Drosophila as a genetic model for studying pathogenic human viruses

Tamara T. Hughes, Amanda L. Allen, Joseph E. Bardin, Megan N. Christian, Kansei Daimon, Kelsey D. Dozier, Caom L. Hansen, Lisa M. Holcomb, Joseph Ahlander

Research output: Contribution to journalShort survey

27 Citations (Scopus)

Abstract

Viruses are infectious particles whose viability is dependent on the cells of living organisms, such as bacteria, plants, and animals. It is of great interest to discover how viruses function inside host cells in order to develop therapies to treat virally infected organisms. The fruit fly Drosophila melanogaster is an excellent model system for studying the molecular mechanisms of replication, amplification, and cellular consequences of human viruses. In this review, we describe the advantages of using Drosophila as a model system to study human viruses, and highlight how Drosophila has been used to provide unique insight into the gene function of several pathogenic viruses. We also propose possible directions for future research in this area.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalVirology
Volume423
Issue number1
DOIs
StatePublished - 5 Feb 2012
Externally publishedYes

Fingerprint

Genetic Models
Drosophila
Viruses
Drosophila melanogaster
Diptera
Virion
Fruit
Bacteria
Genes
Therapeutics

Keywords

  • Drosophila
  • GAL4/UAS system
  • Human pathogens
  • Model organism
  • Transgenic expression
  • Viruses

Cite this

Hughes, T. T., Allen, A. L., Bardin, J. E., Christian, M. N., Daimon, K., Dozier, K. D., ... Ahlander, J. (2012). Drosophila as a genetic model for studying pathogenic human viruses. Virology, 423(1), 1-5. https://doi.org/10.1016/j.virol.2011.11.016
Hughes, Tamara T. ; Allen, Amanda L. ; Bardin, Joseph E. ; Christian, Megan N. ; Daimon, Kansei ; Dozier, Kelsey D. ; Hansen, Caom L. ; Holcomb, Lisa M. ; Ahlander, Joseph. / Drosophila as a genetic model for studying pathogenic human viruses. In: Virology. 2012 ; Vol. 423, No. 1. pp. 1-5.
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Hughes, TT, Allen, AL, Bardin, JE, Christian, MN, Daimon, K, Dozier, KD, Hansen, CL, Holcomb, LM & Ahlander, J 2012, 'Drosophila as a genetic model for studying pathogenic human viruses', Virology, vol. 423, no. 1, pp. 1-5. https://doi.org/10.1016/j.virol.2011.11.016

Drosophila as a genetic model for studying pathogenic human viruses. / Hughes, Tamara T.; Allen, Amanda L.; Bardin, Joseph E.; Christian, Megan N.; Daimon, Kansei; Dozier, Kelsey D.; Hansen, Caom L.; Holcomb, Lisa M.; Ahlander, Joseph.

In: Virology, Vol. 423, No. 1, 05.02.2012, p. 1-5.

Research output: Contribution to journalShort survey

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Hughes TT, Allen AL, Bardin JE, Christian MN, Daimon K, Dozier KD et al. Drosophila as a genetic model for studying pathogenic human viruses. Virology. 2012 Feb 5;423(1):1-5. https://doi.org/10.1016/j.virol.2011.11.016