Effects of social defeat on iK-ba inflammatory signaling in male c57BL/6J

Christopher Johnson, Randall Davis, Daniel J. Buck, Kelly McCracken

Research output: Contribution to conferencePoster

Abstract

An estimated 30 million people in the United States have been diagnosed with mood and anxiety disorders. Unfortunately, many of these patients do not adequately respond to current pharmacotherapies, so developing new drugs and strategies to treat such disorders is critically important. There are only a few drugs on the market that target neuroinflammation. Thus, it's critical that we identify anti-inflammatory agents that effectively reduce neuroinflammatory responses, hereby expanding or augmenting available options for treating neurological disorders. Previous work has shown that the derivative of naltrexone, B-funaltrexamine (B-FNA), inhibits inflammatory signaling in human astrocytes in reduced expression of proinflammatory chemokines. IKBa is one of the specific signaling proteins in the inflammation pathway.
Original languageAmerican English
StatePublished - 4 Sep 2020
EventOklahoma State University Center for Health Sciences Research Day 2020 - Oklahoma State University Center for Health Sciences College of Osteopathic Medicine, Tulsa, United States
Duration: 27 Feb 202028 Feb 2020

Conference

ConferenceOklahoma State University Center for Health Sciences Research Day 2020
CountryUnited States
CityTulsa
Period27/02/2028/02/20

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    Johnson, C., Davis, R., Buck, D. J., & McCracken, K. (2020). Effects of social defeat on iK-ba inflammatory signaling in male c57BL/6J. Poster session presented at Oklahoma State University Center for Health Sciences Research Day 2020, Tulsa, United States. https://shareok.org/handle/11244/324212