TY - GEN
T1 - Effects of interstitial laser immunotherapy for the treatment of metastatic cancer
AU - Bahavar, Cody
AU - Goddard, Jessica
AU - Sikes, Allie
AU - Boarman, Ellen
AU - Nordquist, Robert E.
AU - Hode, Tomas
AU - Liu, Hong
AU - Chen, Wei R.
PY - 2013/4/12
Y1 - 2013/4/12
N2 - Laser immunotherapy (LIT) uses laser irradiation and immunological stimulation to treat metastatic cancers. The current mode of operation of LIT is through dye-enhanced non-invasive irradiation. Although this treatment has given promising results, there are still a number of challenges with this method, such as limited light penetration for deep tumors and strong light absorption by highly pigmented skins. Interstitial laser immunotherapy (ILIT), using a cylindrical diffuser, is designed to overcome these limitations. In this study, rat tumors were treated by ILIT with an 805 nm laser and varying doses of glycated chitosan, an immunological stimulant. The goal was to observe the effects of differing doses of the stimulant on the survival of the tumor-bearing rats. The results suggested that the optimal dose of glycated chitosan is in the range of 0.1 to 0.3 ml per rat tumor.
AB - Laser immunotherapy (LIT) uses laser irradiation and immunological stimulation to treat metastatic cancers. The current mode of operation of LIT is through dye-enhanced non-invasive irradiation. Although this treatment has given promising results, there are still a number of challenges with this method, such as limited light penetration for deep tumors and strong light absorption by highly pigmented skins. Interstitial laser immunotherapy (ILIT), using a cylindrical diffuser, is designed to overcome these limitations. In this study, rat tumors were treated by ILIT with an 805 nm laser and varying doses of glycated chitosan, an immunological stimulant. The goal was to observe the effects of differing doses of the stimulant on the survival of the tumor-bearing rats. The results suggested that the optimal dose of glycated chitosan is in the range of 0.1 to 0.3 ml per rat tumor.
KW - cylindrical diffusion
KW - glycated chitosan
KW - immunological stimulant
KW - interstitial laser irradiation
KW - optimization of operations
KW - Rat tumor
UR - http://www.scopus.com/inward/record.url?scp=84875926537&partnerID=8YFLogxK
U2 - 10.1117/12.2006462
DO - 10.1117/12.2006462
M3 - Conference contribution
AN - SCOPUS:84875926537
SN - 9780819493514
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Biophotonics and Immune Responses VIII
T2 - Biophotonics and Immune Responses VIII
Y2 - 4 February 2013 through 4 February 2013
ER -