Effects of interstitial laser immunotherapy for the treatment of metastatic cancer

Cody Bahavar, Jessica Goddard, Allie Sikes, Ellen Boarman, Robert E. Nordquist, Tomas Hode, Hong Liu, Wei R. Chen

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Laser immunotherapy (LIT) uses laser irradiation and immunological stimulation to treat metastatic cancers. The current mode of operation of LIT is through dye-enhanced non-invasive irradiation. Although this treatment has given promising results, there are still a number of challenges with this method, such as limited light penetration for deep tumors and strong light absorption by highly pigmented skins. Interstitial laser immunotherapy (ILIT), using a cylindrical diffuser, is designed to overcome these limitations. In this study, rat tumors were treated by ILIT with an 805 nm laser and varying doses of glycated chitosan, an immunological stimulant. The goal was to observe the effects of differing doses of the stimulant on the survival of the tumor-bearing rats. The results suggested that the optimal dose of glycated chitosan is in the range of 0.1 to 0.3 ml per rat tumor.

Original languageEnglish
Title of host publicationBiophotonics and Immune Responses VIII
StatePublished - 12 Apr 2013
EventBiophotonics and Immune Responses VIII - San Francisco, CA, United States
Duration: 4 Feb 20134 Feb 2013

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceBiophotonics and Immune Responses VIII
Country/TerritoryUnited States
CitySan Francisco, CA


  • cylindrical diffusion
  • glycated chitosan
  • immunological stimulant
  • interstitial laser irradiation
  • optimization of operations
  • Rat tumor


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