Different interaction between tricyclic antidepressants and mecamylamine with the human α3β4 nicotinic acetylcholine receptor ion channel

Keyphrases

• Nicotinic Acetylcholine Receptor (nAChR) 100%
• Ion Channels 100%
• Tricyclic Antidepressants 100%
• Mecamylamine 100%
• Imipramine 83%
• Acetylcholine Receptor (AChR) 66%
• IC50 50%
• Conformational States 50%
• Phenylalanine 33%
• Ca2+ Influx 33%
• Valine 33%
• Epibatidine 33%
• High Affinity 16%
• Radioligand Binding 16%
• Leucine 16%
• Physiological pH 16%
• Molecular Docking 16%
• α-bungarotoxin 16%
• Outer Ring 16%
• Ion Flux 16%
• Neutral State 16%
• Ki-1 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Nicotinic Receptor 100%
• Ion Channel 100%
• Tricyclic Antidepressant 100%
• Mecamylamine 100%
• Imipramine 83%
• IC50 50%
• Cholinergic Receptor 50%
• Calcium Ion 33%
• Valine 33%
• Phenylalanine 33%
• Epibatidine 33%
• Radioligand 16%
• Leucine 16%
• Bungarotoxin 16%
• Serine 16%

Biochemistry, Genetics and Molecular Biology

• Nicotinic Acetylcholine Receptor 100%
• Mecamylamine 100%
• Ion Channel 100%
• Acetylcholine Receptor 50%
• IC50 50%
• Epibatidine 33%
• Phenylalanine 33%
• Valine 33%
• Leucine 16%
• Docking (Molecular) 16%
• Radioligand 16%
• Ion Current 16%
• Bungarotoxin 16%
• Serine 16%