EFFECTS OF ANF PROHORMONE PEPTIDES IN CONSCIOUS PRIMATES

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

1. Recent studies suggest that amino‐terminal peptides from the atrial natriuretic factor (ANF) prohormone are natriuretic. 2. The effects of pro ANF 31–67 and ANF 99–126 on renal function were studied in conscious non‐human primates (Macaca fuscicularis). 3. Results show that pro ANF 31–67 and ANF 99–126 are diuretic and natriuretic and that when the two peptides are given in combination sodium excretion increases in an additive fashion. 4. These results indicate that multiple peptides from the ANF prohormone are natriuretic. Furthermore, these findings suggest that the combined action of these peptides causes the natriuresis that occurs after the release of endogenous atrial peptides.

Original languageEnglish
Pages (from-to)125-129
Number of pages5
JournalClinical and Experimental Pharmacology and Physiology
Volume22
Issue number2
DOIs
StatePublished - 1 Jan 1995

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Atrial Natriuretic Factor
Primates
Peptides
Natriuresis
Macaca
Diuretics
Sodium
Kidney

Keywords

  • atrial natriuretic factor
  • atrial natriuretic factor prohormone
  • natriuresis
  • sodium excretion.

Cite this

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title = "EFFECTS OF ANF PROHORMONE PEPTIDES IN CONSCIOUS PRIMATES",
abstract = "1. Recent studies suggest that amino‐terminal peptides from the atrial natriuretic factor (ANF) prohormone are natriuretic. 2. The effects of pro ANF 31–67 and ANF 99–126 on renal function were studied in conscious non‐human primates (Macaca fuscicularis). 3. Results show that pro ANF 31–67 and ANF 99–126 are diuretic and natriuretic and that when the two peptides are given in combination sodium excretion increases in an additive fashion. 4. These results indicate that multiple peptides from the ANF prohormone are natriuretic. Furthermore, these findings suggest that the combined action of these peptides causes the natriuresis that occurs after the release of endogenous atrial peptides.",
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EFFECTS OF ANF PROHORMONE PEPTIDES IN CONSCIOUS PRIMATES. / Benjamin, Bruce.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 22, No. 2, 01.01.1995, p. 125-129.

Research output: Contribution to journalArticle

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AB - 1. Recent studies suggest that amino‐terminal peptides from the atrial natriuretic factor (ANF) prohormone are natriuretic. 2. The effects of pro ANF 31–67 and ANF 99–126 on renal function were studied in conscious non‐human primates (Macaca fuscicularis). 3. Results show that pro ANF 31–67 and ANF 99–126 are diuretic and natriuretic and that when the two peptides are given in combination sodium excretion increases in an additive fashion. 4. These results indicate that multiple peptides from the ANF prohormone are natriuretic. Furthermore, these findings suggest that the combined action of these peptides causes the natriuresis that occurs after the release of endogenous atrial peptides.

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