Effect of Bilateral Atrial Appendectomy on Postprandial Sodium Excretion in Conscious Monkeys

Bruce Benjamin, Thomas V. Peterson

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We have shown that bilateral atrial appendectomy attenuates the increase in atrial natriuretic factor and sodium excretion that occurs after acute blood volume expansion. These findings suggest that the atrial appendages influence renal sodium excretion. The purpose of the present study was to determine whether atrial appendectomy alters the increase in sodium excretion that occurs postprandially. One to two weeks after surgery, conscious monkeys (Macaca fascicularis) were given a meal through a nasogastric tube. The meal consisted of water (20 ml/kg), sodium (2.5 mmol/kg), carbohydrate (2.65 g/kg), protein (0.68 g/kg), and fat (0.89 g/kg). Postprandial changes in renal function were monitored for 210 min after the meal was started. In the sham animals, urine flow increased from 0.23 × 0.04 to 0.55 × 0.05 ml/min, sodium excretion increased from 28.6 × 7.8 to 84.4 × 12.3 μmol/min and fractional sodium excretion increased from 1.35 × 0.38% to 3.06 × 0.43%. Bilateral atrial appendectomy (ATX) significantly attenuated the renal responses to the meal. Urine flow in the ATX animals increased from 0.19 × 0.03 to 0.30 × 0.02 ml/min, sodium excretion increased from 26.5 × 5.8 to 45.8 × 15.2 μmol/min, and fractional sodium excretion increased from 0.99 × 0.02% to 1.53 × 0.34%. Postprandial changes in renal and systemic hemodynamics were also monitored and were similar in both groups. Plasma levels of atrial natriuretic factor were also similar in both groups and did not increase postprandially. These findings demonstrate that bilateral atrial appendectomy attenuates postprandial-induced increases in sodium excretion by mechanisms that do not involve an increase in atrial natriuretic factor.

Original languageEnglish
Pages (from-to)45-52
Number of pages8
JournalProceedings of the Society for Experimental Biology and Medicine
Volume206
Issue number1
DOIs
StatePublished - 1 Jan 1994

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Appendectomy
Haplorhini
Sodium
Meals
Atrial Natriuretic Factor
Kidney
Animals
Urine
Atrial Appendage
Macaca fascicularis
Hemodynamics
Blood Volume
Surgery
Blood
Fats
Carbohydrates
Plasmas
Water

Cite this

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title = "Effect of Bilateral Atrial Appendectomy on Postprandial Sodium Excretion in Conscious Monkeys",
abstract = "We have shown that bilateral atrial appendectomy attenuates the increase in atrial natriuretic factor and sodium excretion that occurs after acute blood volume expansion. These findings suggest that the atrial appendages influence renal sodium excretion. The purpose of the present study was to determine whether atrial appendectomy alters the increase in sodium excretion that occurs postprandially. One to two weeks after surgery, conscious monkeys (Macaca fascicularis) were given a meal through a nasogastric tube. The meal consisted of water (20 ml/kg), sodium (2.5 mmol/kg), carbohydrate (2.65 g/kg), protein (0.68 g/kg), and fat (0.89 g/kg). Postprandial changes in renal function were monitored for 210 min after the meal was started. In the sham animals, urine flow increased from 0.23 × 0.04 to 0.55 × 0.05 ml/min, sodium excretion increased from 28.6 × 7.8 to 84.4 × 12.3 μmol/min and fractional sodium excretion increased from 1.35 × 0.38{\%} to 3.06 × 0.43{\%}. Bilateral atrial appendectomy (ATX) significantly attenuated the renal responses to the meal. Urine flow in the ATX animals increased from 0.19 × 0.03 to 0.30 × 0.02 ml/min, sodium excretion increased from 26.5 × 5.8 to 45.8 × 15.2 μmol/min, and fractional sodium excretion increased from 0.99 × 0.02{\%} to 1.53 × 0.34{\%}. Postprandial changes in renal and systemic hemodynamics were also monitored and were similar in both groups. Plasma levels of atrial natriuretic factor were also similar in both groups and did not increase postprandially. These findings demonstrate that bilateral atrial appendectomy attenuates postprandial-induced increases in sodium excretion by mechanisms that do not involve an increase in atrial natriuretic factor.",
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Effect of Bilateral Atrial Appendectomy on Postprandial Sodium Excretion in Conscious Monkeys. / Benjamin, Bruce; Peterson, Thomas V.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 206, No. 1, 01.01.1994, p. 45-52.

Research output: Contribution to journalArticle

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