Effects of laser immunotherapy on tumor microenvironment

Joseph T. Acquaviva, Ethan W. Wood, Aamr Hasanjee, Wei R. Chen, Melville B. Vaughan

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

The microenvironments of tumors are involved in a complex and reciprocal dialog with surrounding cancer cells. Any novel treatment must consider the impact of the therapy on the microenvironment. Recently, clinical trials with laser immunotherapy (LIT) have proven to effectively treat patients with late-stage, metastatic breast cancer and melanoma. LIT is the synergistic combination of phototherapy (laser irradiation) and immunological stimulation. One prominent cell type found in the tumor stroma is the fibroblast. Fibroblast cells can secrete different growth factors and extracellular matrix modifying molecules. Furthermore, fibroblast cells found in the tumor stroma often express alpha smooth muscle actin. These particular fibroblasts are coined cancer-associated fibroblast cells (CAFs). CAFs are known to facilitate the malignant progression of tumors. A collagen lattice assay with human fibroblast cells is used to elucidate the effects LIT has on the microenvironment of tumors. Changes in the contraction of the lattice, the differentiation of the fibroblast cells, as well as the proliferation of the fibroblast cells will be determined.

Original languageEnglish
Title of host publicationBiophotonics and Immune Responses IX
PublisherSPIE
ISBN (Print)9780819498571
DOIs
StatePublished - 2014
Externally publishedYes
EventBiophotonics and Immune Responses IX - San Francisco, CA, United States
Duration: 3 Feb 20143 Feb 2014

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8944
ISSN (Print)1605-7422

Conference

ConferenceBiophotonics and Immune Responses IX
Country/TerritoryUnited States
CitySan Francisco, CA
Period3/02/143/02/14

Keywords

  • Cancer-associated fibroblast cells
  • Collagen lattice
  • Fibroblast cells
  • Immunostimulant
  • Laser immunotherapy
  • Microenvironments
  • Phototherapy
  • Tumors

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