Distribution of serotonin in the caudal neurosecretory complex - A light and electron microscopic study

Stewart L. Cohen, Kenneth Miller, Richard M. Kriebel

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The caudal neurosecretory complex (CNc) of poecilids has previously been shown to receive serotonergic inputs. In the present study, immunohistochemical techniques were applied at the light and electron microscopic levels to characterize serotonergic terminals in the neuroendocrine nucleus. A dense plexus of varicose fibers observed in the rostral CNc neuropil was absent in the spinal cords of deafferented fish, indicating that the origin of this input was extranuclear. Ultrastructural study revealed no direct contacts between labeled structures and neuroendocrine cells. Non-synaptic terminals (varicosities) were the predominantly labeled structures in the neuropil. Synaptic terminals were observed on cellular and axonal targets in the CNc. Small cells containing 70 nm dense-core vesicles received serotonergic input on their perikarya. Labeled synapses were also found on unlabeled axon terminals which made axoaxonal synapses on neuroendocrine processes. Non-synaptic terminals may be responsible for a variety of serotonin-mediated effects in the CNc. Synaptic interactions with local catecholaminergic and afferent cholinergic inputs to the CNc are likely.

Original languageEnglish
Pages (from-to)491-498
Number of pages8
JournalAnatomy and Embryology
Volume181
Issue number5
DOIs
StatePublished - 1 Jun 1990

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Neuropil
Presynaptic Terminals
Synapses
Serotonin
Electrons
Serotonin Agents
Light
Neuroendocrine Cells
Secretory Vesicles
Cholinergic Agents
Spinal Cord
Fishes

Keywords

  • Caudal Neurosecretory Complex
  • Monoamines
  • Neuroendocrine
  • Serotonin
  • Ultrastructure

Cite this

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abstract = "The caudal neurosecretory complex (CNc) of poecilids has previously been shown to receive serotonergic inputs. In the present study, immunohistochemical techniques were applied at the light and electron microscopic levels to characterize serotonergic terminals in the neuroendocrine nucleus. A dense plexus of varicose fibers observed in the rostral CNc neuropil was absent in the spinal cords of deafferented fish, indicating that the origin of this input was extranuclear. Ultrastructural study revealed no direct contacts between labeled structures and neuroendocrine cells. Non-synaptic terminals (varicosities) were the predominantly labeled structures in the neuropil. Synaptic terminals were observed on cellular and axonal targets in the CNc. Small cells containing 70 nm dense-core vesicles received serotonergic input on their perikarya. Labeled synapses were also found on unlabeled axon terminals which made axoaxonal synapses on neuroendocrine processes. Non-synaptic terminals may be responsible for a variety of serotonin-mediated effects in the CNc. Synaptic interactions with local catecholaminergic and afferent cholinergic inputs to the CNc are likely.",
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Distribution of serotonin in the caudal neurosecretory complex - A light and electron microscopic study. / Cohen, Stewart L.; Miller, Kenneth; Kriebel, Richard M.

In: Anatomy and Embryology, Vol. 181, No. 5, 01.06.1990, p. 491-498.

Research output: Contribution to journalArticle

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