Elevated plasma vasopressin concentrations during endotoxin and E. coli shock.

M. F. Wilson, D. J. Brackett, P. Tompkins, B. Benjamin, L. T. Archer, L. B. Hinshaw

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Plasma vasopressin concentrations, measured by radioimmunoassay, were remarkably elevated during endotoxin and E. coli shock. The concentrations were often above 500 pg/ml in dogs and above 300 pg/ml in baboons; they reached 1200 pg/ml in two dogs and 1800 pg/ml in another. Plasma concentration in a quiet, hydrated subject is 4 pg/ml; osmoregulation is maximally effective at 20 pg/ml. Elevation of plasma vasopressin occurred by 15 minutes after beginning infusion of endotoxin or E. coli and reached concentrations of 200-350 pg/ml with a decrease in cardiac output but before hypotension, which suggests decreased thoracic blood volume and decompression of left atrial stretch receptors. Even higher vasopressin levels were associated with a reduction of arterial blood pressure. The typical pattern was an early peak elevation followed by a sustained plateau of plasma vasopressin concentration in dogs and baboons with endotoxin and/or E. coli-induced circulatory shock.

Original languageEnglish
Pages (from-to)15-26
Number of pages12
JournalAdvances in shock research
Volume6
StatePublished - 1 Dec 1981

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Vasopressins
Endotoxins
Shock
Escherichia coli
Papio
Dogs
Osmoregulation
Mechanoreceptors
Decompression
Blood Volume
Cardiac Output
Hypotension
Radioimmunoassay
Arterial Pressure
Thorax

Cite this

Wilson, M. F., Brackett, D. J., Tompkins, P., Benjamin, B., Archer, L. T., & Hinshaw, L. B. (1981). Elevated plasma vasopressin concentrations during endotoxin and E. coli shock. Advances in shock research, 6, 15-26.
Wilson, M. F. ; Brackett, D. J. ; Tompkins, P. ; Benjamin, B. ; Archer, L. T. ; Hinshaw, L. B. / Elevated plasma vasopressin concentrations during endotoxin and E. coli shock. In: Advances in shock research. 1981 ; Vol. 6. pp. 15-26.
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Wilson, MF, Brackett, DJ, Tompkins, P, Benjamin, B, Archer, LT & Hinshaw, LB 1981, 'Elevated plasma vasopressin concentrations during endotoxin and E. coli shock.', Advances in shock research, vol. 6, pp. 15-26.

Elevated plasma vasopressin concentrations during endotoxin and E. coli shock. / Wilson, M. F.; Brackett, D. J.; Tompkins, P.; Benjamin, B.; Archer, L. T.; Hinshaw, L. B.

In: Advances in shock research, Vol. 6, 01.12.1981, p. 15-26.

Research output: Contribution to journalArticle

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AU - Brackett, D. J.

AU - Tompkins, P.

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AU - Archer, L. T.

AU - Hinshaw, L. B.

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N2 - Plasma vasopressin concentrations, measured by radioimmunoassay, were remarkably elevated during endotoxin and E. coli shock. The concentrations were often above 500 pg/ml in dogs and above 300 pg/ml in baboons; they reached 1200 pg/ml in two dogs and 1800 pg/ml in another. Plasma concentration in a quiet, hydrated subject is 4 pg/ml; osmoregulation is maximally effective at 20 pg/ml. Elevation of plasma vasopressin occurred by 15 minutes after beginning infusion of endotoxin or E. coli and reached concentrations of 200-350 pg/ml with a decrease in cardiac output but before hypotension, which suggests decreased thoracic blood volume and decompression of left atrial stretch receptors. Even higher vasopressin levels were associated with a reduction of arterial blood pressure. The typical pattern was an early peak elevation followed by a sustained plateau of plasma vasopressin concentration in dogs and baboons with endotoxin and/or E. coli-induced circulatory shock.

AB - Plasma vasopressin concentrations, measured by radioimmunoassay, were remarkably elevated during endotoxin and E. coli shock. The concentrations were often above 500 pg/ml in dogs and above 300 pg/ml in baboons; they reached 1200 pg/ml in two dogs and 1800 pg/ml in another. Plasma concentration in a quiet, hydrated subject is 4 pg/ml; osmoregulation is maximally effective at 20 pg/ml. Elevation of plasma vasopressin occurred by 15 minutes after beginning infusion of endotoxin or E. coli and reached concentrations of 200-350 pg/ml with a decrease in cardiac output but before hypotension, which suggests decreased thoracic blood volume and decompression of left atrial stretch receptors. Even higher vasopressin levels were associated with a reduction of arterial blood pressure. The typical pattern was an early peak elevation followed by a sustained plateau of plasma vasopressin concentration in dogs and baboons with endotoxin and/or E. coli-induced circulatory shock.

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Wilson MF, Brackett DJ, Tompkins P, Benjamin B, Archer LT, Hinshaw LB. Elevated plasma vasopressin concentrations during endotoxin and E. coli shock. Advances in shock research. 1981 Dec 1;6:15-26.