Differential indicators of diabetes-induced oxidative stress in New Zealand White rabbits: Role of dietary vitamin E supplementation

Randall Davis, Christy L. Lavine, Melissa A. Arredondo, Patrick McMahon, Thomas E. Tenner

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Determination of reliable bioindicators of diabetes-induced oxidative stress and the role of dietary vitamin E supplementation were investigated. Blood (plasma) chemistries, lipid peroxidation (LPO), and antioxidant enzyme activities were measured over 12 weeks in New Zealand White rabbits (control, diabetic, and diabetic + vitamin E). Cholesterol and triglyceride levels did not correlate with diabetic state. Plasma LPO was influenced by diabetes and positively correlated with glucose concentration only, not cholesterol or triglycerides. Liver glutathione peroxidase (GPX) activity negatively correlated with glucose and triglyceride levels. Plasma and erythrocyte GPX activities positively correlated with glucose, cholesterol, and triglyceride concentrations. Liver superoxide dismutase activity positively correlated with glucose and cholesterol concentration. Vitamin E reduced plasma LPO, but did not affect the diabetic state. Thus, plasma LPO was the most reliable indicator of diabetes-induced oxidative stress. Antioxidant enzyme activities and types of reactive oxygen species generated were tissue dependent. Diabetes-induced oxidative stress is diminished by vitamin E supplementation.

Original languageEnglish
Pages (from-to)185-192
Number of pages8
JournalInternational Journal of Experimental Diabetes Research
Volume3
Issue number3
DOIs
StatePublished - 1 Jul 2002

Fingerprint

Vitamin E
Oxidative Stress
Lipid Peroxidation
Rabbits
Triglycerides
Cholesterol
Glucose
Glutathione Peroxidase
Antioxidants
Liver
Enzymes
Superoxide Dismutase
Reactive Oxygen Species
Erythrocytes

Keywords

  • Antioxidant
  • Oxidative stress
  • Type 1 diabetes
  • Vitamin E

Cite this

@article{1db5f31894774e758dd0ffc3c39b0c77,
title = "Differential indicators of diabetes-induced oxidative stress in New Zealand White rabbits: Role of dietary vitamin E supplementation",
abstract = "Determination of reliable bioindicators of diabetes-induced oxidative stress and the role of dietary vitamin E supplementation were investigated. Blood (plasma) chemistries, lipid peroxidation (LPO), and antioxidant enzyme activities were measured over 12 weeks in New Zealand White rabbits (control, diabetic, and diabetic + vitamin E). Cholesterol and triglyceride levels did not correlate with diabetic state. Plasma LPO was influenced by diabetes and positively correlated with glucose concentration only, not cholesterol or triglycerides. Liver glutathione peroxidase (GPX) activity negatively correlated with glucose and triglyceride levels. Plasma and erythrocyte GPX activities positively correlated with glucose, cholesterol, and triglyceride concentrations. Liver superoxide dismutase activity positively correlated with glucose and cholesterol concentration. Vitamin E reduced plasma LPO, but did not affect the diabetic state. Thus, plasma LPO was the most reliable indicator of diabetes-induced oxidative stress. Antioxidant enzyme activities and types of reactive oxygen species generated were tissue dependent. Diabetes-induced oxidative stress is diminished by vitamin E supplementation.",
keywords = "Antioxidant, Oxidative stress, Type 1 diabetes, Vitamin E",
author = "Randall Davis and Lavine, {Christy L.} and Arredondo, {Melissa A.} and Patrick McMahon and Tenner, {Thomas E.}",
year = "2002",
month = "7",
day = "1",
doi = "10.1080/15604280214279",
language = "English",
volume = "3",
pages = "185--192",
journal = "International Journal of Experimental Diabetes Research",
issn = "1560-4284",
publisher = "Taylor and Francis Ltd.",
number = "3",

}

Differential indicators of diabetes-induced oxidative stress in New Zealand White rabbits : Role of dietary vitamin E supplementation. / Davis, Randall; Lavine, Christy L.; Arredondo, Melissa A.; McMahon, Patrick; Tenner, Thomas E.

In: International Journal of Experimental Diabetes Research, Vol. 3, No. 3, 01.07.2002, p. 185-192.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Differential indicators of diabetes-induced oxidative stress in New Zealand White rabbits

T2 - Role of dietary vitamin E supplementation

AU - Davis, Randall

AU - Lavine, Christy L.

AU - Arredondo, Melissa A.

AU - McMahon, Patrick

AU - Tenner, Thomas E.

PY - 2002/7/1

Y1 - 2002/7/1

N2 - Determination of reliable bioindicators of diabetes-induced oxidative stress and the role of dietary vitamin E supplementation were investigated. Blood (plasma) chemistries, lipid peroxidation (LPO), and antioxidant enzyme activities were measured over 12 weeks in New Zealand White rabbits (control, diabetic, and diabetic + vitamin E). Cholesterol and triglyceride levels did not correlate with diabetic state. Plasma LPO was influenced by diabetes and positively correlated with glucose concentration only, not cholesterol or triglycerides. Liver glutathione peroxidase (GPX) activity negatively correlated with glucose and triglyceride levels. Plasma and erythrocyte GPX activities positively correlated with glucose, cholesterol, and triglyceride concentrations. Liver superoxide dismutase activity positively correlated with glucose and cholesterol concentration. Vitamin E reduced plasma LPO, but did not affect the diabetic state. Thus, plasma LPO was the most reliable indicator of diabetes-induced oxidative stress. Antioxidant enzyme activities and types of reactive oxygen species generated were tissue dependent. Diabetes-induced oxidative stress is diminished by vitamin E supplementation.

AB - Determination of reliable bioindicators of diabetes-induced oxidative stress and the role of dietary vitamin E supplementation were investigated. Blood (plasma) chemistries, lipid peroxidation (LPO), and antioxidant enzyme activities were measured over 12 weeks in New Zealand White rabbits (control, diabetic, and diabetic + vitamin E). Cholesterol and triglyceride levels did not correlate with diabetic state. Plasma LPO was influenced by diabetes and positively correlated with glucose concentration only, not cholesterol or triglycerides. Liver glutathione peroxidase (GPX) activity negatively correlated with glucose and triglyceride levels. Plasma and erythrocyte GPX activities positively correlated with glucose, cholesterol, and triglyceride concentrations. Liver superoxide dismutase activity positively correlated with glucose and cholesterol concentration. Vitamin E reduced plasma LPO, but did not affect the diabetic state. Thus, plasma LPO was the most reliable indicator of diabetes-induced oxidative stress. Antioxidant enzyme activities and types of reactive oxygen species generated were tissue dependent. Diabetes-induced oxidative stress is diminished by vitamin E supplementation.

KW - Antioxidant

KW - Oxidative stress

KW - Type 1 diabetes

KW - Vitamin E

UR - http://www.scopus.com/inward/record.url?scp=0036662293&partnerID=8YFLogxK

U2 - 10.1080/15604280214279

DO - 10.1080/15604280214279

M3 - Article

C2 - 12458660

AN - SCOPUS:0036662293

VL - 3

SP - 185

EP - 192

JO - International Journal of Experimental Diabetes Research

JF - International Journal of Experimental Diabetes Research

SN - 1560-4284

IS - 3

ER -