Dopamine D3 receptor density elevation in aged Fischer-344 x Brown-Norway (F1) rats

David Wallace, Rosemarie M. Booze

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The density of dopamine D3 receptors was determined in young (4-month-old) and aged (37-month-old) Fischer-344 x Brown-Norway (F1) male rats using the putative D3 receptor-preferring agonist, [3H](+)-7-hydroxy-2- N,N-di-n-propylamino)tetralin ([3H](+)-7-OH-PAT). In the presence of the non-hydrolyzable GTP analog, 5'-guanylylimidodiphosphate (Gpp(NH)p), the density of dopamine D3 receptors in the striatum and nucleus accumbens was significantly increased (29-102%, respectively) in aged Fischer-344 x Brown-Norway (F1) rats compared to young adults. These findings suggest that dopaminergic activity in aged rats is compromised by increased D3 receptor density, resulting in altered striatal/nucleus accumbens function via presynaptic or postsynaptic modifications.

Original languageEnglish
Pages (from-to)283-285
Number of pages3
JournalEuropean Journal of Pharmacology
Volume308
Issue number3
DOIs
StatePublished - 25 Jul 1996

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Dopamine D3 Receptors
Nucleus Accumbens
Guanylyl Imidodiphosphate
Corpus Striatum
Norway
Guanosine Triphosphate
Young Adult

Keywords

  • Basal forebrain
  • Nucleus accumbens
  • Striatum

Cite this

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title = "Dopamine D3 receptor density elevation in aged Fischer-344 x Brown-Norway (F1) rats",
abstract = "The density of dopamine D3 receptors was determined in young (4-month-old) and aged (37-month-old) Fischer-344 x Brown-Norway (F1) male rats using the putative D3 receptor-preferring agonist, [3H](+)-7-hydroxy-2- N,N-di-n-propylamino)tetralin ([3H](+)-7-OH-PAT). In the presence of the non-hydrolyzable GTP analog, 5'-guanylylimidodiphosphate (Gpp(NH)p), the density of dopamine D3 receptors in the striatum and nucleus accumbens was significantly increased (29-102{\%}, respectively) in aged Fischer-344 x Brown-Norway (F1) rats compared to young adults. These findings suggest that dopaminergic activity in aged rats is compromised by increased D3 receptor density, resulting in altered striatal/nucleus accumbens function via presynaptic or postsynaptic modifications.",
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Dopamine D3 receptor density elevation in aged Fischer-344 x Brown-Norway (F1) rats. / Wallace, David; Booze, Rosemarie M.

In: European Journal of Pharmacology, Vol. 308, No. 3, 25.07.1996, p. 283-285.

Research output: Contribution to journalArticle

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AU - Wallace, David

AU - Booze, Rosemarie M.

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