Drosophila as a genetic model for studying pathogenic human viruses

Tamara T. Hughes; Amanda L. Allen; Joseph E. Bardin; Megan N. Christian; Kansei Daimon; Kelsey D. Dozier; Caom L. Hansen; Lisa M. Holcomb; Joseph Ahlander

doi:10.1016/j.virol.2011.11.016

Drosophila as a genetic model for studying pathogenic human viruses

Tamara T. Hughes, Amanda L. Allen, Joseph E. Bardin, Megan N. Christian, Kansei Daimon, Kelsey D. Dozier, Caom L. Hansen, Lisa M. Holcomb, Joseph Ahlander

Research output: Contribution to journal › Short survey › peer-review

53 Scopus citations

Abstract

Viruses are infectious particles whose viability is dependent on the cells of living organisms, such as bacteria, plants, and animals. It is of great interest to discover how viruses function inside host cells in order to develop therapies to treat virally infected organisms. The fruit fly Drosophila melanogaster is an excellent model system for studying the molecular mechanisms of replication, amplification, and cellular consequences of human viruses. In this review, we describe the advantages of using Drosophila as a model system to study human viruses, and highlight how Drosophila has been used to provide unique insight into the gene function of several pathogenic viruses. We also propose possible directions for future research in this area.

Original language	English
Pages (from-to)	1-5
Number of pages	5
Journal	Virology
Volume	423
Issue number	1
DOIs	https://doi.org/10.1016/j.virol.2011.11.016
State	Published - 5 Feb 2012
Externally published	Yes

Keywords

Drosophila
GAL4/UAS system
Human pathogens
Model organism
Transgenic expression
Viruses

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10.1016/j.virol.2011.11.016

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title = "Drosophila as a genetic model for studying pathogenic human viruses",

abstract = "Viruses are infectious particles whose viability is dependent on the cells of living organisms, such as bacteria, plants, and animals. It is of great interest to discover how viruses function inside host cells in order to develop therapies to treat virally infected organisms. The fruit fly Drosophila melanogaster is an excellent model system for studying the molecular mechanisms of replication, amplification, and cellular consequences of human viruses. In this review, we describe the advantages of using Drosophila as a model system to study human viruses, and highlight how Drosophila has been used to provide unique insight into the gene function of several pathogenic viruses. We also propose possible directions for future research in this area.",

keywords = "Drosophila, GAL4/UAS system, Human pathogens, Model organism, Transgenic expression, Viruses",

author = "Hughes, {Tamara T.} and Allen, {Amanda L.} and Bardin, {Joseph E.} and Christian, {Megan N.} and Kansei Daimon and Dozier, {Kelsey D.} and Hansen, {Caom L.} and Holcomb, {Lisa M.} and Joseph Ahlander",

note = "Funding Information: This publication was made possible by Grant Number DUE-0856396 from the National Science Foundation and by Grant Number P20RR016478 from the National Center for Research Resources (NCRR) , a component of the National Institutes of Health (NIH). We are also grateful to Dr. Brian Ceresa for helpful comments during the preparation of the manuscript.",

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doi = "10.1016/j.virol.2011.11.016",

language = "English",

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AU - Hughes, Tamara T.

AU - Allen, Amanda L.

AU - Bardin, Joseph E.

AU - Christian, Megan N.

AU - Daimon, Kansei

AU - Dozier, Kelsey D.

AU - Hansen, Caom L.

AU - Holcomb, Lisa M.

AU - Ahlander, Joseph

N1 - Funding Information: This publication was made possible by Grant Number DUE-0856396 from the National Science Foundation and by Grant Number P20RR016478 from the National Center for Research Resources (NCRR) , a component of the National Institutes of Health (NIH). We are also grateful to Dr. Brian Ceresa for helpful comments during the preparation of the manuscript.

PY - 2012/2/5

Y1 - 2012/2/5

N2 - Viruses are infectious particles whose viability is dependent on the cells of living organisms, such as bacteria, plants, and animals. It is of great interest to discover how viruses function inside host cells in order to develop therapies to treat virally infected organisms. The fruit fly Drosophila melanogaster is an excellent model system for studying the molecular mechanisms of replication, amplification, and cellular consequences of human viruses. In this review, we describe the advantages of using Drosophila as a model system to study human viruses, and highlight how Drosophila has been used to provide unique insight into the gene function of several pathogenic viruses. We also propose possible directions for future research in this area.

AB - Viruses are infectious particles whose viability is dependent on the cells of living organisms, such as bacteria, plants, and animals. It is of great interest to discover how viruses function inside host cells in order to develop therapies to treat virally infected organisms. The fruit fly Drosophila melanogaster is an excellent model system for studying the molecular mechanisms of replication, amplification, and cellular consequences of human viruses. In this review, we describe the advantages of using Drosophila as a model system to study human viruses, and highlight how Drosophila has been used to provide unique insight into the gene function of several pathogenic viruses. We also propose possible directions for future research in this area.

KW - Drosophila

KW - GAL4/UAS system

KW - Human pathogens

KW - Model organism

KW - Transgenic expression

KW - Viruses

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VL - 423

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EP - 5

JO - Virology

JF - Virology

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Drosophila as a genetic model for studying pathogenic human viruses

Abstract

Keywords

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