Effects of altitude acclimatization on fluid regulatory hormone response to submaximal exercise

P. B. Rock, W. J. Kraemer, C. S. Fulco, L. A. Trad, M. K. Malconian, M. S. Rose, P. M. Young, A. Cymerman

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

To determine the effect of altitude acclimatization on plasma levels of atrial natriuretic peptide (ANP) during submaximal exercise and its relationship with renin and aldosterone, seven male volunteers aged 17-23 yr exercised to exhaustion on a cycle ergometer at 80-85% of their maximum O2 uptake at sea level (SL; 50 m), during 1 h in a hypobaric chamber [acute altitude (AA); 4,300 m], and after 14 or 16 days of residence on the summit of Pikes Peak, CO [chronic altitude (CA); 4,300 m]. Plasma samples taken before exercise, 10 min after the start of exercise, and 5 min postexercise were analyzed for ANP, plasma renin activity (PRA), and aldosterone (ALDO). ANP showed a progressive increase from rest to postexercise [7.49 ± 1.63 to 11.32 ± 1.80 (SE) pmol/ml and 6.05 ± 2.55 to 10.38 ± 7.20 pmol/ml; P = 0.049, exercise] at SL and AA, respectively, but not at CA (P = 0.039, altitude). Similarly, PRA and ALDO rose from rest to postexercise (P < 0.001, exercise), but the rise in ALDO with exercise was less during AA than during SL and CA (P = 0.002, phase). The decreased ANP levels during exercise after altitude acclimatization, with no change in PRA and ALDO, suggest that ANP has little effect on PRA and ALDO under these conditions.

Original languageEnglish
Pages (from-to)1208-1215
Number of pages8
JournalJournal of Applied Physiology
Volume75
Issue number3
StatePublished - 1 Jan 1993

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Acclimatization
Hormones
Exercise
Aldosterone
Atrial Natriuretic Factor
Renin
Esocidae
Carbon Monoxide
Oceans and Seas
Volunteers

Keywords

  • acute mountain sickness
  • aldosterone
  • atrial natriuretic peptide
  • hypoxia
  • renin

Cite this

Rock, P. B., Kraemer, W. J., Fulco, C. S., Trad, L. A., Malconian, M. K., Rose, M. S., ... Cymerman, A. (1993). Effects of altitude acclimatization on fluid regulatory hormone response to submaximal exercise. Journal of Applied Physiology, 75(3), 1208-1215.
Rock, P. B. ; Kraemer, W. J. ; Fulco, C. S. ; Trad, L. A. ; Malconian, M. K. ; Rose, M. S. ; Young, P. M. ; Cymerman, A. / Effects of altitude acclimatization on fluid regulatory hormone response to submaximal exercise. In: Journal of Applied Physiology. 1993 ; Vol. 75, No. 3. pp. 1208-1215.
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abstract = "To determine the effect of altitude acclimatization on plasma levels of atrial natriuretic peptide (ANP) during submaximal exercise and its relationship with renin and aldosterone, seven male volunteers aged 17-23 yr exercised to exhaustion on a cycle ergometer at 80-85{\%} of their maximum O2 uptake at sea level (SL; 50 m), during 1 h in a hypobaric chamber [acute altitude (AA); 4,300 m], and after 14 or 16 days of residence on the summit of Pikes Peak, CO [chronic altitude (CA); 4,300 m]. Plasma samples taken before exercise, 10 min after the start of exercise, and 5 min postexercise were analyzed for ANP, plasma renin activity (PRA), and aldosterone (ALDO). ANP showed a progressive increase from rest to postexercise [7.49 ± 1.63 to 11.32 ± 1.80 (SE) pmol/ml and 6.05 ± 2.55 to 10.38 ± 7.20 pmol/ml; P = 0.049, exercise] at SL and AA, respectively, but not at CA (P = 0.039, altitude). Similarly, PRA and ALDO rose from rest to postexercise (P < 0.001, exercise), but the rise in ALDO with exercise was less during AA than during SL and CA (P = 0.002, phase). The decreased ANP levels during exercise after altitude acclimatization, with no change in PRA and ALDO, suggest that ANP has little effect on PRA and ALDO under these conditions.",
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Rock, PB, Kraemer, WJ, Fulco, CS, Trad, LA, Malconian, MK, Rose, MS, Young, PM & Cymerman, A 1993, 'Effects of altitude acclimatization on fluid regulatory hormone response to submaximal exercise', Journal of Applied Physiology, vol. 75, no. 3, pp. 1208-1215.

Effects of altitude acclimatization on fluid regulatory hormone response to submaximal exercise. / Rock, P. B.; Kraemer, W. J.; Fulco, C. S.; Trad, L. A.; Malconian, M. K.; Rose, M. S.; Young, P. M.; Cymerman, A.

In: Journal of Applied Physiology, Vol. 75, No. 3, 01.01.1993, p. 1208-1215.

Research output: Contribution to journalArticle

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T1 - Effects of altitude acclimatization on fluid regulatory hormone response to submaximal exercise

AU - Rock, P. B.

AU - Kraemer, W. J.

AU - Fulco, C. S.

AU - Trad, L. A.

AU - Malconian, M. K.

AU - Rose, M. S.

AU - Young, P. M.

AU - Cymerman, A.

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N2 - To determine the effect of altitude acclimatization on plasma levels of atrial natriuretic peptide (ANP) during submaximal exercise and its relationship with renin and aldosterone, seven male volunteers aged 17-23 yr exercised to exhaustion on a cycle ergometer at 80-85% of their maximum O2 uptake at sea level (SL; 50 m), during 1 h in a hypobaric chamber [acute altitude (AA); 4,300 m], and after 14 or 16 days of residence on the summit of Pikes Peak, CO [chronic altitude (CA); 4,300 m]. Plasma samples taken before exercise, 10 min after the start of exercise, and 5 min postexercise were analyzed for ANP, plasma renin activity (PRA), and aldosterone (ALDO). ANP showed a progressive increase from rest to postexercise [7.49 ± 1.63 to 11.32 ± 1.80 (SE) pmol/ml and 6.05 ± 2.55 to 10.38 ± 7.20 pmol/ml; P = 0.049, exercise] at SL and AA, respectively, but not at CA (P = 0.039, altitude). Similarly, PRA and ALDO rose from rest to postexercise (P < 0.001, exercise), but the rise in ALDO with exercise was less during AA than during SL and CA (P = 0.002, phase). The decreased ANP levels during exercise after altitude acclimatization, with no change in PRA and ALDO, suggest that ANP has little effect on PRA and ALDO under these conditions.

AB - To determine the effect of altitude acclimatization on plasma levels of atrial natriuretic peptide (ANP) during submaximal exercise and its relationship with renin and aldosterone, seven male volunteers aged 17-23 yr exercised to exhaustion on a cycle ergometer at 80-85% of their maximum O2 uptake at sea level (SL; 50 m), during 1 h in a hypobaric chamber [acute altitude (AA); 4,300 m], and after 14 or 16 days of residence on the summit of Pikes Peak, CO [chronic altitude (CA); 4,300 m]. Plasma samples taken before exercise, 10 min after the start of exercise, and 5 min postexercise were analyzed for ANP, plasma renin activity (PRA), and aldosterone (ALDO). ANP showed a progressive increase from rest to postexercise [7.49 ± 1.63 to 11.32 ± 1.80 (SE) pmol/ml and 6.05 ± 2.55 to 10.38 ± 7.20 pmol/ml; P = 0.049, exercise] at SL and AA, respectively, but not at CA (P = 0.039, altitude). Similarly, PRA and ALDO rose from rest to postexercise (P < 0.001, exercise), but the rise in ALDO with exercise was less during AA than during SL and CA (P = 0.002, phase). The decreased ANP levels during exercise after altitude acclimatization, with no change in PRA and ALDO, suggest that ANP has little effect on PRA and ALDO under these conditions.

KW - acute mountain sickness

KW - aldosterone

KW - atrial natriuretic peptide

KW - hypoxia

KW - renin

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Rock PB, Kraemer WJ, Fulco CS, Trad LA, Malconian MK, Rose MS et al. Effects of altitude acclimatization on fluid regulatory hormone response to submaximal exercise. Journal of Applied Physiology. 1993 Jan 1;75(3):1208-1215.