Differential indicators of diabetes-induced oxidative stress in New Zealand White rabbits: Role of dietary vitamin E supplementation

Randall L. Davis, Christy L. Lavine, Melissa A. Arredondo, Patrick McMahon, Thomas E. Tenner

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Determination of reliable bioindicators of diabetes-induced oxidative stress and the role of dietary vitamin E supplementation were investigated. Blood (plasma) chemistries, lipid peroxidation (LPO), and antioxidant enzyme activities were measured over 12 weeks in New Zealand White rabbits (control, diabetic, and diabetic + vitamin E). Cholesterol and triglyceride levels did not correlate with diabetic state. Plasma LPO was influenced by diabetes and positively correlated with glucose concentration only, not cholesterol or triglycerides. Liver glutathione peroxidase (GPX) activity negatively correlated with glucose and triglyceride levels. Plasma and erythrocyte GPX activities positively correlated with glucose, cholesterol, and triglyceride concentrations. Liver superoxide dismutase activity positively correlated with glucose and cholesterol concentration. Vitamin E reduced plasma LPO, but did not affect the diabetic state. Thus, plasma LPO was the most reliable indicator of diabetes-induced oxidative stress. Antioxidant enzyme activities and types of reactive oxygen species generated were tissue dependent. Diabetes-induced oxidative stress is diminished by vitamin E supplementation.

Original languageEnglish
Pages (from-to)185-192
Number of pages8
JournalInternational Journal of Experimental Diabetes Research
Issue number3
Publication statusPublished - 1 Jul 2002



  • Antioxidant
  • Oxidative stress
  • Type 1 diabetes
  • Vitamin E

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