Differential diagnosis of depression and Alzheimer's disease using the cattell-horn-carroll theory

Anna Mazur-Mosiewicz, Beth A. Trammell, Chad A. Noggle, Raymond S. Dean

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Clinical differentiation between Alzheimer's disease (AD) and depression is often difficult due to symptom overlap and similar clinical presentation. Concise and accurate diagnostic tests have been of interest for many years. Furthermore, with the continued growth of the Cattell-Horn-Carroll (CHC) theory, there has been an emergence of measures such as the Woodcock-Johnson-III Tests of Cognitive Abilities (WJ-III COG), which are being more commonly used in clinical practice yet have not been fully evaluated in terms of their efficacy in various domains of clinical practice. This study investigated the predictive and diagnostic properties of the WJ-III COG as a CHC-based test in differentiating between AD and depression in the elderly population. A discriminative function used in the study was able to correctly classify 89.02% of cases using six areas of the CHC framework. The variables that had the highest predictive weights were: long-term retrieval, fluid reasoning, processing speed, and working memory. The main implication is that a theory-based approach is crucial in the support of differential diagnosis and in decreasing the length of assessment for elderly populations.

Original languageEnglish
Pages (from-to)252-262
Number of pages11
JournalApplied Neuropsychology
Volume18
Issue number4
DOIs
StatePublished - 1 Oct 2011

Fingerprint

Aptitude
Horns
Alzheimer Disease
Differential Diagnosis
Depression
Short-Term Memory
Routine Diagnostic Tests
Population
Weights and Measures
Growth
Alzheimer's Disease
Diagnostics
Clinical Practice
Cognitive Ability

Keywords

  • assessment/diagnosis
  • geriatric
  • tests

Cite this

Mazur-Mosiewicz, Anna ; Trammell, Beth A. ; Noggle, Chad A. ; Dean, Raymond S. / Differential diagnosis of depression and Alzheimer's disease using the cattell-horn-carroll theory. In: Applied Neuropsychology. 2011 ; Vol. 18, No. 4. pp. 252-262.
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Differential diagnosis of depression and Alzheimer's disease using the cattell-horn-carroll theory. / Mazur-Mosiewicz, Anna; Trammell, Beth A.; Noggle, Chad A.; Dean, Raymond S.

In: Applied Neuropsychology, Vol. 18, No. 4, 01.10.2011, p. 252-262.

Research output: Contribution to journalArticle

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