Abstract
Background: Deliberate antibiotic use (AU) in early life may contribute to asthma. Although a number of published studies have tested AU in conjuction with the hygiene hypothesis, the results have been conflicting and little is known about the relationship between AU and asthma in the children with high atopic risk.
Aims: To examine the association between the use of specific therapeutic antibiotics in the first year of life and wheezing by 36 months among high atopic risk children.
Methods: A multi-center prospective cohort study was conducted among children at high-risk for atopic sensitization. A validated questionnaire was used to prospectively collect information on antibiotic use and potential risk factors for wheezing from parents or guardians of 606 children from 3 European countries at 6, 12, 24, and 36 months of age. Linear logistic regression model was used to adjust for potential confounders and estimate odds ratios (OR) with 95% confidence interval (CL) associated with antibiotic use for development of wheezing Results: Only macrolides’ use in the first year of life was associated with increasing risk for wheezing, after adjusting for gender, socioeconomic status, breast feeding, tobacco smoke exposure of the infants, family history of asthma, and respiratory infection (OR=3.24; 95%CI 1.47-7.30). Among the children with respiratory infection, similar associations were observed for macrolides use (OR=3.42; 95%CI 1.46-8.01) and lower respiratory tract infection (OR=4.60; 95%CI 2.19-9.66).
Conclusions: In European children with a familial risk for allergic disease, we found a positive association between macrolides use in the first year of life and wheezing until 36 months. Key words: antibiotic use, wheezing, prospective cohort
Aims: To examine the association between the use of specific therapeutic antibiotics in the first year of life and wheezing by 36 months among high atopic risk children.
Methods: A multi-center prospective cohort study was conducted among children at high-risk for atopic sensitization. A validated questionnaire was used to prospectively collect information on antibiotic use and potential risk factors for wheezing from parents or guardians of 606 children from 3 European countries at 6, 12, 24, and 36 months of age. Linear logistic regression model was used to adjust for potential confounders and estimate odds ratios (OR) with 95% confidence interval (CL) associated with antibiotic use for development of wheezing Results: Only macrolides’ use in the first year of life was associated with increasing risk for wheezing, after adjusting for gender, socioeconomic status, breast feeding, tobacco smoke exposure of the infants, family history of asthma, and respiratory infection (OR=3.24; 95%CI 1.47-7.30). Among the children with respiratory infection, similar associations were observed for macrolides use (OR=3.42; 95%CI 1.46-8.01) and lower respiratory tract infection (OR=4.60; 95%CI 2.19-9.66).
Conclusions: In European children with a familial risk for allergic disease, we found a positive association between macrolides use in the first year of life and wheezing until 36 months. Key words: antibiotic use, wheezing, prospective cohort
| Original language | American English |
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| State | Published - 15 Aug 2014 |