Dopamine D3 receptor density elevation in aged Fischer-344 x Brown-Norway (F1) rats

David R. Wallace; Rosemarie M. Booze

doi:10.1016/0014-2999(96)00354-8

Dopamine D₃ receptor density elevation in aged Fischer-344 x Brown-Norway (F1) rats

David R. Wallace, Rosemarie M. Booze

Pharmacology and Physiology

Research output: Contribution to journal › Article › peer-review

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Abstract

The density of dopamine D₃ receptors was determined in young (4-month-old) and aged (37-month-old) Fischer-344 x Brown-Norway (F1) male rats using the putative D₃ receptor-preferring agonist, [³H](+)-7-hydroxy-2- N,N-di-n-propylamino)tetralin ([³H](+)-7-OH-PAT). In the presence of the non-hydrolyzable GTP analog, 5'-guanylylimidodiphosphate (Gpp(NH)p), the density of dopamine D₃ receptors in the striatum and nucleus accumbens was significantly increased (29-102%, respectively) in aged Fischer-344 x Brown-Norway (F1) rats compared to young adults. These findings suggest that dopaminergic activity in aged rats is compromised by increased D₃ receptor density, resulting in altered striatal/nucleus accumbens function via presynaptic or postsynaptic modifications.

Original language	English
Pages (from-to)	283-285
Number of pages	3
Journal	European Journal of Pharmacology
Volume	308
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(96)00354-8
State	Published - 25 Jul 1996

Keywords

Basal forebrain
Nucleus accumbens
Striatum

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title = "Dopamine D3 receptor density elevation in aged Fischer-344 x Brown-Norway (F1) rats",

abstract = "The density of dopamine D3 receptors was determined in young (4-month-old) and aged (37-month-old) Fischer-344 x Brown-Norway (F1) male rats using the putative D3 receptor-preferring agonist, [3H](+)-7-hydroxy-2- N,N-di-n-propylamino)tetralin ([3H](+)-7-OH-PAT). In the presence of the non-hydrolyzable GTP analog, 5'-guanylylimidodiphosphate (Gpp(NH)p), the density of dopamine D3 receptors in the striatum and nucleus accumbens was significantly increased (29-102%, respectively) in aged Fischer-344 x Brown-Norway (F1) rats compared to young adults. These findings suggest that dopaminergic activity in aged rats is compromised by increased D3 receptor density, resulting in altered striatal/nucleus accumbens function via presynaptic or postsynaptic modifications.",

keywords = "Basal forebrain, Nucleus accumbens, Striatum",

author = "Wallace, {David R.} and Booze, {Rosemarie M.}",

note = "Funding Information: This work was supported by grants DA06638, DA09160, AG10836 and AG10747 (to R.M.B.) and postdoctoral training grant AG00242 (to D.R.W) from the National Institutes of Health.",

year = "1996",

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doi = "10.1016/0014-2999(96)00354-8",

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AU - Booze, Rosemarie M.

N1 - Funding Information: This work was supported by grants DA06638, DA09160, AG10836 and AG10747 (to R.M.B.) and postdoctoral training grant AG00242 (to D.R.W) from the National Institutes of Health.

PY - 1996/7/25

Y1 - 1996/7/25

N2 - The density of dopamine D3 receptors was determined in young (4-month-old) and aged (37-month-old) Fischer-344 x Brown-Norway (F1) male rats using the putative D3 receptor-preferring agonist, [3H](+)-7-hydroxy-2- N,N-di-n-propylamino)tetralin ([3H](+)-7-OH-PAT). In the presence of the non-hydrolyzable GTP analog, 5'-guanylylimidodiphosphate (Gpp(NH)p), the density of dopamine D3 receptors in the striatum and nucleus accumbens was significantly increased (29-102%, respectively) in aged Fischer-344 x Brown-Norway (F1) rats compared to young adults. These findings suggest that dopaminergic activity in aged rats is compromised by increased D3 receptor density, resulting in altered striatal/nucleus accumbens function via presynaptic or postsynaptic modifications.

AB - The density of dopamine D3 receptors was determined in young (4-month-old) and aged (37-month-old) Fischer-344 x Brown-Norway (F1) male rats using the putative D3 receptor-preferring agonist, [3H](+)-7-hydroxy-2- N,N-di-n-propylamino)tetralin ([3H](+)-7-OH-PAT). In the presence of the non-hydrolyzable GTP analog, 5'-guanylylimidodiphosphate (Gpp(NH)p), the density of dopamine D3 receptors in the striatum and nucleus accumbens was significantly increased (29-102%, respectively) in aged Fischer-344 x Brown-Norway (F1) rats compared to young adults. These findings suggest that dopaminergic activity in aged rats is compromised by increased D3 receptor density, resulting in altered striatal/nucleus accumbens function via presynaptic or postsynaptic modifications.

KW - Basal forebrain

KW - Nucleus accumbens

KW - Striatum

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JO - European Journal of Pharmacology

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ER -

Dopamine D₃ receptor density elevation in aged Fischer-344 x Brown-Norway (F1) rats

Abstract

Keywords

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