Diversity and Inclusion in U.S. Knee Injury Clinical Trials: A Systematic Review and Meta-Analysis

Research output: Contribution to conferencePosterpeer-review

Abstract

Purpose: Knee injuries are a prevalent and significant concern, particularly among athletes and individuals with active lifestyles. Despite knee injury treatment advancements, inequity in care access frequently affects diverse populations. Our primary objective is to examine the diversity and inclusion of historically marginalized populations in clinical trials focused on knee injuries in the U.S.

Design Methods: Our systematic review and meta-analysis evaluated the diversity and representation of knee injury clinical trials published between 2018-2023. Relevant clinical trials were identified using medical literature databases. We evaluated studies using the Clinical trial Diversity Rating (CDR) framework to assess their inclusion across multiple demographic characteristics.

Results: A total of 13 studies met the inclusion criteria for the final meta-analysis. Only 1/13 (7.7%) received a ‘Fair’ representation score for race/ethnicity participation, and 1/13 (7.7%) received a ‘Poor’ representation score. The remaining 11/13 (84.6%) studies did not report information on the race/ethnicity of their participants. 8/13 (61.5%) trials received a ‘Good’ representation score when evaluating the inclusion of males and females, 3/13 (23.1%) were ‘Fair’, and 2/13 (15.4%) were ‘Poor’. None of the studies reported the number of participants aged ≥65.

Conclusion: The results of this study emphasize the need for knee injury clinical trials to have higher reporting standards for race and ethnicity and age of participants. Clearly reporting demographic information will help to ensure trials recruit and retain participants that are representative of the incidence of knee injuries in the population. The lack of diversity goals and insufficient reporting of racial and ethnic minority populations underscores the need for future research with increased generalizability and improved understanding of how knee injuries and treatments affect diverse populations.
Original languageAmerican English
Pages29
StatePublished - 13 Sep 2024
Event2024 Symposium on Tribal and Rural Innovations in Disparities and Equity for Health - Oklahoma State University College of Osteopathic Medicine at the Cherokee Nation, Tahlequah, United States
Duration: 13 Sep 202413 Sep 2024

Conference

Conference2024 Symposium on Tribal and Rural Innovations in Disparities and Equity for Health
Abbreviated titleSTRIDE 2024
Country/TerritoryUnited States
CityTahlequah
Period13/09/2413/09/24

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