Differential expression of vasopressin, oxytocin and corticotrophin-releasing hormone messenger RNA in the paraventricular nucleus of the prairie vole brain following stress

Y. Liu, J. T. Curtis, C. D. Fowler, C. Spencer, T. Houpt, Z. X. Wang

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Forced swimming, as an effective stressor, has been found to facilitate the development of pair bonds in male but to interfere with this behaviour in female prairie voles (Microtus ochrogaster). In the present study, we found that forced swimming differentially influenced the expression of messenger RNA for vasopressin, oxytocin and corticotrophin-releasing hormone (CRH) in the paraventricular nucleus of the hypothalamus (PVN) in the prairie vole brain. Forced swimming did not alter vasopressin mRNA labelling, but did induce a sustained decrease in oxytocin mRNA labelling and a progressive increase in CRH mRNA labelling in the PVN. The elevated CRH mRNA labelling appeared to be due to an increased number of cells synthesizing CRH mRNA and an enhanced ability of individual cells to produce CRH mRNA. Male and female prairie voles did not differ in the vasopressin, oxytocin or CRH mRNA expression either at the basal levels or in response to swimming stress. Together, these data indicate that the hypothalamic response of vasopressin, oxytocin and CRH messenger RNAs to swimming stress is regulated by distinct transcriptional factors. In addition, it seems unlikely that these changes are involved directly in the sex differences in pair bond formation.

Original languageEnglish
Pages (from-to)1059-1065
Number of pages7
JournalJournal of Neuroendocrinology
Volume13
Issue number12
DOIs
StatePublished - 11 Dec 2001

Fingerprint

Arvicolinae
Paraventricular Hypothalamic Nucleus
Corticotropin-Releasing Hormone
Oxytocin
Vasopressins
Messenger RNA
Brain
Pair Bond
Hypothalamus
Grassland
Aptitude
Sex Characteristics
Cell Count

Keywords

  • CRH
  • Monogamy
  • Oxytocin
  • PVN
  • Vasopressin

Cite this

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abstract = "Forced swimming, as an effective stressor, has been found to facilitate the development of pair bonds in male but to interfere with this behaviour in female prairie voles (Microtus ochrogaster). In the present study, we found that forced swimming differentially influenced the expression of messenger RNA for vasopressin, oxytocin and corticotrophin-releasing hormone (CRH) in the paraventricular nucleus of the hypothalamus (PVN) in the prairie vole brain. Forced swimming did not alter vasopressin mRNA labelling, but did induce a sustained decrease in oxytocin mRNA labelling and a progressive increase in CRH mRNA labelling in the PVN. The elevated CRH mRNA labelling appeared to be due to an increased number of cells synthesizing CRH mRNA and an enhanced ability of individual cells to produce CRH mRNA. Male and female prairie voles did not differ in the vasopressin, oxytocin or CRH mRNA expression either at the basal levels or in response to swimming stress. Together, these data indicate that the hypothalamic response of vasopressin, oxytocin and CRH messenger RNAs to swimming stress is regulated by distinct transcriptional factors. In addition, it seems unlikely that these changes are involved directly in the sex differences in pair bond formation.",
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Differential expression of vasopressin, oxytocin and corticotrophin-releasing hormone messenger RNA in the paraventricular nucleus of the prairie vole brain following stress. / Liu, Y.; Curtis, J. T.; Fowler, C. D.; Spencer, C.; Houpt, T.; Wang, Z. X.

In: Journal of Neuroendocrinology, Vol. 13, No. 12, 11.12.2001, p. 1059-1065.

Research output: Contribution to journalArticle

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