Dibenzazepines and dibenzoxazepines as sodium channel blockers

Stephen M. Lynch; Laykea Tafesse; Kevin Carlin; Parijat Ghatak; Donald J. Kyle

doi:10.1016/j.bmcl.2014.11.025

Dibenzazepines and dibenzoxazepines as sodium channel blockers

Stephen M. Lynch, Laykea Tafesse, Kevin Carlin, Parijat Ghatak, Donald J. Kyle

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

We have identified two related series of dibenzazepine and dibenzoxazepine sodium channel blockers, which showed good potency on Na_v1.7 in FLIPR-based and electrophysiological functional assays.

Original language	English
Pages (from-to)	43-47
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	25
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2014.11.025
State	Published - 1 Jan 2015
Externally published	Yes

Keywords

Dibenzazepine
Dibenzoxazepine
Na<inf>v</inf>1.7
Neuropathic pain
Sodium channel

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10.1016/j.bmcl.2014.11.025

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title = "Dibenzazepines and dibenzoxazepines as sodium channel blockers",

abstract = "We have identified two related series of dibenzazepine and dibenzoxazepine sodium channel blockers, which showed good potency on Nav1.7 in FLIPR-based and electrophysiological functional assays.",

keywords = "Dibenzazepine, Dibenzoxazepine, Na<inf>v</inf>1.7, Neuropathic pain, Sodium channel",

author = "Lynch, \{Stephen M.\} and Laykea Tafesse and Kevin Carlin and Parijat Ghatak and Kyle, \{Donald J.\}",

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AU - Lynch, Stephen M.

AU - Tafesse, Laykea

AU - Carlin, Kevin

AU - Ghatak, Parijat

AU - Kyle, Donald J.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - We have identified two related series of dibenzazepine and dibenzoxazepine sodium channel blockers, which showed good potency on Nav1.7 in FLIPR-based and electrophysiological functional assays.

AB - We have identified two related series of dibenzazepine and dibenzoxazepine sodium channel blockers, which showed good potency on Nav1.7 in FLIPR-based and electrophysiological functional assays.

KW - Dibenzazepine

KW - Dibenzoxazepine

KW - Na<inf>v</inf>1.7

KW - Neuropathic pain

KW - Sodium channel

UR - https://www.scopus.com/pages/publications/84913580295

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DO - 10.1016/j.bmcl.2014.11.025

M3 - Article

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AN - SCOPUS:84913580295

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EP - 47

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 1

ER -

Dibenzazepines and dibenzoxazepines as sodium channel blockers

Abstract

Keywords

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