Effects of Sex Steroids on Myocardial Anoxic Resistance

Loren G. Martin, George M. Brenner, Kirby L. Jarolim, Martin Banschbach, David L. Coons, Amanda K. Wolfe

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Eight treatment groups of CD strain castrate male or female rats were injected daily with cottonseed oil (sham), testosterone propionate (50 µg/100 g body wt), estradiol benzoate (7 µg/100 g body wt), or a combination of both steroids dissolved in cottonseed oil. These physiologic replacement dosages of sex steroids, determined by bioassay procedures, were injected in a 0.1-ml bolus of cottonseed oil daily (intraperitoneally) for 16 weeks. Myocardial anoxic resistance was quantified by means of an in vitro right ventricular strip preparation that evaluated the ability of the isolated right ventricle to maintain contractions in response to electrical pacing at 1 Hz after 10 min of anoxia. While this parameter was elevated 2- to 3-fold in the estrogen-treated groups of male and female castrates compared with the sham (oil)-injected groups, neither testosterone treatment alone nor combination steroid treatment produced anoxic resistance values that differed significantly from those of the sham-injected animals. Thus, although estrogen alone may afford anoxic protection to the myocardium, testosterone is able to abolish this hormone-induced protection.

Original languageEnglish
Pages (from-to)288-294
Number of pages7
JournalProceedings of the Society for Experimental Biology and Medicine
Volume202
Issue number3
DOIs
StatePublished - 1 Jan 1993

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Cottonseed Oil
Steroids
Testosterone
Estrogens
Testosterone Propionate
Bioassay
Biological Assay
Heart Ventricles
Rats
Myocardium
Oils
Animals
Hormones

Cite this

Martin, Loren G. ; Brenner, George M. ; Jarolim, Kirby L. ; Banschbach, Martin ; Coons, David L. ; Wolfe, Amanda K. / Effects of Sex Steroids on Myocardial Anoxic Resistance. In: Proceedings of the Society for Experimental Biology and Medicine. 1993 ; Vol. 202, No. 3. pp. 288-294.
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Effects of Sex Steroids on Myocardial Anoxic Resistance. / Martin, Loren G.; Brenner, George M.; Jarolim, Kirby L.; Banschbach, Martin; Coons, David L.; Wolfe, Amanda K.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 202, No. 3, 01.01.1993, p. 288-294.

Research output: Contribution to journalArticle

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