd produces disturbances in intrinsic pathway of apoptotic activity and the elevation in oxidative stress in pancreatic cells. This study presents three different lines of evidence pointing towards Cd as an agent responsible for the development of PC.

Original languageEnglish
Pages (from-to)353-361
Number of pages9
JournalEnvironment International
Volume128
DOIs
StatePublished - 1 Jul 2019

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cancer
cadmium
animal
exposure
etiology
risk factor
disturbance
pollutant
tissue

Keywords

  • Cadmium
  • Carcinogenesis
  • Pancreatic cancer
  • Risk factors

Cite this

Djordjevic, Vladimir R. ; Wallace, David ; Schweitzer, Amie ; Boricic, Novica ; Knezevic, Djordje ; Matic, Slavko ; Grubor, Nikola ; Kerkez, Mirko ; Radenkovic, Dejan ; Bulat, Zorica ; Antonijevic, Biljana ; Matovic, Vesna ; Buha, Aleksandra. / Environmental cadmium exposure and pancreatic cancer : Evidence from case control, animal and in vitro studies. In: Environment International. 2019 ; Vol. 128. pp. 353-361.
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abstract = "Although profoundly studied, etiology of pancreatic cancer (PC)is still rather scarce. Some of established risk factors of PC are connected to an increased cadmium (Cd)body burden. Hence, the aim of this study was to investigate the role of this environmental pollutant in PC development by conducting human observational, experimental and in vitro studies. The case-control study included 31 patients with a histologically based diagnosis of exocrine PC subjected to radical surgical intervention as cases and 29 accidental fatalities or subjects who died of a nonmalignant illness as controls. Animal study included two treated groups of Wistar rats (15 and 30 mg Cd/kg b.w)and untreated control group, sacrificed 24 h after single oral exposure. In in vitro study pancreas hTERT-HPNE and AsPC-1 cells were exposed to different Cd concentrations corresponding to levels measured in human cancerous pancreatic tissue. Cd content in cancer tissue significantly differed from the content in healthy controls. Odds ratio levels for PC development were 2.79 (95{\%} CI 0.91–8.50)and 3.44 (95{\%} CI 1.19–9.95)in the third and fourth quartiles of Cd distribution, respectively. Animal study confirmed Cd deposition in pancreatic tissue. In vitro studies revealed that Cd produces disturbances in intrinsic pathway of apoptotic activity and the elevation in oxidative stress in pancreatic cells. This study presents three different lines of evidence pointing towards Cd as an agent responsible for the development of PC.",
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Djordjevic, VR, Wallace, D, Schweitzer, A, Boricic, N, Knezevic, D, Matic, S, Grubor, N, Kerkez, M, Radenkovic, D, Bulat, Z, Antonijevic, B, Matovic, V & Buha, A 2019, 'Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies', Environment International, vol. 128, pp. 353-361. https://doi.org/10.1016/j.envint.2019.04.048

Environmental cadmium exposure and pancreatic cancer : Evidence from case control, animal and in vitro studies. / Djordjevic, Vladimir R.; Wallace, David; Schweitzer, Amie; Boricic, Novica; Knezevic, Djordje; Matic, Slavko; Grubor, Nikola; Kerkez, Mirko; Radenkovic, Dejan; Bulat, Zorica; Antonijevic, Biljana; Matovic, Vesna; Buha, Aleksandra.

In: Environment International, Vol. 128, 01.07.2019, p. 353-361.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Environmental cadmium exposure and pancreatic cancer

T2 - Evidence from case control, animal and in vitro studies

AU - Djordjevic, Vladimir R.

AU - Wallace, David

AU - Schweitzer, Amie

AU - Boricic, Novica

AU - Knezevic, Djordje

AU - Matic, Slavko

AU - Grubor, Nikola

AU - Kerkez, Mirko

AU - Radenkovic, Dejan

AU - Bulat, Zorica

AU - Antonijevic, Biljana

AU - Matovic, Vesna

AU - Buha, Aleksandra

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