Dibenzazepines and dibenzoxazepines as sodium channel blockers

Stephen M. Lynch; Laykea Tafesse; Kevin Carlin; Parijat Ghatak; Donald J. Kyle

doi:10.1016/j.bmcl.2014.11.025

Dibenzazepines and dibenzoxazepines as sodium channel blockers

Stephen M. Lynch
, Laykea Tafesse
, Kevin Carlin
, Parijat Ghatak
, Donald J. Kyle

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

We have identified two related series of dibenzazepine and dibenzoxazepine sodium channel blockers, which showed good potency on Na_v1.7 in FLIPR-based and electrophysiological functional assays.

Original language	English
Pages (from-to)	43-47
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	25
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2014.11.025
State	Published - 1 Jan 2015
Externally published	Yes

Keywords

Dibenzazepine
Dibenzoxazepine
Na<inf>v</inf>1.7
Neuropathic pain
Sodium channel

Access to Document

10.1016/j.bmcl.2014.11.025

Cite this

@article{1109540f898e467ea983f98459500d94,

title = "Dibenzazepines and dibenzoxazepines as sodium channel blockers",

abstract = "We have identified two related series of dibenzazepine and dibenzoxazepine sodium channel blockers, which showed good potency on Nav1.7 in FLIPR-based and electrophysiological functional assays.",

keywords = "Dibenzazepine, Dibenzoxazepine, Na<inf>v</inf>1.7, Neuropathic pain, Sodium channel",

author = "Lynch, \{Stephen M.\} and Laykea Tafesse and Kevin Carlin and Parijat Ghatak and Kyle, \{Donald J.\}",

year = "2015",

month = jan,

day = "1",

doi = "10.1016/j.bmcl.2014.11.025",

language = "English",

volume = "25",

pages = "43--47",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

number = "1",

}

TY - JOUR

T1 - Dibenzazepines and dibenzoxazepines as sodium channel blockers

AU - Lynch, Stephen M.

AU - Tafesse, Laykea

AU - Carlin, Kevin

AU - Ghatak, Parijat

AU - Kyle, Donald J.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - We have identified two related series of dibenzazepine and dibenzoxazepine sodium channel blockers, which showed good potency on Nav1.7 in FLIPR-based and electrophysiological functional assays.

AB - We have identified two related series of dibenzazepine and dibenzoxazepine sodium channel blockers, which showed good potency on Nav1.7 in FLIPR-based and electrophysiological functional assays.

KW - Dibenzazepine

KW - Dibenzoxazepine

KW - Na<inf>v</inf>1.7

KW - Neuropathic pain

KW - Sodium channel

UR - https://www.scopus.com/pages/publications/84913580295

U2 - 10.1016/j.bmcl.2014.11.025

DO - 10.1016/j.bmcl.2014.11.025

M3 - Article

C2 - 25466191

AN - SCOPUS:84913580295

SN - 0960-894X

VL - 25

SP - 43

EP - 47

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 1

ER -

Dibenzazepines and dibenzoxazepines as sodium channel blockers

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this